Siri Atma W. Greeley

About

Dr. Siri Atma W. Greeley, MD, PhD, is an Associate Professor of Pediatrics and Medicine at the University of Chicago and serves as a Principal Investigator for studies on Neonatal Diabetes at the Kovler Diabetes Center. He is a pediatric endocrinologist specializing in the treatment of infants, children, and teens with all types of diabetes. Dr. Greeley's research focuses on the classification of diabetes type in individual patients, with a particular interest in monogenic diabetes. His work aims to improve understanding and treatment of diabetes in young patients through precise diagnosis and tailored therapeutic approaches.

Research topics

• Medicine
• Endocrinology
• Internal medicine
• Intensive care medicine
• Political Science
• Genetics
• Biology
• Pediatrics
• Family medicine
• Pathology

Selected publications

• Second international consensus report on gaps and opportunities for the clinical translation of precision diabetes medicine

  Nature Medicine · 2023 · 194 citations

  Precision medicine is part of the logical evolution of contemporary evidence-based medicine that seeks to reduce errors and optimize outcomes when making medical decisions and health recommendations. Diabetes affects hundreds of millions of people worldwide, many of whom will develop life-threatening complications and die prematurely. Precision medicine can potentially address this enormous problem by accounting for heterogeneity in the etiology, clinical presentation and pathogenesis of common…

  PublisherOA PDFDOI

• ISPAD Clinical Practice Consensus Guidelines 2022: The diagnosis and management of monogenic diabetes in children and adolescents

  Pediatric Diabetes · 2022 · 184 citations

  1st authorCorresponding
  DOI

• Update of variants identified in the pancreatic β‐cell K _ATP channel genes <i>KCNJ11</i> and <i>ABCC8</i> in individuals with congenital hyperinsulinism and diabetes

  Human Mutation · 2020 · 170 citations

  The most common genetic cause of neonatal diabetes and hyperinsulinism is pathogenic variants in ABCC8 and KCNJ11. These genes encode the subunits of the β-cell ATP-sensitive potassium channel, a key component of the glucose-stimulated insulin secretion pathway. Mutations in the two genes cause dysregulated insulin secretion; inactivating mutations cause an oversecretion of insulin, leading to congenital hyperinsulinism, whereas activating mutations cause the opposing phenotype, diabetes. This r…

  DOI

• Precision subclassification of type 2 diabetes: a systematic review

  Communications Medicine · 2023 · 92 citations

  BACKGROUND: Heterogeneity in type 2 diabetes presentation and progression suggests that precision medicine interventions could improve clinical outcomes. We undertook a systematic review to determine whether strategies to subclassify type 2 diabetes were associated with high quality evidence, reproducible results and improved outcomes for patients. METHODS: We searched PubMed and Embase for publications that used 'simple subclassification' approaches using simple categorisation of clinical chara…

  PublisherOA PDFDOI

• Precision gestational diabetes treatment: a systematic review and meta-analyses

  Communications Medicine · 2023 · 29 citations

  BACKGROUND: Gestational Diabetes Mellitus (GDM) affects approximately 1 in 7 pregnancies globally. It is associated with short- and long-term risks for both mother and baby. Therefore, optimizing treatment to effectively treat the condition has wide-ranging beneficial effects. However, despite the known heterogeneity in GDM, treatment guidelines and approaches are generally standardized. We hypothesized that a precision medicine approach could be a tool for risk-stratification of women to stream…

  PublisherOA PDFDOI

Recent grants

• Monogenic Diabetes: Next Generation Diagnosis, Treatment and Complications

  NIH · $4.7M · 2016–2024

• NIH Grant K23DK094866

  NIH · $515k · 2015

• NIH Grant R03DK103096

  NIH · $149k · 2017

Frequent coauthors

• Louis H. Philipson

  University of Chicago

  83 shared

• Rochelle N. Naylor

  University of Chicago

  63 shared

• Lisa R. Letourneau

  University of Chicago

  54 shared

• Cécile Saint‐Martin

  Assistance Publique – Hôpitaux de Paris

  53 shared

• Jacques Beltrand

  Sorbonne Paris Cité

  53 shared

• Norbert Stefan

  Deutsches Diabetes-Zentrum e.V.

  52 shared

• Feifei Cheng

  Dalian Medical University

  51 shared

• Róbert Wágner

  Heinrich Heine University Düsseldorf

  50 shared

Labs

• Siri Atma W. Greeley LabPI

Education

• B.S., Chemistry and Bioengineering

  Columbia University

  1995

• Ph.D., Immunology

  University of Pennsylvania

  2002

• M.D.

  University of Pennsylvania

  2003

• M.D., Pediatrics

  The University of Chicago Comer Children's Hospital

  2006

• M.D., Pediatric Endocrinology

  The University of Chicago Comer Children's Hospital

  2009

Awards & honors

• 3rd DMDEA Gold Medal Oration Award Dr. Mohan’s Diabetes Educ…
• Early Career Development Award Central Society for Clinical…
• Ira Rosenthal Memorial Lecture University of Illinois at Chi…
• Lewis-Sebring Family Foundation Fellow in Diabetes Genetics…
• The George M. Eisenberg Foundation for Charities Excellence…

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