Teruo Okano

About

Teruo Okano is a faculty member at the College of Pharmacy, specifically associated with the Department of Molecular Pharmaceutics. His research focus involves molecular pharmaceutics, contributing to the development and understanding of pharmaceutical sciences. The page indicates his role within the department and his contact information, but does not provide detailed information about his background, specific research contributions, or key achievements.

Research topics

• Biology
• Medicine
• Pathology
• Cell biology
• Anatomy
• Chemistry
• Biomedical engineering
• Surgery
• Bioinformatics
• Immunology

Selected publications

• 3D cell sheet structure augments mesenchymal stem cell cytokine production

  Scientific Reports · 2021 · 87 citations

  Senior authorCorresponding

  Mesenchymal stem cells (MSCs) secrete paracrine factors that play crucial roles during tissue regeneration. An increasing body of evidence suggests that this paracrine function is enhanced by MSC cultivation in three-dimensional (3D) tissue-like microenvironments. Toward this end, this study explored scaffold-free cell sheet technology as a new 3D platform. MSCs cultivated on temperature-responsive culture dishes to a confluent 2D monolayer were harvested by temperature reduction from 37 to 20 °…

  DOI

• Trends in Articular Cartilage Tissue Engineering: 3D Mesenchymal Stem Cell Sheets as Candidates for Engineered Hyaline-Like Cartilage

  Cells · 2021 · 55 citations

  Senior authorCorresponding

  Articular cartilage defects represent an inciting factor for future osteoarthritis (OA) and degenerative joint disease progression. Despite multiple clinically available therapies that succeed in providing short term pain reduction and restoration of limited mobility, current treatments do not reliably regenerate native hyaline cartilage or halt cartilage degeneration at these defect sites. Novel therapeutics aimed at addressing limitations of current clinical cartilage regeneration therapies in…

  DOI

• Interferon-Gamma Primed Human Clonal Mesenchymal Stromal Cell Sheets Exhibit Enhanced Immunosuppressive Function

  Cells · 2022-11-23 · 29 citations

  articleOpen accessSenior authorCorresponding

  Mesenchymal stromal cells (MSCs) represent a promising treatment for immune-related diseases due to their diverse immunomodulatory paracrine functions. However, progress of culture-expanded MSCs is hindered by inconsistent cell function, poor localization, and insufficient retention when administered as suspended cell injections, thus placing spatiotemporal dosing constraints on therapeutic functions. To address these limitations, we introduce the combination of in vitro interferon-gamma (IFN-γ)…

  PublisherOA PDFDOI

• Safety and efficacy of human juvenile chondrocyte-derived cell sheets for osteochondral defect treatment

  npj Regenerative Medicine · 2021 · 27 citations

  Senior authorCorresponding

  Knee cartilage does not regenerate spontaneously after injury, and a gold standard regenerative treatment algorithm has not been established. This study demonstrates preclinical safety and efficacy of scaffold-free, human juvenile cartilage-derived-chondrocyte (JCC) sheets produced from routine surgical discards using thermo-responsive cultureware. JCCs exhibit stable and high growth potential in vitro over passage 10, supporting possibilities for scale-up to mass production for commercializatio…

  PublisherOA PDFDOI

• Polydactyly-derived allogeneic chondrocyte cell-sheet transplantation with high tibial osteotomy as regenerative therapy for knee osteoarthritis

  npj Regenerative Medicine · 2022-12-16 · 26 citations

  articleOpen access

  Allogeneic cell therapies are not fully effective in treating osteoarthritis of the knee (OAK). We recently reported that transplantation of autologous chondrocyte cell-sheets along with open-wedge high tibial osteotomy promoted hyaline cartilage repair in humans. Here we describe our regenerative therapy for OAK using polydactyly-derived allogeneic chondrocyte cell-sheets (PD sheets) and temperature-responsive culture inserts. Ten patients with OAK and cartilage defects categorized arthroscopic…

  PublisherOA PDFDOI

Frequent coauthors

• Masayuki Yamato

  Tohoku University Hospital

  620 shared

• Akihiko Kikuchi

  Social Insurance Saitama Chuo Hospital

  404 shared

• Tatsuya Shimizu

  Tokyo Women's Medical University

  256 shared

• Jun Kobayashi

  Josai University

  211 shared

• Yoshikatsu Akiyama

  Tokyo Women's Medical University

  178 shared

• Yasuhisa Sakurai

  Mitsui Memorial Hospital

  155 shared

• Hideko Kanazawa

  Keio University

  147 shared

• Kazunori Kataoka

  Johns Hopkins University

  144 shared

Education

• Ph.D., Polymer Chemistry

  Waseda University

  1979

• M.S., Polymer Chemistry

  Waseda University

  1976

• B.S., Applied Chemistry

  Waseda University

  1974

Similar researchers at University of Utah

• Jindrich Kopecekh-91
• David Graingerh-76
• Huiqian Huh-54