Nathanael Gray

About

Stephen C. Harrison is a Professor of Biological Chemistry and Molecular Pharmacology who played a central role in guiding the Harvard Biochemical Sciences Tutorial program for decades, including serving as Head Tutor from 1972-1996. His contributions emphasize the importance of teaching students how to think about scientific problems and how discoveries emerge from evidence. Harrison's work and philosophy have been integral to the program's focus on developing scientific thinking through discussion, mentorship, and engagement with primary scientific literature, fostering an environment where students learn to interpret experiments and understand scientific evidence.

Research topics

• Biology
• Cell biology
• Computer Science
• Computational biology
• Biochemistry
• Chemistry
• Genetics
• Cancer research
• Medicine
• Bioinformatics

Selected publications

• Partitioning of cancer therapeutics in nuclear condensates

  Science · 2020 · 517 citations

  The nucleus contains diverse phase-separated condensates that compartmentalize and concentrate biomolecules with distinct physicochemical properties. Here, we investigated whether condensates concentrate small-molecule cancer therapeutics such that their pharmacodynamic properties are altered. We found that antineoplastic drugs become concentrated in specific protein condensates in vitro and that this occurs through physicochemical properties independent of the drug target. This behavior was als…

  PublisherOA PDFDOI

• Treatment-Induced Tumor Dormancy through YAP-Mediated Transcriptional Reprogramming of the Apoptotic Pathway

  Cancer Cell · 2020 · 466 citations

  DOI

• Rapid and direct control of target protein levels with VHL-recruiting dTAG molecules

  Nature Communications · 2020 · 306 citations

  Senior authorCorresponding

  -1 overcomes a limitation of previously reported CRBN-recruiting dTAG molecules to degrade recalcitrant oncogenes, supports combination degrader studies and facilitates investigations of protein function in cells and mice.

  DOI

• Sulfopin is a covalent inhibitor of Pin1 that blocks Myc-driven tumors in vivo

  Nature Chemical Biology · 2021 · 147 citations

  DOI

• Selective Mediator dependence of cell-type-specifying transcription

  Nature Genetics · 2020 · 138 citations

  DOI

Recent grants

• NIH Grant T32CA009361

  NIH · $13.0M · 2017

• Degrading therapeutically important kinases using small molecules

  NIH · $3.9M · 2018–2029

• Development of covalent PIP4K2 inhibitors for the treatment of p53 deficient lung tumors

  NIH · $541k · 2015–2020

Frequent coauthors

• Pasi A. Jänne

  469 shared

• Kwok‐Kin Wong

  459 shared

• Tinghu Zhang

  Stanford University

  377 shared

• Nicholas Kwiatkowski

  334 shared

• Jinhua Wang

  307 shared

• Jianming Zhang

  Shanghai Jiao Tong University

  299 shared

• Qingsong Liu

  Chinese Academy of Sciences

  276 shared

• Jarrod A. Marto

  Dana-Farber Cancer Institute

  256 shared

Labs

• Harvard’s Biochemical Sciences Tutorial ProgramPI

Similar researchers at Harvard University

• David Livingstonh-177
• Stephen Harrisonh-162
• Joshua Sanesh-157