Vadim Fedorov

About

Vadim Fedorov, PhD, is a Professor of Physiology and Cell Biology at The Ohio State University College of Medicine. His main research focus is on the mechanisms and treatments of human sinoatrial node function and atrial fibrillation, with the goal of developing new therapies for malignant cardiac arrhythmias. In his lab, he has developed an integrated approach to study heart rate disorders directly in humans using functional, molecular, and structural 3D mapping techniques, including a dual-sided high-resolution optical mapping system capable of resolving intramural activation in complex 3D atrial structures. His contributions include demonstrating that in human hearts, fatty tissue and fibrosis insulate the sinoatrial node while electrical communication is restricted to specific conduction pathways. He has shown that pathological upregulation of fibrosis and adenosine A1 receptors within the SAN may lead to tachycardia-bradycardia arrhythmias and cardiac arrest, and is developing therapies based on this data. Additionally, his research on atrial fibrillation has defined the sources of AF and their underlying mechanisms, revealing that AF is driven by intramural reentry anchored to microanatomic tracks in diseased human atria. Collaborating with clinical surgeons and electrophysiologists, he is working on highly selective, patient-specific treatments for AF.

Research topics

• Cardiology
• Medicine
• Internal medicine
• Chemistry

Selected publications

• Impaired neuronal sodium channels cause intranodal conduction failure and reentrant arrhythmias in human sinoatrial node

  Nature Communications · 2020 · 52 citations

  Senior authorCorresponding

  is essential for SAN conduction, especially in fibrotic failing hearts. Our results reveal that not only cNav but nNav are also integral for preventing disease-induced failure in human SAN intranodal conduction. Disease-impaired nNav may underlie patient-specific SAN dysfunctions and should be considered to treat arrhythmias.

  DOI

• Pharmacologic Approach to Sinoatrial Node Dysfunction

  The Annual Review of Pharmacology and Toxicology · 2020 · 47 citations

  The spontaneous activity of the sinoatrial node initiates the heartbeat. Sino-atrial node dysfunction (SND) and sick sinoatrial (sick sinus) syndrome are caused by the heart's inability to generate a normal sinoatrial node action potential. In clinical practice, SND is generally considered an age-related pathology, secondary to degenerative fibrosis of the heart pacemaker tissue. However, other forms of SND exist, including idiopathic primary SND, which is genetic, and forms that are secondary t…

  DOI

• Atrial fibrillation nomenclature, definitions, and mechanisms: Position paper from the international Working Group of the Signal Summit

  Heart Rhythm · 2024-11-17 · 15 citations

  reviewOpen access

  The international Working Group of the Signal Summit is a consortium of experts in the field of cardiac electrophysiology dedicated to advancing knowledge on understanding and clinical application of signal recording and processing techniques. In 2023, the working group met in Reykjavik, Iceland, and laid the foundation for this manuscript. Atrial fibrillation (AF) is the most common arrhythmia in adults, with a rapidly increasing prevalence worldwide. Despite substantial research efforts, advan…

  PublisherOA PDFDOI

• Chamber-specific wall thickness features in human atrial fibrillation

  Interface Focus · 2023-12-15 · 12 citations

  articleOpen accessSenior authorCorresponding

  Persistent atrial fibrillation (AF) is not effectively treated due to a lack of adequate tools for identifying patient-specific AF substrates. Recent studies revealed that in 30–50% of patients, persistent AF is maintained by localized drivers not only in the left atrium (LA) but also in the right atrium (RA). The chamber-specific atrial wall thickness (AWT) features underlying AF remain elusive, though the important role of AWT in AF is widely acknowledged. We aimed to provide direct evidence o…

  PublisherDOI

• Mechanistic insight into the functional role of human sinoatrial node conduction pathways and pacemaker compartments heterogeneity: A computer model analysis

  PLoS Computational Biology · 2023-12-18 · 8 citations

  articleOpen accessSenior authorCorresponding

  The sinoatrial node (SAN), the primary pacemaker of the heart, is responsible for the initiation and robust regulation of sinus rhythm. 3D mapping studies of the ex-vivo human heart suggested that the robust regulation of sinus rhythm relies on specialized fibrotically-insulated pacemaker compartments (head, center and tail) with heterogeneous expressions of key ion channels and receptors. They also revealed up to five sinoatrial conduction pathways (SACPs), which electrically connect the SAN wi…

  PublisherDOI

Recent grants

• Integration of structure and signaling in cardiac pacemaker function

  NIH · $4.2M · 2013–2024

• Targeting the Arrhythmogenic Sources of Human Atrial Fibrillation

  NIH · $5.3M · 2017–2027

Frequent coauthors

• Igor R. Efimov

  130 shared

• Peter J. Mohler

  The Ohio State University

  114 shared

• Brian J. Hansen

  The Ohio State University Wexner Medical Center

  94 shared

• Paul M.L. Janssen

  The Ohio State University

  79 shared

• Halina Dobrzynski

  Jagiellonian University

  76 shared

• Ning Li

  Westlake University

  72 shared

• Thomas A. Csepe

  65 shared

• Jichao Zhao

  University of Auckland

  60 shared

Education

• PhD, Physiology, Cardiac Electrophysiology

  Russian Cardiology Research and Production Complex

  1999

• MS, Applied Physics and Biomedical Engineering, Physics of Living System

  Moscow Institute of Physics and Technology

  1996

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