Pratap Challa

About

Pratap Challa is a Professor of Ophthalmology and serves as the Residency Program Director in the Department of Ophthalmology at Duke University. He is based in the Wadsworth Building in Durham, North Carolina. His professional role includes overseeing residency training in ophthalmology, contributing to the education and development of future ophthalmologists within the Duke Department of Ophthalmology. His work is integral to the department's mission of providing comprehensive eye care, advancing ophthalmic education, and supporting research initiatives.

Research topics

• Medicine
• Ophthalmology
• Internal medicine
• Biology
• Chemistry
• Endocrinology
• Cell biology
• Meteorology
• Anesthesia
• Physics

Selected publications

• Anti-fibrotic activity of a rho-kinase inhibitor restores outflow function and intraocular pressure homeostasis

  eLife · 2021 · 64 citations

  Glucocorticoids are widely used as an ophthalmic medication. A common, sight-threatening adverse event of glucocorticoid usage is ocular hypertension, caused by dysfunction of the conventional outflow pathway. We report that netarsudil, a rho-kinase inhibitor, decreased glucocorticoid-induced ocular hypertension in patients whose intraocular pressures were poorly controlled by standard medications. Mechanistic studies in our established mouse model of glucocorticoid-induced ocular hypertension s…

  DOI

• Netarsudil Improves Trabecular Outflow Facility in Patients with Primary Open Angle Glaucoma or Ocular Hypertension: A Phase 2 Study

  American Journal of Ophthalmology · 2021 · 52 citations

  DOI

• Special Commentary: Reporting Clinical Endpoints in Studies of Minimally Invasive Glaucoma Surgery

  Ophthalmology · 2024-08-08 · 37 citations

  article
  PublisherDOI

• Long-Term Decrease of Intraocular Pressure in Rats by Viral Delivery of miR-146a

  Translational Vision Science & Technology · 2021 · 19 citations

  Purpose: To evaluate the effects of miR-146a in trabecular meshwork (TM) cells and on intraocular pressure (IOP) in vivo via viral delivery of miR-146a to the anterior chamber of rat eyes. Methods: Human TM cells were transfected with miR-146 mimic or inhibitor. Some cells from each group were then subjected to cyclic mechanical stress (CMS). Other cells from each group had no force applied. Gene expression was then analyzed by quantitative polymerase chain reaction (qPCR). Replication-deficient…

  PublisherDOI

• Infections and glaucoma

  Survey of Ophthalmology · 2021-09-03 · 16 citations

  review
  PublisherDOI

Recent grants

• NIH Grant K23EY014019

  NIH · $931k · 2009

Frequent coauthors

• R. Rand Allingham

  119 shared

• Leon W. Herndon

  Duke University

  111 shared

• David L. Epstein

  84 shared

• Paul P. Lee

  Wayne State University

  77 shared

• Sandra S. Stinnett

  Duke University

  68 shared

• Michael A. Hauser

  Duke University

  62 shared

• Sanjay Asrani

  57 shared

• Julia Song

  Southern California Eye Institute

  53 shared

Similar researchers at Duke University

• Edward George Buckleyh-53
• Xi Chenh-35