Michael John Allingham

About

Michael John Allingham is an Assistant Professor of Ophthalmology at Duke University. His professional role involves clinical and research activities within the Department of Ophthalmology, focusing on vitreoretinal disease. He is associated with the Duke Pediatric Retina and Optic Nerve Center (DPROC) and is engaged in advancing understanding and treatment of retinal conditions. His work is situated within a comprehensive ophthalmology program that includes various specialized divisions such as Glaucoma, Cornea, and Neuro-Ophthalmology, among others. Based at Duke University, he contributes to the department's mission of education, research, and patient care in ophthalmology.

Research topics

• Medicine
• Ophthalmology
• Internal medicine
• Bioinformatics
• Pathology
• Biology
• Surgery

Selected publications

• Incomplete response to Anti-VEGF therapy in neovascular AMD: Exploring disease mechanisms and therapeutic opportunities

  Progress in Retinal and Eye Research · 2020 · 361 citations

  PublisherOA PDFDOI

• Deep learning-based single-shot prediction of differential effects of anti-VEGF treatment in patients with diabetic macular edema

  Biomedical Optics Express · 2020 · 77 citations

  Anti-vascular endothelial growth factor (VEGF) agents are widely regarded as the first line of therapy for diabetic macular edema (DME) but are not universally effective. An automatic method that can predict whether a patient is likely to respond to anti-VEGF therapy can avoid unnecessary trial and error treatment strategies and promote the selection of more effective first-line therapies. The objective of this study is to automatically predict the efficacy of anti-VEGF treatment of DME in indiv…

  PublisherDOI

• A Quantitative Approach to Predict Differential Effects of Anti-VEGF Treatment on Diffuse and Focal Leakage in Patients with Diabetic Macular Edema: A Pilot Study

  Translational Vision Science & Technology · 2017-03-21 · 45 citations

  articleOpen access1st authorCorresponding

  Purpose: We use semiautomated segmentation of fluorescein angiography (FA) to determine whether anti-vascular endothelial growth factor (VEGF) treatment for diabetic macular edema (DME) differentially affects microaneurysm (MA)–associated leakage, termed focal leakage, versus non-MA–associated leakage, termed diffuse leakage. Methods: We performed a retrospective study of 29 subjects treated with at least three consecutive injections of anti-VEGF agents for DME (mean 4.6 injections; range, 3–10)…

  PublisherOA PDFDOI

• Enhanced visualization of peripheral retinal vasculature with wavefront sensorless adaptive optics optical coherence tomography angiography in diabetic patients

  Optics Letters · 2016-12-15 · 34 citations

  articleCorresponding

  Optical coherence tomography angiography (OCTA) is a promising technique for non-invasive visualization of vessel networks in the human eye. We debut a system capable of acquiring wide field-of-view (>70°) OCT angiograms without mosaicking. Additionally, we report on enhancing the visualization of peripheral microvasculature using wavefront sensorless adaptive optics (WSAO). We employed a fast WSAO algorithm that enabled wavefront correction in <2 s by iterating the mirror shape at the speed of…

  PublisherDOI

• Phase 1 Clinical Trial of Elamipretide in Intermediate Age-Related Macular Degeneration and High-Risk Drusen

  Ophthalmology Science · 2021 · 29 citations

  1st authorCorresponding

  Purpose: To assess safety, tolerability, and feasibility of subcutaneous administration of the mitochondrial-targeted drug elamipretide in patients with intermediate age-related macular degeneration (AMD) and high-risk drusen (HRD) and to perform exploratory analyses of change in visual function. Design: Phase 1, single-center, open-label, 24-week clinical trial with preplanned HRD cohort. Participants: Adult patients ≥55 years of age with intermediate AMD and HRD. Methods: Participants received…

  PublisherOA PDFDOI

Recent grants

• Muller glial dysfunction in retinal edema

  NIH · $639k · 2016–2020

Frequent coauthors

• Scott W. Cousins

  29 shared

• Sina Farsiu

  Duke University

  29 shared

• Priyatham S. Mettu

  25 shared

• Cynthia A. Toth

  Duke University

  14 shared

• Sharon F. Freedman

  Duke Medical Center

  13 shared

• Du Tran-Viet

  Duke University

  12 shared

• Rachelle V. O’Connell

  12 shared

• Ramiro S. Maldonado

  Duke University

  12 shared

Similar researchers at Duke University

• Edward George Buckleyh-53
• Sanjay Girdhari Asranih-43
• Pratap Challah-41