Joseph Collins

About

Joseph Collins, Ph.D., is a Research Assistant Professor in the Department of Pharmacotherapy and Translational Research at the University of Florida College of Pharmacy. He received his Ph.D. in Plant Molecular and Cellular Biology in 2018 from the University of Florida. Before becoming UF faculty in the fall of 2023, Dr. Collins worked as a post-doctoral researcher investigating the underlying cause of variable expression of the pharmacogenes in the UF department of pharmacotherapy and translational research. His research interests are related to the regulation of gene expression and how genetic and epigenetic variation contributes to differential gene expression. He uses bioinformatics and functional genomics to identify putative targets and then validates them through an array of molecular biology approaches. His current research focuses on the identification of enhancers that control key pharmacogenes and the identification of novel variants to explain observed differences in gene expression between populations.

Research topics

• Chemistry
• Biology
• Endocrinology
• Medicine
• Biochemistry
• Physiology
• Internal medicine
• Pharmacology
• Pathology
• Cell biology

Selected publications

• The biology of mammalian multi-copper ferroxidases

  BioMetals · 2022 · 63 citations

  DOI

• Copper nutrition and biochemistry and human (patho)physiology

  Advances in food and nutrition research · 2021 · 48 citations

  1st authorCorresponding
  DOI

• Iron homeostasis in older adults: balancing nutritional requirements and health risks

  The journal of nutrition health & aging · 2024-03-14 · 47 citations

  articleOpen access

  Iron plays a crucial role in many physiological processes, including oxygen transport, bioenergetics, and immune function. Iron is assimilated from food and also recycled from senescent red blood cells. Iron exists in two dietary forms: heme (animal based) and non-heme (mostly plant based). The body uses iron for metabolic purposes, and stores the excess mainly in splenic and hepatic macrophages. Physiologically, iron excretion in humans is inefficient and not highly regulated, so regulation of…

  PublisherDOI

• Oral iron therapy: Current concepts and future prospects for improving efficacy and outcomes

  British Journal of Haematology · 2024-01-22 · 41 citations

  reviewOpen accessSenior author

  Summary Iron deficiency (ID) and iron‐deficiency anaemia (IDA) are global public health concerns, most commonly afflicting children, pregnant women and women of childbearing age. Pathological outcomes of ID include delayed cognitive development in children, adverse pregnancy outcomes and decreased work capacity in adults. IDA is usually treated by oral iron supplementation, typically using iron salts (e.g. FeSO 4 ); however, dosing at several‐fold above the RDA may be required due to less effici…

  PublisherOA PDFDOI

• Oral Administration of Ginger-Derived Lipid Nanoparticles and Dmt1 siRNA Potentiates the Effect of Dietary Iron Restriction and Mitigates Pre-Existing Iron Overload in Hamp KO Mice

  Nutrients · 2021 · 34 citations

  Senior authorCorresponding

  ) absorption (~20% lower), pancreatic non-heme iron (reduced by ~65%), and serum ferritin (decreased 40-50%). Ginger may thus contain bioactive lipids that also influence iron homeostasis. In conclusion, the combinatorial approach of FA-GDLV and Dmt1 siRNA treatment, with dietary iron restriction, mitigated pre-existing iron overload in a murine model of HH.

  DOI

Recent grants

• Molecular Mechanisms of Intestinal Metal Ion Transport During Iron Deficiency

  NIH · $4.8M · 2007–2024

• NIH Grant R21DK068349

  NIH · $377k · 2007

• Molecular Mechanisms of Intestinal Metal Ion Transport During Iron Deficiency

  NIH · $326k · 2007–2017

Frequent coauthors

• Fayez K. Ghishan

  University of Arizona

  64 shared

• Albert J. Augustin

  Städtisches Klinikum Karlsruhe

  60 shared

• Hua Xu

  Shanghai Mental Health Center

  30 shared

• Ronald D. Fine

  Prince of Wales Hospital

  25 shared

• W. G. Johanson

  24 shared

• Pawel R. Kiela

  University of Arizona

  24 shared

• Jung‐Heun Ha

  University of Chicago

  24 shared

• Shireen RL Flores

  University of Florida

  21 shared

Education

• PhD, Molecular Physiology and Biophysics

  Vanderbilt University

  1995

• MS, Biology

  Middle Tennessee State University

  1991

• BS, Biology

  Sewanee The University of the South

  1987

Similar researchers at University of Florida

• Charles Peloquinh-84
• Yan Gongh-65
• Jatinder Lambah-60