Shyni Varghese

About

Shyni Varghese is a Professor of Biomedical Engineering, Mechanical Engineering & Materials Science, and Orthopaedic Surgery at Duke University. She is the Principal Investigator of the Varghese Lab, where her research focuses on the development of smart bioimaterials, miniature organs, and rejuvenation techniques, aiming to translate bench research to bedside applications. Her work involves interdisciplinary approaches to advance regenerative medicine and biomaterials, contributing to innovative solutions in tissue engineering and regenerative therapies.

Research topics

• Biology
• Chemistry
• Immunology
• Materials science
• Medicine
• Nanotechnology
• Biomedical engineering
• Computer Science
• Internal medicine
• Cell biology

Selected publications

• Resolution of inflammation in bone regeneration: From understandings to therapeutic applications

  Biomaterials · 2021 · 274 citations

  Senior authorCorresponding
  DOI

• Rationally Designed Anisotropic and Auxetic Hydrogel Patches for Adaptation to Dynamic Organs

  Advanced Functional Materials · 2022 · 64 citations

  Abstract Current hydrogel or fabric patches for organ repair are generally not designed to conform to the complex mechanics of dynamic organs such as the lung or heart. This study presents a new, biocompatible and bilayered, hydrogel‐based patch platform, consisting of a non‐fouling top layer and a cell adhesive bottom layer, that caters to the anisotropic and auxetic characteristics of dynamic organs. Integrated computational and experimental studies are used to screen over 116 unique anisotrop…

  DOI

• Bone targeting nanocarrier-assisted delivery of adenosine to combat osteoporotic bone loss

  Biomaterials · 2021 · 49 citations

  Senior authorCorresponding
  DOI

• Spinal cord repair is modulated by the neurogenic factor Hb-egf under direction of a regeneration-associated enhancer

  Nature Communications · 2023-08-11 · 45 citations

  articleOpen access

  Unlike adult mammals, zebrafish regenerate spinal cord tissue and recover locomotor ability after a paralyzing injury. Here, we find that ependymal cells in zebrafish spinal cords produce the neurogenic factor Hb-egfa upon transection injury. Animals with hb-egfa mutations display defective swim capacity, axon crossing, and tissue bridging after spinal cord transection, associated with disrupted indicators of neuron production. Local recombinant human HB-EGF delivery alters ependymal cell cyclin…

  PublisherOA PDFDOI

• Progress in the design and synthesis of viscosupplements for articular joint lubrication

  Current Opinion in Colloid & Interface Science · 2023-05-26 · 23 citations

  articleSenior authorCorresponding
  PublisherDOI

Recent grants

• NIH Grant R01AR06318402

  NIH · $329k · 2018

• NIH Grant R01AR06318401A1

  NIH · $329k · 2018

• I-Corps: 3D Organ on a Chip

  NSF · $50k · 2015–2016

Frequent coauthors

• Yu‐Ru V. Shih

  Duke University

  72 shared

• Aereas Aung

  University of Toronto

  59 shared

• Nathaniel S. Hwang

  Seoul National University

  48 shared

• Vardhman Kumar

  Duke University

  43 shared

• Yongsung Hwang

  Soonchunhyang University

  43 shared

• Jennifer H. Elisseeff

  Johns Hopkins Medicine

  41 shared

• Jomkuan Theprungsirikul

  Duke University

  37 shared

• Shruti K. Davey

  34 shared

Labs

• Varghese LabPI

  Current lab members

Similar researchers at Duke University

• Michael Rod Zalutskyh-85
• Matthew L Beckerh-60
• Bastiaan Driehuysh-53