Intrathecal bivalent CAR T cells targeting EGFR and IL13Rα2 in recurrent glioblastoma: phase 1 trial interim results

Nature Medicine · 2024 · 314 citations

• Medicine
• Oncology
• Pharmacology

Search for Nearly Mass-Degenerate Higgsinos Using Low-Momentum Mildly Displaced Tracks in $pp$ Collisions at $\sqrt{s}$ = 13 TeV with the ATLAS Detector

arXiv (Cornell University) · 2024

• Physics
• Particle physics
• Nuclear physics

Higgsinos with masses near the electroweak scale can solve the hierarchy problem and provide a dark matter candidate, while detecting them at the LHC remains challenging if their mass splitting is $\mathcal{O}(1 \text{GeV})$. This Letter presents a novel search for nearly mass-degenerate Higgsinos in events with an energetic jet, missing transverse momentum, and a low-momentum track with a significant transverse impact parameter using 140 fb$^{-1}$ of proton-proton collision data at $\sqrt{s}=13$ TeV collected by the ATLAS experiment. For the first time since LEP, a range of mass splittings between the lightest charged and neutral Higgsinos from $0.3$ GeV to $0.9$ GeV is excluded at 95$\%$ confidence level, with a maximum reach of approximately $170$ GeV in the Higgsino mass.

Searches for additional Higgs bosons and for vector leptoquarks in ττ final states in proton-proton collisions at $$ \sqrt{s} $$ = 13 TeV

Journal of High Energy Physics · 2023 · 69 citations

• Physics
• Particle physics
• Nuclear physics

A bstract Three searches are presented for signatures of physics beyond the standard model (SM) in ττ final states in proton-proton collisions at the LHC, using a data sample collected with the CMS detector at $$ \sqrt{s} $$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:msqrt> <mml:mi>s</mml:mi> </mml:msqrt> </mml:math> = 13 TeV, corresponding to an integrated luminosity of 138 fb − 1 . Upper limits at 95% confidence level (CL) are set on the products of the branching fraction for the decay into τ leptons and the cross sections for the production of a new boson ϕ , in addition to the H(125) boson, via gluon fusion (gg ϕ ) or in association with b quarks, ranging from $$ \mathcal{O} $$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mi>O</mml:mi> </mml:math> (10 pb) for a mass of 60 GeV to 0.3 fb for a mass of 3.5 TeV each. The data reveal two excesses for gg ϕ production with local p -values equivalent to about three standard deviations at m ϕ = 0 . 1 and 1.2 TeV. In a search for t -channel exchange of a vector leptoquark U 1 , 95% CL upper limits are set on the dimensionless U 1 leptoquark coupling to quarks and τ leptons ranging from 1 for a mass of 1 TeV to 6 for a mass of 5 TeV, depending on the scenario. In the interpretations of the $$ {M}_{\textrm{h}}^{125} $$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:msubsup> <mml:mi>M</mml:mi> <mml:mi>h</mml:mi> <mml:mn>125</mml:mn> </mml:msubsup> </mml:math> and $$ {M}_{\textrm{h},\textrm{EFT}}^{125} $$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:msubsup> <mml:mi>M</mml:mi> <mml:mrow> <mml:mi>h</mml:mi> <mml:mo>,</mml:mo> <mml:mi>EFT</mml:mi> </mml:mrow> <mml:mn>125</mml:mn> </mml:msubsup> </mml:math> minimal supersymmetric SM benchmark scenarios, additional Higgs bosons with masses below 350 GeV are excluded at 95% CL.

High-field critical current density enhancement in GdBCO coated conductors by cooperative defects

Superconductor Science and Technology · 2023 · 12 citations

• Materials science
• Condensed matter physics
• Optoelectronics

Abstract Irradiation can precisely control defects in, and improve the superconducting properties of, REBa 2 Cu 3 O 7− δ (REBCO, RE: rare earth) coated conductors (CCs). Here we report an effective approach for enhancing the in-field performance of GdBCO CCs. The critical current density ( J c ) of GdBCO films was significantly improved through cooperative defects created by co-irradiation with O ions and protons, especially at low temperatures and high magnetic fields. Surprisingly, the in-field J c of commercial CCs can be nearly doubled. The cooperative irradiation-induced defects are uniformly distributed throughout the GdBCO layer, which promotes the overall performance of the CC. Moreover, the dimensions of these irradiation-induced defects closely match the coherence length of REBCO. This simple and efficient method is a practical post-production solution to improve the in-field performance of commercial REBCO CCs.

Measurement of the <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" altimg="si1.svg"><mml:msubsup><mml:mrow><mml:mtext>B</mml:mtext></mml:mrow><mml:mrow><mml:mtext>s</mml:mtext></mml:mrow><mml:mrow><mml:mn>0</mml:mn></mml:mrow></mml:msubsup><mml:mo stretchy="false">→</mml:mo><mml:msup><mml:mrow><mml:mi mathvariant="normal">μ</mml:mi></mml:mrow><mml:mrow><mml:mo linebreak="badbreak" linebreakstyle="after">+</mml:mo></mml:mrow></mml:msup><mml:msup><mml:mrow><mml:mi mathvariant="normal">μ</mml:mi></mml:mrow><mml:mrow><mml:mo linebreak="badbreak" linebreakstyle="after">−</mml:mo></mml:mrow></mml:msup></mml:math> decay properties and search for the B0 → μ+μ− decay in proton-proton collisions at <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" altimg="si2.svg"><mml:msqrt><mml:mrow><mml:mi>s</mml:mi></mml:mrow></mml:msqrt><mml:mo linebreak="goodbreak" linebreakstyle="after">=</mml:mo><mml:mn>13</mml:mn><mml:mspace width="0.2em"/><mml:mtext>TeV</mml:mtext></mml:math>

Physics Letters B · 2023 · 75 citations

• Computer Science
• Physics
• Algorithm

Measurements are presented of the Bs0→μ+μ− branching fraction and effective lifetime, as well as results of a search for the B0→μ+μ− decay in proton-proton collisions at s=13TeV at the LHC. The analysis is based on data collected with the CMS detector in 2016–2018 corresponding to an integrated luminosity of 140fb−1. The branching fraction of the Bs0→μ+μ− decay and the effective Bs0 meson lifetime are the most precise single measurements to date. No evidence for the B0→μ+μ− decay has been found. All results are found to be consistent with the standard model predictions and previous measurements.

Measurement of jet substructure in boosted $t\bar{t}$ events with the ATLAS detector using 140 fb$^{-1}$ of 13 TeV $pp$ collisions

arXiv (Cornell University) · 2023 · 1 citations

• Physics
• Particle physics
• Nuclear physics

Measurements of the substructure of top-quark jets are presented, using 140 fb$^{-1}$ of 13 TeV $pp$ collision data recorded with the ATLAS detector at the LHC. Top-quark jets reconstructed with the anti-$k_{t}$ algorithm with a radius parameter $R=1.0$ are selected in top-quark pair ($t\bar{t}$) events where one top quark decays semileptonically and the other hadronically, or where both top quarks decay hadronically. The top-quark jets are required to have transverse momentum $p_\mathrm{T} &gt; 350$ GeV, yielding large samples of data events with jet $p_\mathrm{T}$ values between 350 and 600 GeV. One- and two-dimensional differential cross-sections for eight substructure variables, defined using only the charged components of the jets, are measured in a particle-level phase space by correcting for the smearing and acceptance effects induced by the detector. The differential cross-sections are compared with the predictions of several Monte Carlo simulations in which top-quark pair-production quantum chromodynamic matrix-element calculations at next-to-leading-order precision in the strong coupling constant $\alpha_\mathrm{S}$ are passed to leading-order parton shower and hadronization generators. The Monte Carlo predictions for measures of the broadness, and also the two-body structure, of the top-quark jets are found to be in good agreement with the measurements, while variables sensitive to the three-body structure of the top-quark jets exhibit some tension with the measured distributions.

Technology Roadmap for Flexible Sensors

ACS Nano · 2023 · 1225 citations

• Computer Science
• Computer Science
• Systems engineering

Humans rely increasingly on sensors to address grand challenges and to improve quality of life in the era of digitalization and big data. For ubiquitous sensing, flexible sensors are developed to overcome the limitations of conventional rigid counterparts. Despite rapid advancement in bench-side research over the last decade, the market adoption of flexible sensors remains limited. To ease and to expedite their deployment, here, we identify bottlenecks hindering the maturation of flexible sensors and propose promising solutions. We first analyze challenges in achieving satisfactory sensing performance for real-world applications and then summarize issues in compatible sensor-biology interfaces, followed by brief discussions on powering and connecting sensor networks. Issues en route to commercialization and for sustainable growth of the sector are also analyzed, highlighting environmental concerns and emphasizing nontechnical issues such as business, regulatory, and ethical considerations. Additionally, we look at future intelligent flexible sensors. In proposing a comprehensive roadmap, we hope to steer research efforts towards common goals and to guide coordinated development strategies from disparate communities. Through such collaborative efforts, scientific breakthroughs can be made sooner and capitalized for the betterment of humanity.

Apoptotic cell death in disease—Current understanding of the NCCD 2023

Cell Death and Differentiation · 2023 · 344 citations

• Biology
• Cell biology
• Immunology

Elevated blood pressure accelerates white matter brain aging among late middle-aged women: a Mendelian Randomization study in the UK Biobank

Journal of Hypertension · 2023 · 13 citations

• Medicine
• Internal medicine
• Demography

BACKGROUND: Elevated blood pressure (BP) is a modifiable risk factor associated with cognitive impairment and cerebrovascular diseases. However, the causal effect of BP on white matter brain aging remains unclear. METHODS: In this study, we focused on N = 228 473 individuals of European ancestry who had genotype data and clinical BP measurements available (103 929 men and 124 544 women, mean age = 56.49, including 16 901 participants with neuroimaging data available) collected from UK Biobank (UKB). We first established a machine learning model to compute the outcome variable brain age gap (BAG) based on white matter microstructure integrity measured by fractional anisotropy derived from diffusion tensor imaging data. We then performed a two-sample Mendelian randomization analysis to estimate the causal effect of BP on white matter BAG in the whole population and subgroups stratified by sex and age brackets using two nonoverlapping data sets. RESULTS: The hypertension group is on average 0.31 years (95% CI = 0.13-0.49; P < 0.0001) older in white matter brain age than the nonhypertension group. Women are on average 0.81 years (95% CI = 0.68-0.95; P < 0.0001) younger in white matter brain age than men. The Mendelian randomization analyses showed an overall significant positive causal effect of DBP on white matter BAG (0.37 years/10 mmHg, 95% CI 0.034-0.71, P = 0.0311). In stratified analysis, the causal effect was found most prominent among women aged 50-59 and aged 60-69. CONCLUSION: High BP can accelerate white matter brain aging among late middle-aged women, providing insights on planning effective control of BP for women in this age group.

Analysis of the CP structure of the Yukawa coupling between the Higgs boson and τ leptons in proton-proton collisions at $$ \sqrt{s} $$ = 13 TeV

Journal of High Energy Physics · 2022 · 36 citations

• Physics
• Particle physics
• Nuclear physics

A bstract The first measurement of the CP structure of the Yukawa coupling between the Higgs boson and τ leptons is presented. The measurement is based on data collected in proton-proton collisions at $$ \sqrt{s} $$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:msqrt> <mml:mi>s</mml:mi> </mml:msqrt> </mml:math> = 13 TeV by the CMS detector at the LHC, corresponding to an integrated luminosity of 137 fb − 1 . The analysis uses the angular correlation between the decay planes of τ leptons produced in Higgs boson decays. The effective mixing angle between CP -even and CP -odd τ Yukawa couplings is found to be − 1 ± 19°, compared to an expected value of 0 ± 21° at the 68.3% confidence level. The data disfavour the pure CP -odd scenario at 3.0 standard deviations. The results are compatible with predictions for the standard model Higgs boson.