Alix E. Seif
· Associate Professor of Pediatrics (Oncology) at the Children's Hospital of PhiladelphiaUniversity of Pennsylvania · Rehabilitation Medicine
Active 2002–2026
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About
Alix E. Seif, MD, MPH, is an Associate Professor of Pediatrics (Oncology) at the Children's Hospital of Philadelphia. She is a core faculty member at CHOP and a member of the Penn Center for Cancer Care Innovation (PC3I). Dr. Seif serves as the Director of Clinical Research at the Center for Childhood Cancer Research within the Division of Oncology at The Children's Hospital of Philadelphia. Her educational background includes a BA in Linguistics with Honours from McGill University, an MA in Linguistics from McGill University, an MPH in Epidemiology and Biostatistics, and an MD from Oregon Health Sciences University. She is also certified in Implementation Science from the University of Pennsylvania. Her research and clinical work focus on pediatric oncology, with contributions to understanding leukemia, lymphoma, and other childhood cancers, as well as developing evidence-based approaches to personalized care in pediatric oncology.
Research topics
- Biology
- Immunology
- Medicine
- Computer Science
- Internal medicine
- Pathology
- Genetics
- Computational biology
- Virology
- Bioinformatics
Selected publications
Constrained chromatin accessibility in PU.1-mutated agammaglobulinemia patients
The Journal of Experimental Medicine · 2021 · 73 citations
The pioneer transcription factor (TF) PU.1 controls hematopoietic cell fate by decompacting stem cell heterochromatin and allowing nonpioneer TFs to enter otherwise inaccessible genomic sites. PU.1 deficiency fatally arrests lymphopoiesis and myelopoiesis in mice, but human congenital PU.1 disorders have not previously been described. We studied six unrelated agammaglobulinemic patients, each harboring a heterozygous mutation (four de novo, two unphased) of SPI1, the gene encoding PU.1. Affected…
Clinical Cancer Research · 2022 · 61 citations
PURPOSE: To study the biology and identify markers of severe cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS) in children after chimeric antigen receptor T-cell (CAR T) treatment. EXPERIMENTAL DESIGN: We used comprehensive proteomic profiling to measure over 1,400 serum proteins at multiple serial timepoints in a cohort of patients with B-cell acute lymphoblastic leukemia treated with the CD19-targeted CAR T CTL019 on two clinical trials. RESULTS…
Microbiology Spectrum · 2025-06-24 · 4 citations
articleOpen accessfamily. The BKPyV genome is divided into three regions, including the non-coding control region (NCCR), the early region, and the late region. BKPyV has one of the highest mutation rates among DNA viruses, and four genotypes have been identified based on amino acid variation within the VP1 region. Mutations within the NCCR have been noted, and this region exhibits hypervariability. Here, we show that many of the point mutations observed within the NCCR are genotype-associated, termed genotype-as…
Nature Communications · 2025-10-22 · 1 citations
articleOpen accessAbstract B-cell acute lymphoblastic leukemia (B-ALL) is the most common pediatric malignancy. Given racial/ethnic differences in incidence and outcomes, B-ALL genome-wide association studies among children of African ancestry are needed. Leveraging multi-institutional datasets with 840 African American children with B-ALL and 3360 controls, nine loci achieved genome-wide significance ( P < 5 × 10 −8 ) after meta-analysis. Two loci were established trans-ancestral susceptibility regions ( IKZF…
Concurrent Juvenile Myelomonocytic Leukemia and Gliomas in Patients With Neurofibromatosis Type 1
Pediatric Blood & Cancer · 2025-12-27 · 1 citations
articleOpen accessNeurofibromatosis 1 (NF1) is the most common cancer predisposition syndrome and is characterized by a wide range of clinical manifestations, including increased risk of developing various types of malignancies. We report nine patients with NF1 who presented with concurrent diagnoses of juvenile myelomonocytic leukemia and low-grade glioma, a rare combination. One notable feature of this cohort is that eight patients (89%) harbored nonsense germline NF1 variants. This case series highlights the e…
Frequent coauthors
- 301 shared
Richard Aplenc
Hospital for Sick Children
- 248 shared
Brian T. Fisher
University of Pennsylvania
- 205 shared
Yimei Li
Children's Hospital of Philadelphia
- 176 shared
Stephan A. Grupp
Children's Hospital of Philadelphia
- 109 shared
Yuan‐Shung Huang
Children's Hospital of Philadelphia
- 105 shared
David T. Teachey
Children's Hospital of Philadelphia
- 96 shared
Rochelle Bagatell
Children's Hospital of Philadelphia
- 93 shared
Kelly Getz
University of Pennsylvania
Education
- 1992
B.A., Linguistics - Honours, First Class
McGill University
- 1995
M.A., Linguistics
McGill University
- 2002
M.D.
Oregon Health Sciences University
- 2002
Other, Epidemiology and Biostatistics
Oregon Health Sciences University
- 2025
Other, Implementation Science
University of Pennsylvania
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