Jeff Johnson
· Professor, AnthropologyUniversity of Florida · Toxicology and Pharmacology
Active 1973–2026
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About
Jeffrey C. Johnson, Ph.D., is a Professor of Anthropology at the University of Florida. He earned his B.A. in Anthropology from the University of California, Irvine in 1975 and his Ph.D. in Social Science from the same institution in 1981. Johnson has been active in research projects funded by Sea Grant and the National Oceanic and Atmospheric Administration for over thirty years. His extensive long-term research includes comparative studies of group dynamics of over-wintering crews at the American South Pole Station and other Antarctic stations operated by Poland, Russia, China, and India. He is interested in network models of complex biological systems and has worked on applying continuous time Markov chain and exponential random graph models to the study of trophic dynamics in food webs. His recent work, funded by the Office of Naval Research, involves developing methods for reliable tagging, coding, and network modeling of large corpora of related texts. Johnson has published extensively across multiple scientific disciplines, including anthropology, sociology, biology, and marine science. He was the founding editor of the Journal of Quantitative Anthropology and co-editor of Human Organization. Currently, he serves as an associate editor for the Journal of Social Structure and Social Networks. Johnson is also the Director of the Summer Institute for Research Design in Cultural Anthropology, funded by the National Science Foundation, and is the author of 'Selecting…
Research topics
- Medicine
- Internal medicine
- Computer Science
- Cardiology
- Genetics
- Medical physics
- Pharmacology
- Environmental health
- Political Science
- Biology
Selected publications
Clinical Pharmacology & Therapeutics · 2020 · 290 citations
Proton pump inhibitors (PPIs) are widely used for acid suppression in the treatment and prevention of many conditions, including gastroesophageal reflux disease, gastric and duodenal ulcers, erosive esophagitis, Helicobacter pylori infection, and pathological hypersecretory conditions. Most PPIs are metabolized primarily by cytochrome P450 2C19 (CYP2C19) into inactive metabolites, and CYP2C19 genotype has been linked to PPI exposure, efficacy, and adverse effects. We summarize the evidence from…
European Heart Journal · 2021 · 91 citations
AIMS: Inflammation plays an important role in cardiovascular disease (CVD) development. The NOD-like receptor protein-3 (NLRP3) inflammasome contributes to the development of atherosclerosis in animal models. Components of the NLRP3 inflammasome pathway such as interleukin-1β can therapeutically be targeted. Associations of genetically determined inflammasome-mediated systemic inflammation with CVD and mortality in humans are unknown. METHODS AND RESULTS: We explored the association of genetic N…
How to Integrate CYP2D6 Phenoconversion Into Clinical Pharmacogenetics: A Tutorial
Clinical Pharmacology & Therapeutics · 2021 · 86 citations
CYP2D6 genotype is increasingly being integrated into practice to guide prescribing of certain medications. The CYP2D6 drug metabolizing enzyme is susceptible to inhibition by concomitant drugs, which can lead to a clinical phenotype that is different from the genotype-based phenotype, a process referred to as phenoconversion. Phenoconversion is highly prevalent but not widely integrated into practice because of either limited experience on how to integrate or lack of knowledge that it has occur…
Genetics in Medicine · 2021 · 69 citations
Design and Early Implementation Successes and Challenges of a Pharmacogenetics Consult Clinic
Journal of Clinical Medicine · 2020 · 45 citations
testing, provided evidence-based pharmacogenetic recommendations to PCPs, and educated PCPs and patients on the results. Operational and clinical metrics were analyzed. In two years, 91 referred patients were seen in clinic (mean age 57, 67% women, 91% European-American). Of patients who received PGT, 77% had at least one CYP2C19 and/or CYP2D6 phenotype that would make conventional prescribing unfavorable. Recommendations suggested that physicians change a medication/dose for 59% of patients; ex…
Recent grants
Training Program for Applied Research and Development in Genomic Medicine
NIH · $3.2M · 2018–2028
NIH · $30.1M · 2011
NIH · $2.0M · 2016
Frequent coauthors
- 1437 shared
Braxton D. Mitchell
- 1425 shared
Alan R. Shuldiner
Regeneron (United States)
- 1363 shared
Vincent Thijs
University of Melbourne
- 1352 shared
Daniel Woo
University of Cincinnati
- 1340 shared
Hakan Ay
Biomedical Research Institute
- 1340 shared
Pankaj Sharma
ARC Centre of Excellence in Future Low-Energy Electronics Technologies
- 1340 shared
Hugh S. Markus
University of Cambridge
- 1333 shared
Martin Dichgans
German Center for Neurodegenerative Diseases
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