Jarrod Marto

About

Jarrod Marto is a Professor of Chemistry in the School of Arts & Sciences and also holds the position of Professor of Biochemistry & Molecular Genetics in the School of Medicine. His research focuses on understanding the complex interactions between proteins, nucleotides, and metabolites within cells and tissues, particularly in the context of human disease. His laboratory develops and employs mass spectrometry, chemical, and genetic tools to investigate how DNA alterations and pathological insults influence cellular biochemical and signaling networks, with the goal of identifying therapeutic targets and developing molecular diagnostics for early detection, prognosis, and patient stratification. Marto's work involves leveraging quantitative proteomic data, including protein expression, isoform regulation, biochemical interactions, and post-translational modifications, to explore molecular mechanisms in disease and to identify new chemical probes and drug targets. His multidisciplinary and collaborative approach integrates synthetic and medicinal chemistry, structural and chemical biology, functional genomics, computational bioinformatics, and advanced instrumentation to support proteome-scale analyses in cell lines, clinical tissues, and single-cell contexts.

Research topics

• Biology
• Genetics
• Cell biology
• Cancer research
• Computational biology
• Chemistry
• Biochemistry
• Botany
• Molecular biology

Selected publications

• MassIVE MSV000100749 - SEC62-mediated control of HLA-E enables immune evasion in Diffuse Large B-Cell Lymphoma

  2026-01-01

  datasetOpen access1st authorCorresponding
  OA PDFDOI

• PRM-LIVE with Trapped Ion Mobility Spectrometry and Its Application in Selectivity Profiling of Kinase Inhibitors

  UNC Libraries · 2025-10-10

  articleOpen access

  Parallel reaction monitoring (PRM) has emerged as a popular approach for targeted protein quantification. With high ion utilization efficiency and first-in-class acquisition speed, the timsTOF Pro provides a powerful platform for PRM analysis. However, sporadic chromatographic drift in peptide retention time represents a fundamental limitation for the reproducible multiplexing of targets across PRM acquisitions. Here, we present PRM-LIVE, an extensible, Python-based acquisition engine for the ti…

  PublisherDOI

Recent grants

• NIH Grant R21CA178860

  NIH · $412k · 2015

• (PQ5) Contribution of mitochondrial pathways to metabolic heterogeneity in molecular subtypes of Diffuse Large B Cell Lymphoma

  NIH · $2.8M · 2018–2024

• Novel Screening Platform for Discovery of DUB Targeting Probes

  NIH · $630k · 2019–2023

Frequent coauthors

• Scott B. Ficarro

  Harvard University

  666 shared

• Guillaume Adelmant

  Dana-Farber Cancer Institute

  283 shared

• Nathanael S. Gray

  Dana-Farber Cancer Institute

  256 shared

• Tinghu Zhang

  Stanford University

  122 shared

• Manor Askenazi

  N2 Biomedical (United States)

  87 shared

• Pasi A. Jänne

  74 shared

• Lewis C. Cantley

  Dana-Farber Cancer Institute

  69 shared

• Nicholas Kwiatkowski

  68 shared

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