Kenneth Adler

About

Kenneth Adler is associated with the College of Veterinary Medicine at NC State University. The page does not provide specific details about his research focus, background, or key contributions. Therefore, no further biographical information is available from the provided text.

Research topics

• Medicine
• Internal medicine
• Biology
• Chemistry
• Pathology
• Cancer research
• Anatomy
• Biochemistry
• Immunology
• Cell biology

Selected publications

• Inhalation of lung spheroid cell secretome and exosomes promotes lung repair in pulmonary fibrosis

  Nature Communications · 2020 · 432 citations

  Idiopathic pulmonary fibrosis (IPF) is a fatal and incurable form of interstitial lung disease in which persistent injury results in scar tissue formation. As fibrosis thickens, the lung tissue loses the ability to facilitate gas exchange and provide cells with needed oxygen. Currently, IPF has few treatment options and no effective therapies, aside from lung transplant. Here we present a series of studies utilizing lung spheroid cell-secretome (LSC-Sec) and exosomes (LSC-Exo) by inhalation to t…

  PublisherOA PDFDOI

• Targeting Myristoylated Alanine-Rich C Kinase Substrate Phosphorylation Site Domain in Lung Cancer. Mechanisms and Therapeutic Implications

  American Journal of Respiratory and Critical Care Medicine · 2014-10-15 · 71 citations

  article

  RATIONALE: Phosphorylation of myristoylated alanine-rich C kinase substrate (phospho-MARCKS) at the phosphorylation site domain (PSD) is crucial for mucus granule secretion and cell motility, but little is known concerning its function in lung cancer. OBJECTIVES: We aimed to determine if MARCKS PSD activity can serve as a therapeutic target and to elucidate the molecular basis of this potential. METHODS: The clinical relevance of phospho-MARCKS was first confirmed. Next, we used genetic approach…

  PublisherDOI

• Derivation of therapeutic lung spheroid cells from minimally invasive transbronchial pulmonary biopsies

  Respiratory Research · 2017-06-30 · 50 citations

  articleOpen access

  BACKGROUND: Resident stem and progenitor cells have been identified in the lung over the last decade, but isolation and culture of these cells remains a challenge. Thus, although these lung stem and progenitor cells provide an ideal source for stem-cell based therapy, mesenchymal stem cells (MSCs) remain the most popular cell therapy product for the treatment of lung diseases. Surgical lung biopsies can be the tissue source but such procedures carry a high risk of mortality. METHODS: In this stu…

  PublisherOA PDFDOI

• MARCKS and Lung Disease

  American Journal of Respiratory Cell and Molecular Biology · 2018-10-19 · 43 citations

  reviewSenior authorCorresponding

  /calmodulin and PKC signaling, and to sequester the signaling molecule phosphatidylinositol 4,5-bisphosphate in the plasma membrane. Since the mid-1980s, this evolutionarily conserved and ubiquitously expressed protein has been associated with regulating cellular events that require dynamic actin reorganization, including cellular adhesion, migration, and exocytosis. More recently, translational studies have implicated MARCKS in the pathophysiology of a number of airway diseases, including chron…

  PublisherDOI

• <scp>MARCKS</scp>‐dependent mucin clearance and lipid metabolism in ependymal cells are required for maintenance of forebrain homeostasis during aging

  Aging Cell · 2015-05-25 · 33 citations

  articleOpen access

  Ependymal cells (ECs) form a barrier responsible for selective movement of fluids and molecules between the cerebrospinal fluid and the central nervous system. Here, we demonstrate that metabolic and barrier functions in ECs decline significantly during aging in mice. The longevity of these functions in part requires the expression of the myristoylated alanine-rich protein kinase C substrate (MARCKS). Both the expression levels and subcellular localization of MARCKS in ECs are markedly transform…

  PublisherOA PDFDOI

Recent grants

• A novel therapeutic approach for Acute Lung Injury/ARDS

  NIH · $202k · 2014–2015

• NIH Grant P50HL014212

  NIH · $7.0M · 1992

• NIH Grant R01HL036982

  NIH · $3.8M · 2004

Frequent coauthors

• Linda D. Martin

  42 shared

• Nancy J. Akley

  37 shared

• Bernard M. Fischer

  34 shared

• Shijing Fang

  North Carolina State University

  32 shared

• Xiangdong Wang

  Zhongshan Hospital

  32 shared

• Joungjoa Park

  North Carolina State University

  31 shared

• Anne L. Crews

  North Carolina State University

  30 shared

• Janice A. Dye

  Environmental Protection Agency

  25 shared

Awards & honors

• MERIT Award from the National Heart, Lung, and Blood Institu…
• O. Max Gardner Award (2004)

Similar researchers at North Carolina State University

• Matthew Breenh-77
• Mark Papichh-63
• Ke Chengh-61