Murray Grossman

About

Murray Grossman, M.D., Ed.D., is a faculty member in the Department of Neurology at the Perelman School of Medicine at the University of Pennsylvania. His research focuses on biomarker studies in neurodegenerative diseases, particularly assessing behavioral, imaging, and biofluid measures in patients with frontotemporal degeneration spectrum disorders, including primary progressive aphasia, behavioral variant FTD, amyotrophic lateral sclerosis, corticobasal degeneration, and progressive supranuclear palsy. He also studies parkinson spectrum disorders with the goal of identifying the most reflective behavioral, neuroimaging, and biofluid measures of underlying proteinopathy in these patient groups, and participates in clinical treatment trials. Grossman's clinical expertise includes young-onset neurodegenerative conditions such as frontotemporal degeneration spectrum disorders, parkinson spectrum disorders like Parkinson's disease and Lewy body disease, corticobasal degeneration, progressive supranuclear palsy, and amyotrophic lateral sclerosis. He is the director of the Penn Frontotemporal Degeneration Center.

Research topics

• Medicine
• Biology
• Neuroscience
• Psychology
• Pathology
• Internal medicine
• Radiology
• Genetics
• Computer Science
• Artificial Intelligence

Selected publications

• Distribution patterns of tau pathology in progressive supranuclear palsy

  Acta Neuropathologica · 2020 · 459 citations

  Progressive supranuclear palsy (PSP) is a 4R-tauopathy predominated by subcortical pathology in neurons, astrocytes, and oligodendroglia associated with various clinical phenotypes. In the present international study, we addressed the question of whether or not sequential distribution patterns can be recognized for PSP pathology. We evaluated heat maps and distribution patterns of neuronal, astroglial, and oligodendroglial tau pathologies and their combinations in different clinical subtypes of…

  DOI

• Neurofilament Light Chain as a Biomarker for Cognitive Decline in Parkinson Disease

  Movement Disorders · 2021 · 170 citations

  BACKGROUND: Neurofilament light chain protein (NfL) is a promising biomarker of neurodegeneration. OBJECTIVES: To determine whether plasma and CSF NfL (1) associate with motor or cognitive status in Parkinson's disease (PD) and (2) predict future motor or cognitive decline in PD. METHODS: Six hundred and fifteen participants with neurodegenerative diseases, including 152 PD and 200 healthy control participants, provided a plasma and/or cerebrospinal fluid (CSF) NfL sample. Diagnostic groups were…

  DOI

• Utility of the global CDR^® plus NACC FTLD rating and development of scoring rules: Data from the ARTFL/LEFFTDS Consortium

  Alzheimer s & Dementia · 2020 · 161 citations

  INTRODUCTION: plus NACC FTLD to detect and track early frontotemporal lobar degeneration (FTLD) and to conduct clinical trials in FTLD. METHODS: The CDR plus NACC FTLD rating was applied to 970 sporadic and familial participants from the baseline visit of Advancing Research and Treatment in Frontotemporal Lobar Degeneration (ARTFL)/Longitudinal Evaluation of Familial Frontotemporal Dementia Subjects (LEFFTDS). Each of the eight domains of the CDR plus NACC FTLD was equally weighed in determining…

  DOI

• Autosomal dominant VCP hypomorph mutation impairs disaggregation of PHF-tau

  Science · 2020 · 141 citations

  is an autosomal-dominant genetic mutation associated with neurofibrillary degeneration in part owing to reduced tau disaggregation, raising the possibility that VCP may represent a therapeutic target for the treatment of AD.

  DOI

• Temporal order of clinical and biomarker changes in familial frontotemporal dementia

  Nature Medicine · 2022 · 131 citations

  DOI

Recent grants

• NIH Grant R01AG038490

  NIH · $2.1M · 2018

• NIH Grant P50NS053488

  NIH · $33.7M · 2018

• NIH Grant R01NS044266

  NIH · $6.8M · 2016

Frequent coauthors

• John Q. Trojanowski

  University of Pennsylvania

  598 shared

• David J. Irwin

  University of Pennsylvania

  546 shared

• Corey T. McMillan

  University of Pennsylvania

  379 shared

• Bruce L. Miller

  University Memory and Aging Center

  327 shared

• Vivianna M. Van Deerlin

  University of Pennsylvania

  313 shared

• Virginia M.‐Y. Lee

  California University of Pennsylvania

  257 shared

• David A. Wolk

  California University of Pennsylvania

  219 shared

• Lauren Elman

  University of Pennsylvania

  215 shared

Education

• Resident, Neurology

  Hospital of the University of Pennsylvania

  1989

• intern, Medicine

  Royal Victoria Hospital

  1986

• postdoctoral fellowship, Brain Sciences

  Massachusetts Institute of Technology

  1981

• EdD, Aphasia Research Center

  Boston University

  1977

Similar researchers at University of Pennsylvania

• Craig B. Thompsonh-277
• Daniel J Raderh-236