Richard Jones

About

Richard Jones is a Professor of Psychiatry and Human Behavior, as well as a Professor of Neurology at Brown University. He is an epidemiologist and methodologist who leads the Quantitative Science Program (QSP) at the Brown University Warren Alpert Medical School, within the Departments of Psychiatry and Human Behavior and Neurology. His primary research interests focus on the cognitive reserve hypothesis in relation to cognitive aging, dementia, Alzheimer’s disease, and delirium, alongside measurement and methodological approaches in clinical neurosciences. His work involves investigating neuroimaging markers of brain reserve, assessing cognitive performance, and understanding the neurophysiological underpinnings of delirium, often utilizing advanced statistical and measurement models such as item response theory, structural equation modeling, and longitudinal data analysis. Dr. Jones's contributions extend to developing instruments for delirium assessment, exploring the long-term cognitive trajectories following major surgery, and applying digital health tools to study behavioral and lifestyle factors affecting health outcomes. His research aims to improve understanding of neurodegenerative and neuropsychiatric conditions, ultimately contributing to better diagnosis, assessment, and intervention strategies in aging and neurological disorders.

Research topics

• Medicine
• Psychology
• Neuroscience
• Political Science
• Computer Science
• Sociology
• Biology
• Genetics
• Anthropology
• Internal medicine

Selected publications

• Estimating the Prevalence of Dementia and Mild Cognitive Impairment in the US

  JAMA Neurology · 2022 · 459 citations

  Importance: Nationally representative data are critical for understanding the causes, costs, and outcomes associated with dementia and mild cognitive impairment (MCI) in the US and can inform policies aimed at reducing the impact of these conditions on patients, families, and public programs. The nationally representative Health and Retirement Study (HRS) is an essential resource for such data, but the HRS substudy providing dementia diagnostic information was fielded more than 20 years ago and…

  DOI

• One-Year Medicare Costs Associated With Delirium in Older Patients Undergoing Major Elective Surgery

  JAMA Surgery · 2021 · 232 citations

  Importance: Delirium is a common, serious, and potentially preventable problem for older adults, associated with adverse outcomes. Coupled with its preventable nature, these adverse sequelae make delirium a significant public health concern; understanding its economic costs is important for policy makers and health care leaders to prioritize care. Objective: To evaluate current 1-year health care costs attributable to postoperative delirium in older patients undergoing elective surgery. Design,…

  DOI

• Education differentially contributes to cognitive reserve across racial/ethnic groups

  Alzheimer s & Dementia · 2020 · 111 citations

  INTRODUCTION: We examined whether educational attainment differentially contributes to cognitive reserve (CR) across race/ethnicity. METHODS: A total of 1553 non-Hispanic Whites (Whites), non-Hispanic Blacks (Blacks), and Hispanics in the Washington Heights-Inwood Columbia Aging Project (WHICAP) completed structural magnetic resonance imaging. Mixture growth curve modeling was used to examine whether the effect of brain integrity indicators (hippocampal volume, cortical thickness, and white matt…

  DOI

• Human neurons from Christianson syndrome iPSCs reveal mutation-specific responses to rescue strategies

  Science Translational Medicine · 2021 · 31 citations

  exchanger 6 (NHE6). To hasten treatment development, we established induced pluripotent stem cell (iPSC) lines from patients with CS representing a mutational spectrum, as well as biologically related and isogenic control lines. We demonstrated that pathogenic mutations lead to loss of protein function by a variety of mechanisms: The majority of mutations caused loss of mRNA due to nonsense-mediated mRNA decay; however, a recurrent, missense mutation (the G383D mutation) had both loss-of-functio…

  PublisherOA PDFDOI

• Recommended best practices for construct-centered adaptation of the Harmonized Cognitive Assessment Protocol

  The Journals of Gerontology Series B · 2025-10-24 · 6 citations

  articleOpen access

  OBJECTIVES: The Harmonized Cognitive Assessment Protocol (HCAP) neuropsychological assessment approach aims to support the collection of harmonizable data on cognitive function for cross-national cognitive aging and dementia research. As the measurement of cognition is sensitive to differences in contextual, cultural, educational, linguistic, social, and other factors that may influence cognitive test performance, HCAP requires adaptation to be appropriate for the contexts in which it is adminis…

  PublisherDOI

Recent grants

• NIH Grant R03AG025262

  NIH · $127k · 2008

• NIDUS II: Advanced-Stage Development and Utilization of the NIDUS Research Infrastructure to Advance Interdisciplinary Aging Research in Delirium

  NIH · $4.0M · 2021–2027

• NIH Grant R03AG017680

  NIH · $35k · 2001

Frequent coauthors

• Sharon K. Inouye

  Beth Israel Deaconess Medical Center

  1229 shared

• Edward R. Marcantonio

  Harvard University

  1160 shared

• Tamara G. Fong

  Harvard University

  792 shared

• Thomas G. Travison

  Hebrew SeniorLife

  487 shared

• Eva M. Schmitt

  Hebrew SeniorLife

  428 shared

• Tammy T. Hshieh

  Dana-Farber Brigham Cancer Center

  406 shared

• Long Ngo

  Beth Israel Deaconess Medical Center

  314 shared

• David C. Alsop

  295 shared

Labs

• Quantitative Sciences Program of the Departments of Psychiatry and Neurology at the Alpert Medical School of Brown University (QSP)PI

Education

• ScD, Mental Hygiene, NIMH Training Program in Psychiatric Epidemiology

  Johns Hopkins University

  1998

• BA, Psychology

  George Washington University

  1991

Similar researchers at Brown University

• Karen Furieh-148
• Rena Wingh-146
• Lawrence Priceh-132