About

Juhee Lee, MD, is an Assistant Professor of Clinical Pediatrics specializing in Allergy and Immunology at the Children’s Hospital of Philadelphia. She serves as an Attending Physician in the Division of Allergy & Immunology and is also the Quality and Patient Safety Officer within the same division. Additionally, she holds the position of Associate Program Director for the Allergy & Immunology Fellowship Program. Dr. Lee's educational background includes a BA in Psychology from Brown University and an MD from Tufts University School of Medicine. Her professional work focuses on clinical care, education, and research in allergy and immunology, with a particular emphasis on immunodeficiency syndromes such as chromosome 22q11.2 duplication syndrome and allergic reactions. She has contributed to the understanding of immunologic, molecular, and clinical profiles of patients with genetic duplications, as well as improving management strategies for allergic conditions in pediatric populations.

Research topics

• Virology
• Pathology
• Immunology
• Biology
• Genetics
• Medicine

Selected publications

• Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease

  Nature Immunology · 2024 · 89 citations

  • Medicine
  • Immunology
  • Virology

  . Here we profiled 368 plasma proteins in 657 participants ≥3 months following hospitalization. Of these, 426 had at least one long COVID symptom and 233 had fully recovered. Elevated markers of myeloid inflammation and complement activation were associated with long COVID. IL-1R2, MATN2 and COLEC12 were associated with cardiorespiratory symptoms, fatigue and anxiety/depression; MATN2, CSF3 and C1QA were elevated in gastrointestinal symptoms and C1QA was elevated in cognitive impairment. Additional markers of alterations in nerve tissue repair (SPON-1 and NFASC) were elevated in those with cognitive impairment and SCG3, suggestive of brain-gut axis disturbance, was elevated in gastrointestinal symptoms. Severe acute respiratory syndrome coronavirus 2-specific immunoglobulin G (IgG) was persistently elevated in some individuals with long COVID, but virus was not detected in sputum. Analysis of inflammatory markers in nasal fluids showed no association with symptoms. Our study aimed to understand inflammatory processes that underlie long COVID and was not designed for biomarker discovery. Our findings suggest that specific inflammatory pathways related to tissue damage are implicated in subtypes of long COVID, which might be targeted in future therapeutic trials.

  DOI

Recent grants

• 02 Research Animal Support Facility-Houston/Smithville

  NIH · $92.3M · 1996–2026

Frequent coauthors

• Hyung‐Ho Kim

  62 shared

• Do Joong Park

  Seoul National University Hospital

  61 shared

• Chang Gi Park

  University of Illinois Urbana-Champaign

  47 shared

• Soomin Hong

  46 shared

• Jong Hee Chang

  Yonsei University

  39 shared

• Jiyeon Lee

  Yonsei University

  38 shared

• Tae Hee Kim

  Komipharm International (South Korea)

  36 shared

• Mona Choi

  Yonsei University Health System

  21 shared

Education

• Adult/Gerontology Primary Care Nurse Practitioner(AGPCNP), College of Nursing

  University of Massachusetts Boston

  2011

• Ph.D, Nursing

  University of Maryland Baltimore

  2005

• MSN, Nursing

  Yonsei University

  2000

• BSN, Nursing

  Yonsei University

  1995

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