N. Scott Adzick

About

N. Scott Adzick is a Professor of Surgery in the Department of Surgery at the University of Pennsylvania's Perelman School of Medicine. He is affiliated with the Children’s Hospital of Philadelphia. His educational background includes an A.B. in History and Science from Harvard College (1975), an M.D. from Harvard University (1979), and a Master of Medical Management from Carnegie Mellon University (2003). His professional focus is on pediatric surgery, with particular expertise in fetal surgery and prenatal repair of congenital conditions such as myelomeningocele. Dr. Adzick has contributed to the field through research and clinical practice, including conducting randomized trials on prenatal versus postnatal repair of myelomeningocele and exploring fetal surgery for various congenital anomalies.

Research topics

• Physical therapy
• Pediatrics
• Surgery
• Medicine
• Internal medicine
• Psychiatry

Selected publications

• Prenatal Repair of Myelomeningocele and School-age Functional Outcomes

  PEDIATRICS · 2020 · 144 citations

  BACKGROUND AND OBJECTIVES: The Management of Myelomeningocele Study (MOMS), a randomized trial of prenatal versus postnatal repair for myelomeningocele, found that prenatal surgery resulted in reduced hindbrain herniation and need for shunt diversion at 12 months of age and better motor function at 30 months. In this study, we compared adaptive behavior and other outcomes at school age (5.9-10.3 years) between prenatal versus postnatal surgery groups. METHODS: Follow-up cohort study of 161 child…

  DOI

• Prenatal Repair and Physical Functioning Among Children With Myelomeningocele

  JAMA Pediatrics · 2021 · 84 citations

  Importance: The Management of Myelomeningocele Study (MOMS), a randomized clinical trial of prenatal vs standard postnatal repair for myelomeningocele, found that prenatal repair reduced hydrocephalus and hindbrain herniation and improved motor function in children aged 12 to 30 months. The Management of Myelomeningocele Study Follow-up (MOMS2) was conducted in children at ages 5 to 10 years. The primary (neurocognitive) outcome has already been reported. Objective: To determine whether MOMS2 pa…

  DOI

• A Randomized Trial of Prenatal versus Postnatal Repair of Myelomeningocele

  2023-12-12 · 13 citations

  book-chapter1st authorCorresponding

  Eligible women recruited from three American fetal medicine centers either underwent prenatal surgery before 26 weeks of gestation or standard postnatal repair. There were two primary outcomes: a composite of fetal or neonatal death or the need for placement of a cerebrospinal fluid shunt by the age of 12 months and a composite of mental development and motor function at 30 months. The trial was stopped for efficacy of prenatal surgery after the recruitment of 183 of a planned 200 patients. The…

  PublisherDOI

• The Delivery Room Resuscitation of Infants with Congenital Diaphragmatic Hernia Treated with Fetoscopic Endoluminal Tracheal Occlusion: Beyond the Balloon

  Fetal Diagnosis and Therapy · 2024-01-01 · 12 citations

  articleOpen access

  INTRODUCTION: Randomized controlled trials found that fetoscopic endoluminal tracheal occlusion (FETO) resulted in increased fetal lung volume and improved survival for infants with isolated, severe left-sided congenital diaphragmatic hernia (CDH). The delivery room resuscitation of these infants is particularly unique, and the specific delivery room events are largely unknown. The objective of this study was to compare the delivery room resuscitation of infants treated with FETO to standard of…

  PublisherOA PDFDOI

• Sonographic Predictors of Survival in Fetal Diaphragmatic Hernia

  2023-12-12 · 12 citations

  book-chapterSenior author

  The authors studied the predictive value of detailed fetal sonographic parameters on outcomes for 55 patients with prenatally diagnosed congenital diaphragmatic hernia managed at an extracorporeal membrane oxygenation center. Their sonographic assessment included gestational age at time of diagnosis, polyhydramnios (largest amniotic fluid pocket diameter), presence of liver and/or stomach herniation and abdominal circumference at the level of the umbilical cord. This series is from the original…

  PublisherDOI

Recent grants

• NIH Grant U01HD068541

  NIH · $6.7M · 2018

• NIH Grant U10HD041666

  NIH · $6.0M · 2012

• NIH Grant R01HD025505

  NIH · $1.5M · 1998

Frequent coauthors

• Alan W. Flake

  Children's Hospital of Philadelphia

  432 shared

• Mark P. Johnson

  Rolls-Royce (United Kingdom)

  331 shared

• Holly L. Hedrick

  Children's Hospital of Philadelphia

  302 shared

• Lori J. Howell

  Children's Hospital of Philadelphia

  249 shared

• Timothy M. Crombleholme

  Connecticut Children's Medical Center

  217 shared

• Enrico Danzer

  Stanford University

  159 shared

• Michael R. Harrison

  University of California, San Francisco

  145 shared

• Leslie N. Sutton

  University of Pennsylvania

  133 shared

Education

• B.A., History and Science

  Harvard College

  1975

• M.D.

  Harvard University

  1979

• Other

  Carnegie Mellon University

  2003

Similar researchers at University of Pennsylvania

• John Q. Trojanowskih-296
• Craig B. Thompsonh-277
• Daniel J Raderh-236