Ke Cheng

About

Sarah Ho is the CVM Director of Student Engagement at the College of Veterinary Medicine at NC State University. Her role involves fostering student development and engagement within the college community. The page highlights her contact information and her position as a key figure in student involvement, but does not provide specific details about her research focus, background, or key contributions in the field of veterinary medicine or biomedical sciences.

Research topics

• Medicine
• Biology
• Internal medicine
• Cancer research
• Pathology
• Cell biology
• Chemistry
• Bioinformatics
• Immunology
• Anatomy

Selected publications

• Inhalation of lung spheroid cell secretome and exosomes promotes lung repair in pulmonary fibrosis

  Nature Communications · 2020 · 432 citations

  Senior authorCorresponding

  Idiopathic pulmonary fibrosis (IPF) is a fatal and incurable form of interstitial lung disease in which persistent injury results in scar tissue formation. As fibrosis thickens, the lung tissue loses the ability to facilitate gas exchange and provide cells with needed oxygen. Currently, IPF has few treatment options and no effective therapies, aside from lung transplant. Here we present a series of studies utilizing lung spheroid cell-secretome (LSC-Sec) and exosomes (LSC-Exo) by inhalation to t…

  PublisherOA PDFDOI

• Tumor cell-derived exosomes home to their cells of origin and can be used as Trojan horses to deliver cancer drugs

  Theranostics · 2020 · 394 citations

  Senior authorCorresponding

  : Here we demonstrate that the exosomes' ability to target the parent cancer is a phenomenon that opens up new ways to devise targeted therapies to deliver anti-tumor drugs.

  DOI

• An off-the-shelf artificial cardiac patch improves cardiac repair after myocardial infarction in rats and pigs

  Science Translational Medicine · 2020 · 204 citations

  Senior authorCorresponding

  Cell therapy has been a promising strategy for cardiac repair after injury or infarction; however, low retention and engraftment of transplanted cells limit potential therapeutic efficacy. Seeding scaffold material with cells to create cardiac patches that are transplanted onto the surface of the heart can overcome these limitations. However, because patches need to be freshly prepared to maintain cell viability, long-term storage is not feasible and limits clinical applicability. Here, we devel…

  DOI

• A Zebrafish Model of Metastatic Colonization Pinpoints Cellular Mechanisms of Circulating Tumor Cell Extravasation

  Frontiers in Oncology · 2021 · 19 citations

  ) as consistently upregulated and central to the ECM gene regulatory network (p < 0.05). Versican expression is prognostic for a poorer metastasis-free and overall survival in patients with osteosarcoma. Together, our results provide a novel experimental framework to study discrete steps in the metastatic process. Using this system, we identify the versican/ECM network dysregulation as a potential contributor to osteosarcoma circulating tumor cell metastasis.

  DOI

• Plant-derived hydrogel and photosynthetic nano-units for myocardial infarction therapy

  Nature Communications · 2025-08-18 · 11 citations

  articleOpen access

  Ischemic injury and reperfusion injury collectively determine the total infarct size, a major prognostic factor following myocardial infarction (MI). Therefore, addressing both ischemic and reperfusion stages could substantially reduce infarct size and improve clinical outcomes. In this study, we develop a two-component therapeutic system from different parts of Glycyrrhiza: a functional hydrogel made from glycyrrhizic acid extracted from the stem and root, and nanosized chloroplast units (NCUs)…

  PublisherOA PDFDOI

Recent grants

• Harnessing Platelet-Endothelial Interactions for Exosome Delivery

  NIH · $3.8M · 2019–2027

• Developing Long Noncoding RNA Therapy for Precision Cardiac Repair

  NIH · $3.5M · 2019–2027

• Cardiac Patches Loaded with Stem Cell Factors to Treat Heart Failure

  NIH · $2.7M · 2019–2024

Frequent coauthors

• Shiqi Hu

  100 shared

• Junnan Tang

  Henan Provincial Center for Disease Control and Prevention

  81 shared

• Zhenhua Li

  Institute of Botany

  79 shared

• Ke Huang

  North Carolina State University

  74 shared

• Jhon Cores

  University of North Carolina at Chapel Hill

  62 shared

• Dashuai Zhu

  55 shared

• Teng Su

  50 shared

• Phuong‐Uyen Dinh

  North Carolina State University

  48 shared

Education

• Ph.D., Animal Science

  University of California, Davis

  2000

• M.S., Animal Science

  University of California, Davis

  1997

• B.S., Animal Science

  University of California, Davis

  1995

Similar researchers at North Carolina State University

• Matthew Breenh-77
• Mark Papichh-63
• Kenneth Adlerh-57