David Grainger
· ProfessorUniversity of Utah · Department of Pharmaceutics & Pharmaceutical Chemistry
Active 1961–2026
Academic metrics are sourced from OpenAlex and public funding records; values may differ from Google Scholar.
About
David Grainger is a faculty member in the Department of Molecular Pharmaceutics at the College of Pharmacy. His email contact is David.Grainger@hsc.utah.edu. The page does not provide specific details about his research focus, background, or key contributions.
Research topics
- Medicine
- Biology
- Computer Science
- Pathology
- Artificial Intelligence
- Anatomy
- Cell biology
- Biomedical engineering
- Chemistry
- Knowledge management
Selected publications
Acta Biomaterialia · 2021 · 92 citations
3D cell sheet structure augments mesenchymal stem cell cytokine production
Scientific Reports · 2021 · 87 citations
Mesenchymal stem cells (MSCs) secrete paracrine factors that play crucial roles during tissue regeneration. An increasing body of evidence suggests that this paracrine function is enhanced by MSC cultivation in three-dimensional (3D) tissue-like microenvironments. Toward this end, this study explored scaffold-free cell sheet technology as a new 3D platform. MSCs cultivated on temperature-responsive culture dishes to a confluent 2D monolayer were harvested by temperature reduction from 37 to 20 °…
Cells · 2021 · 55 citations
Articular cartilage defects represent an inciting factor for future osteoarthritis (OA) and degenerative joint disease progression. Despite multiple clinically available therapies that succeed in providing short term pain reduction and restoration of limited mobility, current treatments do not reliably regenerate native hyaline cartilage or halt cartilage degeneration at these defect sites. Novel therapeutics aimed at addressing limitations of current clinical cartilage regeneration therapies in…
Journal of the American Medical Informatics Association · 2020 · 39 citations
Clinical decision-making is based on knowledge, expertise, and authority, with clinicians approving almost every intervention-the starting point for delivery of "All the right care, but only the right care," an unachieved healthcare quality improvement goal. Unaided clinicians suffer from human cognitive limitations and biases when decisions are based only on their training, expertise, and experience. Electronic health records (EHRs) could improve healthcare with robust decision-support tools th…
npj Regenerative Medicine · 2021 · 27 citations
Knee cartilage does not regenerate spontaneously after injury, and a gold standard regenerative treatment algorithm has not been established. This study demonstrates preclinical safety and efficacy of scaffold-free, human juvenile cartilage-derived-chondrocyte (JCC) sheets produced from routine surgical discards using thermo-responsive cultureware. JCCs exhibit stable and high growth potential in vitro over passage 10, supporting possibilities for scale-up to mass production for commercializatio…
Recent grants
NIH · $100k · 1999
NIH · $2.8M · 2013
NIH · $634k · 2003
Frequent coauthors
- 200 shared
Barbara Luke
- 161 shared
Judy E. Stern
Dartmouth Psychiatric Research Center
- 154 shared
Marcelle I. Cedars
University of California, San Francisco
- 150 shared
N.A. Klein
- 132 shared
William R. Meyer
- 132 shared
John F. Steege
University of North Carolina at Chapel Hill
- 131 shared
Franklin D. Loffer
- 130 shared
Lisa Peacock
Louisiana State University Health Sciences Center New Orleans
Labs
Mei LabPI
Education
- 1987
Ph.D., Pharmaceutical Chemistry
University of Utah
- 1983
B.A.; Engineering modified with Chemistry, Engineering
Dartmouth College
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