Lee Ferguson

About

P. Lee Ferguson is a Professor of Civil and Environmental Engineering at Duke University. His research interests include environmental analytical chemistry and applications of high resolution mass spectrometry to trace organic contaminant analysis. He focuses on the environmental fate of per-and-polyfluorinated alkyl substances (PFAS), polymer additives, and microplastics in aquatic environments, as well as mechanisms of environmental endocrine disruption in aquatic organisms.

Research topics

• Chemistry
• Medicine
• Biology
• Biochemistry
• Internal medicine
• Cell biology

Selected publications

• Evaluation of Sirtuin Role in Neuroprotection of Retinal Ganglion Cells in Hypoxia

  Investigative Ophthalmology & Visual Science · 2012-06-06 · 42 citations

  article

  PURPOSE. Hypoxia-induced apoptosis is responsible for reduced retinal ganglion cell (RGC) viability in a variety of chronic ocular disorders. Sirtuin 1 (SIRT1) plays an important role in preserving cell viability during hypoxia. We investigated the role of SIRT1 in sustaining RGC viability in an in vitro model of hypoxia. METHODS. Staurosphorine-differentiated RGCs (RGC-5) received varying hypoxic concentrations (100-500 μM) of cobalt chloride (CoCl2) for 24 hours. Hypoxia-induced cell viability…

  PublisherDOI

• Metabolic functions of myo-inositol. II. Effect of inositol deficiency on the metabolism of nucleic acids of mammalian cells in tissue culture.

  PubMed · 1961-09-01 · 16 citations

  articleSenior author
  Publisher

• Deprivation of bFGF Promotes Spontaneous Differentiation of Human Embryonic Stem Cells into Retinal Pigment Epithelial Cells.

  PubMed · 2015-01-01 · 13 citations

  article1st authorCorresponding

  BACKGROUND: The retinal pigment epithelium (RPE), an important tissue monolayer of retina, sustains visual function and retinal homeostasis. In disease conditions such as Retinitis Pigmentosa (RP) and Age related Macular degeneration (AMD), the integrity and functional capacity of RPE monolayer is compromised. Human embryonic stem cells derived RPE (hESC-RPE) is ideal for cell based therapy because of their ability to morphologically and functionally mimic native fetal and adult RPE. However pro…

  Publisher

• 299 A CTS team approach to assess the in vitro toxicity of microplastic fibers to human lung epithelial cells cultured at an air-liquid interface

  Journal of Clinical and Translational Science · 2024 · 1 citations

  OBJECTIVES/GOALS: Our goal is to determine whether microplastic fibers (MPFs) provide signals for dendritic cell-induced Th2 polarization via epithelial-cell-derived thymic stromal lymphopoietin (TSLP). We seek to highlight a potential mechanism for MPF-induced airway toxicity associated with asthma exacerbation. METHODS/STUDY POPULATION: Primary human bronchial epithelial cells (NHBEs) were grown and differentiated at an air-liquid interface. Dyed and undyed polyester MPFs (14x45 µm) generated…

  PublisherOA PDFDOI

Frequent coauthors

• Sandeep Grover

  Post Graduate Institute of Medical Education and Research

  12 shared

• Sripriya Nannu Shankar

  Columbia University

  12 shared

• K V Chalam

  Loma Linda University Health Care

  11 shared

• Sankarathi Balaiya

  University of Florida

  11 shared

• Kakarla V Chalam

  Loma Linda University Health Care

  10 shared

• Chang‐Yu Wu

  University of Florida

  10 shared

• Tara-Sabo Attwood

  Vanderbilt University

  6 shared

• Amber O’Connor

  Multidisciplinary Association for Psychedelic Studies

  6 shared

Labs

• Ferguson LabPI

Awards & honors

• Applied Research Fellowship. North Carolina Department of En…
• Kavli Frontiers of Science Fellow. National Academy of Scien…
• Outstanding Performance Award. Fundamental Science Directora…
• President's Award to Distinguished Doctoral Students. Stony…
• Honorable Mention. National Science Foundation Graduate Fell…

Similar researchers at Duke University

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• Rhonda Adamsh-48
• Henri P Gavinh-27