David Bereiter

About

Eric Schiffman, DDS, MS, is a Professor and the Director of Clinical Research in the School of Dentistry at the University of Minnesota. He has received over $19 million in research funding from the National Institutes of Health (NIH) and has authored over 60 peer-reviewed publications, 12 book chapters, and holds 3 patents with another pending. His past research as an NIH study principal investigator includes developing and publishing validated Diagnostic Criteria for Temporomandibular Disorders (DC/TMD) for the most common TMD, applicable in both clinical and research settings. He has also conducted research on TMD management, assessing the long-term effectiveness of medical management versus comprehensive rehabilitation with and without TMJ surgery in patients with symptomatic TMJ closed lock and limited mouth opening. Additionally, his work includes studying the longitudinal impact of intra-articular TMJ disorders on jaw pain, function, and disability. Schiffman has contributed to the NIH-funded National Dental Practice-Based Research Network by evaluating how dentists manage TMD patients in their practices. His recent projects include developing and clinically testing the Restful Jaw device, a device attached to dental chairs designed to support the jaw during dental procedures, including third molar surgeries.

Research topics

• Medicine
• Internal medicine
• Chemistry
• Anesthesia
• Neuroscience
• Anatomy
• Pharmacology
• Surgery
• Endocrinology
• Biology

Selected publications

• TFOS DEWS II pain and sensation report

  The Ocular Surface · 2017-07-01 · 633 citations

  reviewOpen access
  PublisherOA PDFDOI

• TRPV1 and TRPM8 Channels and Nocifensive Behavior in a Rat Model for Dry Eye

  Investigative Ophthalmology & Visual Science · 2018-07-25 · 77 citations

  articleOpen access1st authorCorresponding

  Purpose: Persistent ocular surface pain occurs in moderate to severe dry eye disease (DE); however, the mechanisms that underlie this symptom remain uncertain. The aim of this study was to determine if the transient receptor potential vanilloid ion channels play a role in hypertonic saline (HS)-evoked corneal reflexes in a model for aqueous tear deficient DE. Methods: Eye wipe behavior and orbicularis oculi muscle activity (OOemg) were measured after ocular instillation of HS, capsaicin, or ment…

  PublisherOA PDFDOI

• Ascending projections of nociceptive neurons from trigeminal subnucleus caudalis: A population approach

  Experimental Neurology · 2017-03-31 · 61 citations

  article
  PublisherDOI

• Differential activation of ascending noxious pathways associated with trigeminal nerve injury

  Pain · 2019-02-08 · 36 citations

  article

  Trigeminal spinal subnucleus caudalis (Vc) neurons that project to the ventral posteromedial thalamic nucleus (VPM) and parabrachial nucleus (PBN) are critical for orofacial pain processing. We hypothesized that persistent trigeminal nerve injury differentially alters the proportion of Vc neurons that project to VPM and PBN in a modality-specific manner. Neuroanatomical approaches were used to quantify the number of Vc neurons projecting to VPM or PBN after chronic constriction injury of the inf…

  PublisherDOI

• Title: P2x7 Receptor Activation and Estrogen Status Drive Neuroinflammatory Mechanisms in a Rat Model for Dry Eye

  Frontiers in Pharmacology · 2022 · 17 citations

  1st authorCorresponding

  and NLRP3 expression compared to untreated DED females. Orbicularis oculi muscle activity (OOemg) evoked by ocular instillation of hypertonic saline (HS) was recorded as a surrogate measure of ocular hyperalgesia and was markedly enhanced in all DED groups compared to sham rats. Systemic minocycline reduced HS-evoked OOemg in all DED groups compared to sham rats. Local microinjection in the caudal trigeminal brainstem of an antagonist for P2X7R (A804598) greatly reduced HS-evoked OOemg activity…

  PublisherOA PDFDOI

Recent grants

• NIH Grant R01DE012758

  NIH · $5.1M · 2016

• NIH Grant R01NS026137

  NIH · $3.8M · 2009

• NIH Grant R01EY021447

  NIH · $1.5M · 2017

Frequent coauthors

• Charles B. Hathaway

  58 shared

• A. P. Benetti

  Rhode Island Hospital

  56 shared

• Keiichiro Okamoto

  Niigata University

  39 shared

• Donald S. Gann

  University of Maryland, Baltimore

  35 shared

• Harumitsu Hirata

  University of Illinois Urbana-Champaign

  29 shared

• Ian D. Meng

  University of New England

  25 shared

• R. Thompson

  19 shared

• Ayumu Tashiro

  Nanyang Technological University

  18 shared

Labs

• Oral Health Clinical Research CenterPI

Awards & honors

• Ocular Hyperalgesia in Dry Eye (2017 - 2022)
• Role of purinergic signaling and glia in TMJ nociception (20…
• Trigeminal-autonomic Relations in Ocular Homeostasis (2015 -…
• Estrogen and Psychological Stress in TMJD Pain (2012 - 2015)
• Trigeminal-autonomic Relations in Ocular Homeostasis (2011 -…

Similar researchers at University of Minnesota

• Kristin Artingerh-35
• Massimo Costalongah-19
• Mansur Ahmadh-16