Jennifer Elisseeff

About

Jennifer Elisseeff is the F. Stuart Hodgson Department Head of the Department of Chemical and Biomolecular Engineering at Johns Hopkins University, with an appointment in the Department of Biomedical Engineering. She is the founder of the Translational Tissue Engineering Center at the Johns Hopkins Department of Biomedical Engineering and the Wilmer Eye Institute, where she served as director from 2010 until 2023. Elisseeff is a pioneer in the development and commercial translation of injectable biomaterials for regenerative therapies. Her research areas include regenerative immunology, biomaterials, aging, and arthritis. She is the first Johns Hopkins faculty member to be elected to all three national academies—the National Academy of Engineering, the National Academy of Medicine, and the National Academy of Science. Elisseeff serves on the scientific advisory boards of Bausch and Lomb, Kythera Biopharmaceutical, and Cellular Bioengineering Inc. She has received numerous awards, including the Carnegie Mellon Young Alumni Award, Arthritis Investigator Award from the Arthritis Foundation, Yasuda Award from the Society of Physical Regulation in Medicine and Biology, and recognition as a top innovator under 35 by Technology Review magazine. She was elected a fellow in the American Institute for Medical and Biological Engineering and a Young Global Leader in the World Economic Forum. Elisseeff has published over 200 articles, book chapters, and patent applications, and has given…

Research topics

• Cancer research
• Medicine
• Immunology
• Chemistry
• Pharmacology
• Biology
• Biochemistry
• Cell biology
• Internal medicine
• Pathology

Selected publications

• Using proteolysis-targeting chimera technology to reduce navitoclax platelet toxicity and improve its senolytic activity

  Nature Communications · 2020 · 254 citations

  Small molecules that selectively kill senescent cells (SCs), termed senolytics, have the potential to prevent and treat various age-related diseases and extend healthspan. The use of Bcl-xl inhibitors as senolytics is largely limited by their on-target and dose-limiting platelet toxicity. Here, we report the use of proteolysis-targeting chimera (PROTAC) technology to reduce the platelet toxicity of navitoclax (also known as ABT263), a Bcl-2 and Bcl-xl dual inhibitor, by converting it into PZ1522…

  PublisherOA PDFDOI

• IL-17 and immunologically induced senescence regulate response to injury in osteoarthritis

  Journal of Clinical Investigation · 2020 · 247 citations

  Senior authorCorresponding

  Senescent cells (SnCs) are implicated in the pathogenesis of age-related diseases including osteoarthritis (OA), in part via expression of a senescence-associated secretory phenotype (SASP) that includes immunologically relevant factors and cytokines. In a model of posttraumatic OA (PTOA), anterior cruciate ligament transection (ACLT) induced a type 17 immune response in the articular compartment and draining inguinal lymph nodes (LNs) that paralleled expression of the senescence marker p16INK4a…

  DOI

• Distinct myeloid-derived suppressor cell populations in human glioblastoma

  Science · 2025-01-16 · 83 citations

  articleOpen access

  The role of glioma-associated myeloid cells in tumor growth and immune evasion remains poorly understood. We performed single-cell RNA sequencing of immune and tumor cells from 33 gliomas, identifying two distinct myeloid-derived suppressor cell (MDSC) populations in isocitrate dehydrogenase-wild-type (IDT-WT) glioblastoma: an early progenitor MDSC (E-MDSC) population with up-regulation of metabolic and hypoxia pathways and a monocytic MDSC (M-MDSC) population. Spatial transcriptomics demonstrat…

  PublisherOA PDFDOI

• Transcriptomic analysis of skeletal muscle regeneration across mouse lifespan identifies altered stem cell states

  Nature Aging · 2024-11-22 · 34 citations

  articleOpen access

  In aging, skeletal muscle regeneration declines due to alterations in both myogenic and non-myogenic cells and their interactions. This regenerative dysfunction is not understood comprehensively or with high spatiotemporal resolution. We collected an integrated atlas of 273,923 single-cell transcriptomes and high-resolution spatial transcriptomic maps from muscles of young, old and geriatric mice (~5, 20 and 26 months old) at multiple time points following myotoxin injury. We identified eight im…

  PublisherDOI

• Immunometabolic cues recompose and reprogram the microenvironment around implanted biomaterials

  Nature Biomedical Engineering · 2024-10-04 · 27 citations

  articleOpen access
  PublisherOA PDFDOI

Recent grants

• Single cell characterization of the biomaterial immune and stromal response

  NIH · $2.5M · 2020–2025

• Biomaterials-directed regenerative immunotherapies

  NIH · $5.7M · 2019–2025

• NIH Grant R01AR054005

  NIH · $2.5M · 2015

Frequent coauthors

• Drew M. Pardoll

  Johns Hopkins University

  164 shared

• Franck Housseau

  Sidney Kimmel Comprehensive Cancer Center

  159 shared

• Liam Chung

  Johns Hopkins University

  146 shared

• Matthew T. Wolf

  National Cancer Institute

  132 shared

• Elana J. Fertig

  Sidney Kimmel Comprehensive Cancer Center

  123 shared

• Ada Tam

  Johns Hopkins University

  122 shared

• Kaitlyn Sadtler

  National Institute of Biomedical Imaging and Bioengineering

  114 shared

• David R. Maestas

  University of Pittsburgh

  89 shared

Labs

• Elisseeff LabPI

  Not provided

Awards & honors

• Carnegie Mellon Young Alumni Award
• Arthritis Investigator Award from the Arthritis Foundation
• Yasuda Award from the Society of Physical Regulation in Medi…
• Top Innovator Under 35 by Technology Review magazine (2002)
• Top 10 Technologies to Change the Future by Technology Revie…

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