About

Sushant Ranadive is an Associate Professor in the Department of Kinesiology at the University of Maryland School of Public Health. His primary research interests include studying the mechanisms related to the higher prevalence of hypertension in postmenopausal women compared to age-matched men. He specifically focuses on neurovascular control mechanisms in both pre and post-menopausal women that are either unstudied or understudied. Currently, his projects concentrate on racial and sex disparities in vascular function following acute inflammation. Dr. Ranadive's educational background includes a Ph.D. in Kinesiology from the University of Illinois at Urbana Champaign, an M.S. in Exercise Physiology from the University of Illinois at Chicago, and a B.S. in Occupational Therapy from Seth G.S. Medical College and KEM Hospital. His work aims to advance understanding of inflammation, cardiovascular physiology, racial differences, women's health, sex hormones, and vascular physiology.

Research topics

• Medicine
• Internal medicine
• Endocrinology

Selected publications

• Natural Fluctuations in Progesterone Do Not Impact Vascular Function in Healthy Premenopausal Women

  The FASEB Journal · 2021

  Senior authorCorresponding
  • Internal medicine
  • Endocrinology
  • Medicine

  Endogenous sex hormone concentrations vary across the menstrual cycle of naturally menstruating premenopausal women and may elicit concomitant changes in vascular function. Specifically, estrogen (E2) may enhance vascular function, partially by increasing nitric oxide bioavailability. In contrast, the influence of progesterone (P4) on vascular function remains unclear, with some data suggesting it increases nitric oxide bioavailability and other data suggesting it antagonizes the dilatory effects of E2. The objective of the study was to elucidate potential effects of P4 on the macrovascular function of healthy premenopausal women in the presence of relatively lower E2 concentrations. It was hypothesized that measures of macrovascular function would be similar between the early follicular (EF) and early luteal (EL) phases of healthy premenopausal women, despite a significant increase in the progesterone‐to‐estrogen ratio from the EF to the EL phase. Sex hormones and vascular function were measured in ten healthy premenopausal women (22±2 y) during the EF phase (within 5 days of the onset of menstruation) and the EL phase (4±2 days post‐ovulation) of a single menstrual cycle. Serum concentrations of E2 and P4 were analyzed using enzyme‐linked immunosorbent assays. Independent concentrations of E2 and P4 were calculated, as well as P4:E2. Macrovascular function was assessed via brachial artery flow‐mediated dilation (FMD). %FMD was calculated as the percent change in brachial artery diameter following an ischemic stimulus. Data were compared between phases with paired t‐tests. Serum concentrations of E2 and P4 increased from the EF to the EL phase (91.8±34.5 vs. 120.9±32.6 pg/mL, p=0.01 and 1.4±0.6 vs. 5.1±3.6 ng/mL, p=0.01, respectively). The P4:E2 increased significantly from the EF to the EL phase as a result of the P4 surge in the EL phase (15.5±4.8 vs. 42.9±30.5, p=0.02). %FMD did not differ between the EF and EL phases (9.6±4.4 vs. 9.5±3.5 %, p=0.97). In conclusion, the macrovascular function of healthy premenopausal women is similar between the EF and EL phases despite significant increases in the P4:E2. Findings may suggest that P4 does not play an antagonist role on E2 and may have a synergistic effect on increasing %FMD among decreased concentrations of E2.

  DOI

• Changes in circulating microRNA and arterial stiffness following high‐intensity interval and moderate intensity continuous exercise

  Physiological Reports · 2020 · 21 citations

  • Medicine
  • Cardiology
  • Internal medicine

  High-intensity interval (HII) exercise elicits distinct vascular responses compared to a matched dose of moderate intensity continuous (MOD) exercise. However, the acute effects of HII compared to MOD exercise on arterial stiffness are incompletely understood. Circulating microRNAs (ci-miRs) may contribute to the vascular effects of exercise. We sought to determine exercise intensity-dependent changes in ci-miR potentially underlying changes in arterial stiffness. Ten young, healthy men underwent well-matched, 30-min HII and MOD exercise bouts. RT-qPCR was used to determine the levels of seven vascular-related ci-miRs in serum obtained immediately before and after exercise. Arterial stiffness measures including carotid to femoral pulse wave velocity (cf-PWV), carotid arterial compliance and β-stiffness, and augmentation index (AIx and AIx75) were taken before, 10min after and 60min after exercise. Ci-miR-21-5p, 126-3p, 126-5p, 150-5p, 155-5p, and 181b-5p increased after HII exercise (p < .05), while ci-miR-150-5p and 221-3p increased after MOD exercise (p = .03 and 0.056). One hour after HII exercise, cf-PWV trended toward being lower compared to baseline (p = .056) and was significantly lower compared to 60min after MOD exercise (p = .04). Carotid arterial compliance was increased 60min after HII exercise (p = .049) and was greater than 60min after MOD exercise (p = .02). AIx75 increased 10 min after both HII and MOD exercise (p < .05). There were significant correlations between some of the exercise-induced changes in individual ci-miRs and changes in cf-PWV and AIx/AIx75. These results support the hypotheses that arterial stiffness and ci-miRs are altered in an exercise intensity-dependent manner, and ci-miRs may contribute to changes in arterial stiffness.

  DOI

Frequent coauthors

• Abbi D. Lane

  University of Michigan–Ann Arbor

  20 shared

• Bo Fernhall

  University of Massachusetts Boston

  20 shared

• Huimin Yan

  Chinese PLA General Hospital

  17 shared

• Lindy M. Rossow

  Maryville University

  14 shared

• Gavin P. Horn

  Fire Safety Research Institute

  14 shared

• Christopher A. Fahs

  Logan University

  14 shared

• Michael J. Joyner

  Mayo Clinic in Florida

  9 shared

• Stamatis Agiovlastis

  Skidmore College

  9 shared

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