Yan Gong

About

Yan Gong, Ph.D., is an Associate Professor in the Department of Pharmacotherapy and Translational Research at the University of Florida (UF) College of Pharmacy and the UF Center for Pharmacogenomics and Precision Medicine. She received her Ph.D. in Pharmaceutics in 2004 from the UF College of Pharmacy and a Master’s Degree in Statistics in 2003 from the UF Department of Statistics. Prior to joining the UF faculty in 2005, she completed a one-year post-doctoral Fellowship in Cardiovascular Pharmacogenomics at the UF Center for Pharmacogenomics. Dr. Gong's research focuses on the pharmacogenomics of efficacy and adverse responses of antihypertensive medications, as well as serious adverse drug events such as medication-related osteonecrosis of the jaw (MRONJ) and cardiotoxicities related to cancer therapies (Cardio-Oncology). She has authored over 170 peer-reviewed publications. In addition to her research activities, Dr. Gong is involved in teaching multiple graduate and professional courses at UF College of Pharmacy and College of Medicine. She is currently the course co-coordinator for Pharmacogenomic and Genomic Data Analysis (PHA6449), a required graduate course for her department.

Research topics

• Medicine
• Internal medicine
• Cardiology
• Biology
• Genetics
• Immunology
• Cancer research
• Bioinformatics
• Biochemistry

Selected publications

• Genetically determined NLRP3 inflammasome activation associates with systemic inflammation and cardiovascular mortality

  European Heart Journal · 2021 · 91 citations

  AIMS: Inflammation plays an important role in cardiovascular disease (CVD) development. The NOD-like receptor protein-3 (NLRP3) inflammasome contributes to the development of atherosclerosis in animal models. Components of the NLRP3 inflammasome pathway such as interleukin-1β can therapeutically be targeted. Associations of genetically determined inflammasome-mediated systemic inflammation with CVD and mortality in humans are unknown. METHODS AND RESULTS: We explored the association of genetic N…

  DOI

• Cost-effectiveness of CYP2C19-guided antiplatelet therapy in patients with acute coronary syndrome and percutaneous coronary intervention informed by real-world data

  The Pharmacogenomics Journal · 2020 · 44 citations

  DOI

• Association of 1-Year Blood Pressure Variability With Long-term Mortality Among Adults With Coronary Artery Disease

  JAMA Network Open · 2021 · 42 citations

  Importance: Accumulating evidence indicates that higher blood pressure (BP) variability from one physician office visit to the next (hereafter referred to as visit-to-visit BP variability) is associated with poor outcomes. Short-term measurement (throughout 1 year) of visit-to-visit BP variability in high-risk older patients may help identify patients at increased risk of death. Objective: To evaluate whether short-term visit-to-visit BP variability is associated with increased long-term mortali…

  DOI

• SIRT1 Gene SNP rs932658 Is Associated With Medication-Related Osteonecrosis of the Jaw

  Journal of Bone and Mineral Research · 2020 · 24 citations

  Senior authorCorresponding

  > 0.8) with rs7896005. To validate the association between these SNPs and MRONJ, we genotyped these three SNPs on the germline DNA from 104 cancer patients of European ancestry treated with iv BPs (46 cases and 58 controls). Multivariable logistic regression analysis showed the minor alleles of these three SNPs were associated with lower odds for MRONJ. The odds ratios (95% confidence interval) and p values were 0.351 (0.164-0.751; p = 0.007) for rs3758391, 0.351 (0.164-0.751; p = 0.007) for rs9…

  DOI

• Effectiveness of Clopidogrel vs Alternative P2Y12 Inhibitors Based on the ABCD-GENE Score

  Journal of the American College of Cardiology · 2024 · 23 citations

  PublisherOA PDFDOI

Frequent coauthors

• Julie A. Johnson

  University of North Carolina at Chapel Hill

  745 shared

• Rhonda M. Cooper‐DeHoff

  University of Florida

  708 shared

• Amber L. Beitelshees

  University of Maryland, Baltimore

  530 shared

• John G. Gums

  University of Florida

  504 shared

• Eric Boerwinkle

  The University of Texas Health Science Center at Houston

  496 shared

• Stephen T. Turner

  Australian Regenerative Medicine Institute

  475 shared

• Caitrin W. McDonough

  University of Florida

  316 shared

• Carl J. Pepine

  University of Florida

  310 shared

Education

• Ph.D., Pharmaceutics

  University of Florida

  2004

• M.S., Statistics

  University of Florida

  2003

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• Joseph Collinsh-61
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