Joshua Sanes

About

Stephen C. Harrison is a Professor of Biological Chemistry and Molecular Pharmacology who played a central role in guiding the Harvard Biochemical Sciences Tutorial program for decades, including serving as Head Tutor from 1972-1996. His contributions emphasize the importance of learning how to think about scientific problems and how discoveries emerge from evidence. Harrison has been involved in mentoring students through the tutorial program, which focuses on developing intellectual relationships with practicing scientists, reading research papers, and discussing experiments and scientific concepts. His work has helped shape the educational approach that emphasizes discussion, mentorship, and engagement with primary scientific literature, fostering critical thinking and scientific inquiry among undergraduate students.

Research topics

• Biology
• Genetics
• Neuroscience
• Cell biology
• Medicine
• Anatomy
• Computational biology
• Pathology
• Virology
• Immunology

Selected publications

• Single-cell meta-analysis of SARS-CoV-2 entry genes across tissues and demographics

  Nature Medicine · 2021 · 372 citations

  cells in nasal, lung and gut tissues included genes that may mediate viral entry, key immune functions and epithelial-macrophage cross-talk, such as genes involved in the interleukin-6, interleukin-1, tumor necrosis factor and complement pathways. Cell-type-specific expression patterns may contribute to the pathogenesis of COVID-19, and our work highlights putative molecular pathways for therapeutic intervention.

  PublisherOA PDFDOI

• Mouse Retinal Cell Atlas: Molecular Identification of over Sixty Amacrine Cell Types

  Journal of Neuroscience · 2020 · 355 citations

  Senior authorCorresponding

  The mouse retina is a leading model for analyzing the development, structure, function, and pathology of neural circuits. A complete molecular atlas of retinal cell types provides an important foundation for these studies. We used high-throughput single-cell RNA sequencing to characterize the most heterogeneous class of retinal interneurons, amacrine cells, identifying 63 distinct types. The atlas includes types identified previously as well as many novel types. We provide evidence for the use o…

  DOI

• Synaptic Specificity, Recognition Molecules, and Assembly of Neural Circuits

  Cell · 2020 · 353 citations

  1st authorCorresponding
  DOI

• Optimizing Nervous System-Specific Gene Targeting with Cre Driver Lines: Prevalence of Germline Recombination and Influencing Factors

  Neuron · 2020 · 196 citations

  PublisherOA PDFDOI

• Evolution of neuronal cell classes and types in the vertebrate retina

  Nature · 2023-12-13 · 194 citations

  articleOpen access

  Abstract The basic plan of the retina is conserved across vertebrates, yet species differ profoundly in their visual needs 1 . Retinal cell types may have evolved to accommodate these varied needs, but this has not been systematically studied. Here we generated and integrated single-cell transcriptomic atlases of the retina from 17 species: humans, two non-human primates, four rodents, three ungulates, opossum, ferret, tree shrew, a bird, a reptile, a teleost fish and a lamprey. We found high mo…

  PublisherDOI

Recent grants

• NIH Grant R01NS076467

  NIH · $9.4M · 2016

• NIH Grant R01NS029172

  NIH · $2.5M · 2006

• NIH Grant P30NS062685

  NIH · $13.7M · 2019

Frequent coauthors

• Karthik Shekhar

  University of California, Berkeley

  88 shared

• R. Mark Grady

  St. Louis Children's Hospital

  64 shared

• Jeff W. Lichtman

  Harvard University

  48 shared

• Aviv Regev

  Broad Institute

  45 shared

• Wenjun Yan

  Stanford University

  42 shared

• Masahito Yamagata

  Harvard University

  41 shared

• Guoping Feng

  Broad Institute

  37 shared

• Kevin P. Campbell

  University of Florida

  37 shared

Labs

• Harvard’s Biochemical Sciences Tutorial ProgramPI

Education

• B.A., Biochemistry and Psychology

  Yale University

  1970

• Ph.D., Neuroscience

  Harvard University

Awards & honors

• 2024 Gerard Prize from the Society for Neuroscience

Similar researchers at Harvard University

• Nathanael Grayh-185
• David Livingstonh-177
• Stephen Harrisonh-162