Massimo Costalonga

About

Eric Schiffman, DDS, MS, is a Professor and the Director of Clinical Research in the School of Dentistry at the University of Minnesota. He has received over $19 million in research funding from the National Institutes of Health (NIH) and has authored over 60 peer-reviewed publications, 12 book chapters, and holds 3 patents with another pending. His past research as an NIH study principal investigator includes developing and publishing validated Diagnostic Criteria for Temporomandibular Disorders (DC/TMD) for the most common TMD, applicable in both clinical and research settings. He has also conducted research on TMD management, assessing the long-term effectiveness of medical management versus comprehensive rehabilitation with and without TMJ surgery in patients with symptomatic TMJ closed lock and limited mouth opening. Additionally, he has studied the longitudinal impact of intra-articular TMJ disorders on jaw pain, function, and disability. His work in the NIH-funded National Dental Practice-Based Research Network involved evaluating how dentists manage TMD patients in their practices. His recent projects include developing and clinically testing the Restful Jaw device, a device attached to dental chairs designed to support the jaw during dental procedures, including third molar surgeries.

Research topics

• Biology
• Medicine
• Pathology
• Dentistry
• Immunology
• Gastroenterology
• Microbiology
• Materials science
• Internal medicine
• Biochemistry

Selected publications

• No evidence for colonization of oral bacteria in the distal gut in healthy adults

  Proceedings of the National Academy of Sciences · 2021 · 72 citations

  ), the two niches are completely distinct. Thus, there is no evidence for colonization of oral bacteria in the distal gut. This defines the healthy state to which pathological states could be compared. Finding the same bacteria in the mouth and stool may warrant clinical investigation for an underlying pathology.

  PublisherDOI

• Placental colonization with periodontal pathogens: the potential missing link

  American Journal of Obstetrics and Gynecology · 2019-04-30 · 68 citations

  reviewSenior authorCorresponding
  PublisherDOI

• Unravelling the Oral–Gut Axis: Interconnection Between Periodontitis and Inflammatory Bowel Disease, Current Challenges, and Future Perspective

  Journal of Crohn s and Colitis · 2024-02-28 · 52 citations

  reviewOpen access

  As the opposite ends of the orodigestive tract, the oral cavity and the intestine share anatomical, microbial, and immunological ties that have bidirectional health implications. A growing body of evidence suggests an interconnection between oral pathologies and inflammatory bowel disease [IBD], implying a shift from the traditional concept of independent diseases to a complex, reciprocal cycle. This review outlines the evidence supporting an 'oral-gut' axis, marked by a higher prevalence of per…

  PublisherOA PDFDOI

• Sclerostin and WNT‐5a gingival protein levels in chronic periodontitis and health

  Journal of Periodontal Research · 2019-04-14 · 39 citations

  articleOpen access

  BACKGROUND AND OBJECTIVE: Wnt signaling pathways regulate osteoblast differentiation and bone formation and are associated with inflammatory responses driven by innate and adaptive immunity via the NF-κB pathway. The aim of this study was to compare the levels of sclerostin (SOST), WNT-5a, and TNF-α between chronic periodontitis and periodontally healthy sites and determine their value as diagnostic markers of chronic periodontitis. MATERIAL AND METHODS: In a cross-sectional assessment 25 chroni…

  PublisherOA PDFDOI

• The root canal microbiome diversity and function. A whole‐metagenome shotgun analysis

  International Endodontic Journal · 2023-03-02 · 36 citations

  articleOpen accessCorresponding

  AIM: To evaluate the root canal microbiome composition and bacterial functional capability in cases of primary and secondary apical periodontitis utilizing whole-metagenome shotgun sequencing. METHODOLOGY: Twenty-two samples from patients with primary root canal infections, and 18 samples obtained from previously treated teeth currently diagnosed with apical periodontitis were analysed with whole-metagenome shotgun sequencing at a depth of 20 M reads. Taxonomic and functional gene annotations we…

  PublisherOA PDFDOI

Recent grants

• NIH Grant R21DE022858

  NIH · $418k · 2015

• NIH Grant R56DE014371

  NIH · $299k · 2012

• NIH Grant R01DE014371

  NIH · $774k · 2008

Frequent coauthors

• Lei Zhang

  Beijing Chaoyang Emergency Medical Center

  16 shared

• James E. Hinrichs

  University of Minnesota

  16 shared

• Erik P. Skoe

  University of Minnesota

  12 shared

• Prokopios P. Argyris

  The Ohio State University

  12 shared

• Conrado Aparicio

  Universitat Internacional de Catalunya

  12 shared

• Xi Chen

  Fujian Medical University

  12 shared

• Peter D. Bittner‐Eddy

  University of Minnesota

  11 shared

• Lori A. Fischer

  University of Minnesota

  9 shared

Labs

• Massimo Costalonga LaboratoryPI

Education

• Ph.D., Dental Sciences

  University of Minnesota

  2000

• Other, Dental Medicine

  University of Minnesota

  1996

Awards & honors

• Calprotectin-mediated CD69 signaling in periodontitis (2021…
• Calprotectin and CD69 affect regulatory T cell responses (20…
• MHC-II deficient Langerhans cells with compensatory Tc17 (20…
• Immunoregulatory role of PMN leukocytes in periodontitis (20…
• MyD88 and MHCII requirement in oral Langerhans cell to d (20…

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• Kristin Artingerh-35
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