Sandor Gyorke

About

Sandor Gyorke, PhD, is a Professor of Physiology and Cell Biology at The Ohio State University College of Medicine. His research group focuses on the study of processes that regulate the contraction of the heart under both normal conditions and during cardiac disease. His work is concerned with the mechanisms that govern the gating activity of the cardiac ryanodine receptor (RyR2) channels and control the release of calcium from the sarcoplasmic reticulum. Additionally, his research is devoted to understanding alterations of intracellular calcium handling in disease conditions, particularly those related to cardiac rhythm disorders (arrhythmia) and pump function (heart failure), which are leading causes of morbidity and mortality worldwide. His goal is to gain fundamental insights into these mechanisms to develop novel treatments.

Research topics

• Chemistry
• Cell biology
• Internal medicine
• Biology
• Medicine
• Biochemistry
• Cardiology
• Endocrinology
• Biophysics
• Immunology

Selected publications

• Increased RyR2 activity is exacerbated by calcium leak-induced mitochondrial ROS

  Basic Research in Cardiology · 2020 · 118 citations

  handling, promoting mito-ROS emission and driving further channel activity in a proarrhythmic feedback cycle in the diseased heart.

  DOI

• Vascular endothelial growth factor promotes atrial arrhythmias by inducing acute intercalated disk remodeling

  Scientific Reports · 2020 · 52 citations

  1.5-rich ID nanodomains and slowing atrial conduction. These data highlight inflammation-induced vascular leak as a potential factor in the development and progression of AF.

  DOI

• Impaired neuronal sodium channels cause intranodal conduction failure and reentrant arrhythmias in human sinoatrial node

  Nature Communications · 2020 · 52 citations

  is essential for SAN conduction, especially in fibrotic failing hearts. Our results reveal that not only cNav but nNav are also integral for preventing disease-induced failure in human SAN intranodal conduction. Disease-impaired nNav may underlie patient-specific SAN dysfunctions and should be considered to treat arrhythmias.

  DOI

• Distributed synthesis of sarcolemmal and sarcoplasmic reticulum membrane proteins in cardiac myocytes

  Basic Research in Cardiology · 2021 · 32 citations

  Senior authorCorresponding

  It is widely assumed that synthesis of membrane proteins, particularly in the heart, follows the classical secretory pathway with mRNA translation occurring in perinuclear regions followed by protein trafficking to sites of deployment. However, this view is based on studies conducted in less-specialized cells, and has not been experimentally addressed in cardiac myocytes. Therefore, we undertook direct experimental investigation of protein synthesis in cardiac tissue and isolated myocytes using…

  DOI

• Sexual dimorphism in bidirectional SR-mitochondria crosstalk in ventricular cardiomyocytes

  Basic Research in Cardiology · 2023 · 20 citations

  handling and ETC organization may contribute to cardioprotection in healthy premenopausal females.

  PublisherOA PDFDOI

Recent grants

• NIH Grant R03TW005543

  NIH · $235k · 2008

• NIH Grant K02HL003739

  NIH · $353k · 2002

• Controlled and Uncontrollable Calcium release in heart

  NIH · $8.1M · 1999–2024

Frequent coauthors

• Dmitry Terentyev

  The Ohio State University

  267 shared

• Radmila Terentyeva

  The Ohio State University

  187 shared

• Serge Viatchenko‐Karpinski

  Cyprotex (United States)

  171 shared

• Inna Györke

  The Ohio State University

  157 shared

• Andriy E. Belevych

  The Ohio State University

  147 shared

• Pompeo Volpe

  University of Padua

  131 shared

• Silvia G. Priori

  University of Pavia

  117 shared

• Simon C. Williams

  Wellcome / EPSRC Centre for Interventional and Surgical Sciences

  114 shared

Similar researchers at Ohio State University

• Vadim Fedorovh-53
• Sissy M. Jhiangh-45
• Isabelle Deschenesh-44