Jindrich Kopecek
· ProfessorUniversity of Utah · Department of Pharmaceutics & Pharmaceutical Chemistry
Active 1967–2025
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Research topics
- Medicine
- Biology
- Immunology
- Biochemistry
- Cancer research
- Chemistry
- Pharmacology
- Materials science
- Cell biology
- Molecular biology
Selected publications
Advanced Drug Delivery Reviews · 2020 · 125 citations
1st authorCorrespondingAdvanced Functional Materials · 2020 · 116 citations
surface receptor crosslinking, and produces prolonged elimination of PD-L1 rather than the transient blocking afforded by standard anti-PD-L1 antibodies. Together, these findings established the polymer-facilitated tumor targeting of immunogenic drugs and surface crosslinking of PD-L1 as a potential new therapeutic strategy to propagate a long-term antitumor immunity, which might broaden the application of immunotherapy to immunosuppressive cancers.
Journal of Controlled Release · 2019-12-30 · 53 citations
articleSenior authorCorrespondingBroadening and Enhancing Functions of Antibodies by Self-Assembling Multimerization at Cell Surface
ACS Nano · 2019-09-25 · 33 citations
articleOpen accessSenior authorCorresponding) hybridizes with surface-attached OBN-MORF1, manipulates CD20 clustering, and engages additional signals to induce calcium influx and caspase-related apoptosis. With the two types of different mechanisms collaborating in one system, the simple design exerted a notable survival extension of mice bearing disseminated B-cell lymphomas.
Nanomedicines in B cell-targeting therapies
Acta Biomaterialia · 2021 · 26 citations
Senior authorCorresponding
Recent grants
NIH · $1.5M · 2013
NIH · $117k · 2007
NIH · $1.4M · 2006
Frequent coauthors
- 151 shared
Pavla Kopečková
- 90 shared
Jiyuan Yang
- 41 shared
Karel Ulbrich
Czech Academy of Sciences, Institute of Macromolecular Chemistry
- 40 shared
Ruth Duncan
- 30 shared
Blanka Řı́hová
Czech Academy of Sciences, Institute of Microbiology
- 25 shared
Huaizhong Pan
Utah Department of Health
- 25 shared
J. Strohalm
Czech Academy of Sciences, Institute of Macromolecular Chemistry
- 23 shared
Scott C. Miller
Labs
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