Bastiaan Driehuys

About

Bastiaan Driehuys is a Professor of Radiology and Biomedical Engineering at Duke University. His research focuses on magnetic resonance imaging (MRI) with hyperpolarized 129Xe gas, a technology he has helped develop for high-resolution, non-invasive imaging of pulmonary function. His work is at the forefront of this novel imaging technique, which enhances MRI signals by a factor of 100,000 through laser-based hyperpolarization, enabling detailed visualization of lung health and disease. Driehuys's research program involves multiple NIH and industry-sponsored studies, and his team is working towards clinical implementation following recent FDA approval of the technology. His studies aim to improve early diagnosis and monitoring of interstitial and pulmonary vascular diseases, collaborating closely with pulmonary medicine colleagues. He provides research opportunities for Ph.D., Masters, medical, and undergraduate students, contributing significantly to the advancement of pulmonary MRI.

Research topics

• Medicine
• Internal medicine
• Radiology
• Physics
• Computer Science
• Nuclear medicine
• Nuclear magnetic resonance
• Thermodynamics
• Medical physics
• Physical therapy

Selected publications

• Using hyperpolarized ¹²⁹Xe gas-exchange MRI to model the regional airspace, membrane, and capillary contributions to diffusing capacity

  Journal of Applied Physiology · 2021 · 39 citations

  Senior authorCorresponding

  correlates strongly with measured values in 142 subjects with a broad range of pulmonary disorders.

  DOI

• Establishing standardized healthy reference distributions and values for multisite <scp> ¹²⁹ Xe </scp> gas exchange <scp>MRI</scp> / <scp>MR spectroscopy</scp> at 3 T across major scanner platforms

  Magnetic Resonance in Medicine · 2025-06-02 · 5 citations

  articleOpen accessSenior authorCorresponding

  Abstract Purpose To establish standardized reference distributions and values for 1‐point Dixon 129 Xe gas exchange MRI/MR spectroscopy (MRS) in a multicenter healthy cohort of 18–30‐year‐olds scanned on three major 3T platforms. These distributions and values enable consistent, quantitative analysis and interpretation of images and spectra. Methods Healthy participants from three centers—Duke University (Siemens), Cincinnati Children's Hospital (Philips), and the University of Iowa (General Ele…

  PublisherOA PDFDOI

• The Age-dependent Upper Limit of Normal for Hyperpolarized 129Xe MRI Ventilation Defect Percent in Healthy Individuals Using a Multi-center Database

  American Journal of Respiratory and Critical Care Medicine · 2025-05-01 · 3 citations

  article

  Abstract Rationale: Hyperpolarized 129Xe magnetic resonance imaging (129XeMRI) is an innovative, clinically approved imaging technique that provides novel insights into lung structure and function such as the ventilation defect percent (VDP). An upper limit of normal (ULN) for VDP has previously been proposed (McIntosh et al, 2023), but ULN accounting for variations in age as well as imaging sites, scanner platforms, and acquisition protocols remain undefined. We aimed to determine the ULN for V…

  PublisherDOI

• A Systematic Review of the Variability of Ventilation Defect Percent Generated From Hyperpolarized Noble Gas Pulmonary Magnetic Resonance Imaging

  Journal of Magnetic Resonance Imaging · 2025-02-26 · 2 citations

  reviewOpen access

  ABSTRACT Hyperpolarized (HP) gas pulmonary MR ventilation images are typically quantified using ventilation defect percent (VDP); however, the test‐retest variability of VDP has not been systematically established in multi‐center trials. Herein, we perform a systematic review of the test‐retest literature on the variability of VDP, and similar metrics, generated from HP MRI. This review utilizes the Medline, EMBASE, and EBM Reviews databases and includes studies that assessed the variability of…

  PublisherOA PDFDOI

• The emerging role of hyperpolarized ¹²⁹ Xe MRI in pulmonary hypertension

  Expert Review of Respiratory Medicine · 2025-07-02 · 1 citations

  editorialOpen access
  PublisherOA PDFDOI

Recent grants

• Early Detection of Changes in Pulmonary Gas Exchange by Hyperpolarized Xe MRI

  NIH · $6.0M · 2011–2027

• Xenon MRI in Pulmonary Hypertension

  NIH · $2.9M · 2021–2026

• NIH Grant P41RR005959

  NIH · $4.6M · 2013

Frequent coauthors

• Mu He

  Nanjing University of Information Science and Technology

  87 shared

• Elianna Bier

  77 shared

• Rohan S. Virgincar

  71 shared

• David Mummy

  Duke University

  70 shared

• H. Page McAdams

  66 shared

• Scott H. Robertson

  64 shared

• Zackary I. Cleveland

  63 shared

• Ziyi Wang

  Hainan University

  62 shared

Labs

• Bastiaan Driehuys LabPI

  Not provided

Similar researchers at Duke University

• Michael Rod Zalutskyh-85
• Shyni Vargheseh-66
• Matthew L Beckerh-60