Yasmin Bradfield

About

Yasmin Bradfield, MD, is the John W. Doolittle Pediatric Ophthalmology Professor at the University of Wisconsin–Madison, where she also serves as the Pediatric Ophthalmology and Strabismus Fellowship Director since 2022. Her clinical and research interests include pediatric ophthalmology and adult strabismus, with specific focus on amblyopia, congenital tear duct obstruction, pediatric and adult strabismus, pediatric cataract and intraocular lenses, pediatric eyelid surgery, and pediatric glaucoma. Dr. Bradfield's research emphasizes pediatric glaucoma genetics, vision outcomes, and factors associated with visual development, as well as clinical trials such as PEDIG's binocular amblyopia treatment versus standard care and anterior segment OCT imaging in pediatric glaucoma. Her notable contributions include a comprehensive multicenter study with the Pediatric Eye Disease Investigator Group that established normative central corneal thickness in healthy children, revealing age and racial differences with implications for glaucoma risk assessment. She has also mentored research projects, including a study demonstrating that Schlemm’s canal can be visualized three-dimensionally by OCT in infants with and without glaucoma, which can be integrated into clinical care algorithms. Dr. Bradfield's educational background includes a fellowship in Pediatric Ophthalmology and Strabismus at Riley Children's Hospital, residency at Mayo Clinic, internship at St. Joseph Hospital in Chicago,…

Research topics

• Medicine
• Ophthalmology
• Surgery
• Internal medicine
• Genetics
• Optometry
• Pathology
• Biology
• Anesthesia

Selected publications

• Angiopoietin-1 is required for Schlemm’s canal development in mice and humans

  Journal of Clinical Investigation · 2017-11-05 · 198 citations

  articleOpen access

  Primary congenital glaucoma (PCG) is a leading cause of blindness in children worldwide and is caused by developmental defects in 2 aqueous humor outflow structures, Schlemm's canal (SC) and the trabecular meshwork. We previously identified loss-of-function mutations in the angiopoietin (ANGPT) receptor TEK in families with PCG and showed that ANGPT/TEK signaling is essential for SC development. Here, we describe roles for the major ANGPT ligands in the development of the aqueous outflow pathway…

  PublisherOA PDFDOI

• <i>SVEP1</i> as a Genetic Modifier of <i>TEK</i>-Related Primary Congenital Glaucoma

  Investigative Ophthalmology & Visual Science · 2020 · 56 citations

  Purpose: Affecting children by age 3, primary congenital glaucoma (PCG) can cause debilitating vision loss by the developmental impairment of aqueous drainage resulting in high intraocular pressure (IOP), globe enlargement, and optic neuropathy. TEK haploinsufficiency accounts for 5% of PCG in diverse populations, with low penetrance explained by variable dysgenesis of Schlemm's canal (SC) in mice. We report eight families with TEK-related PCG, and provide evidence for SVEP1 as a disease modifie…

  PublisherOA PDFDOI

• Visual Acuity and Ophthalmic Outcomes 5 Years After Cataract Surgery Among Children Younger Than 13 Years

  JAMA Ophthalmology · 2022 · 32 citations

  IMPORTANCE: Cataract is an important cause of visual impairment in children. Data from a large pediatric cataract surgery registry can provide real-world estimates of visual outcomes and the 5-year cumulative incidence of adverse events. OBJECTIVE: To assess visual acuity (VA), incidence of complications and additional eye operations, and refractive error outcomes 5 years after pediatric lensectomy among children younger than 13 years. DESIGN, SETTING, AND PARTICIPANTS: This prospective cohort s…

  PublisherOA PDFDOI

• Validation of Peek Acuity application in pediatric screening programs in Paraguay

  International Journal of Ophthalmology · 2018-08-08 · 26 citations

  articleOpen access

  AIM: To validate the Peek Acuity mobile phone application in pediatric populations and compare its utility, both economic and diagnostic, against conventional screening methods using a pediatric ophthalmologist examination as the gold standard. METHODS: A cohort of 393 subjects from Fernando de la Mora, Paraguay (ages 6-16y) were enrolled in the study. Subjects were randomly assigned a starting screening modality among: Peek Acuity, a single line of tumbling E optotypes set at 20/40, and Spot Vi…

  PublisherOA PDFDOI

• Comparative Intraoperative Anterior Segment OCT Findings in Pediatric Patients with and without Glaucoma

  Ophthalmology Glaucoma · 2019-05-08 · 21 citations

  article1st authorCorresponding
  PublisherDOI

Frequent coauthors

• Michael Struck

  76 shared

• Eileen E. Birch

  Retina Foundation of the Southwest

  71 shared

• Ronald E. Gangnon

  70 shared

• Thomas D. France

  67 shared

• Evelyn A. Paysse

  66 shared

• David K. Coats

  66 shared

• David M. Gamm

  University of Wisconsin–Madison

  65 shared

• Natalie Boyle

  NHS Ayrshire and Arran

  64 shared

Education

• M.D., Ophthalmology

  University of Wisconsin–Madison

  2000

• B.S., Biology

  University of Wisconsin–Madison

  1996

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