About

Nagashima Lab is located in the Department of Molecular & Cellular Biology at Harvard University. The research focuses on human immunology, microbiome, and diet.

Research topics

• Internal medicine
• Cardiology
• Medicine
• Artificial Intelligence
• Computer Science

Selected publications

• Different Determinants of the Recurrence of Atrial Fibrillation and Adverse Clinical Events in the Mid-Term Period After Atrial Fibrillation Ablation

  Circulation Journal · 2021 · 32 citations

  • Cardiology
  • Medicine
  • Internal medicine

  BACKGROUND: It is unclear whether there are differences in the clinical factors between atrial fibrillation (AF) recurrence and adverse clinical events (AEs), including stroke/transient ischemic attack (TIA), major bleeding, and death, after AF ablation. METHODS AND RESULTS: We examined the data from a retrospective multicenter Japanese registry conducted at 24 cardiovascular centers between 2011 and 2017. Of the 3,451 patients (74.1% men; 63.3±10.3 years) who underwent AF ablation, 1,046 (30.3%) had AF recurrence and 224 (6.5%) suffered AEs (51 strokes/TIAs, 71 major bleeding events, and 36 deaths) over a median follow-up of 20.7 months. After multivariate adjustment, female sex, persistent and long-lasting persistent AF (vs. paroxysmal AF), and stepwise increased left atrial diameter (LAd) quartiles were significantly associated with post-ablation recurrences. A multivariate analysis revealed that an age ≥75 years (vs. <65 years), body weight <50 kg, diabetes, vascular disease, left ventricular (LV) ejection fraction <40% (vs. ≥50%), Lad ≥44 mm (vs. <36 mm), and creatinine clearance <50 mL/min were independently associated with AE incidences, but not with recurrences. CONCLUSIONS: This study disclosed different determinants of post-ablation recurrence and AEs. Female sex, persistent AF, and enlarged LAd were determinants of post-ablation recurrence, whereas an old age, comorbidities, and LV and renal dysfunction rather than post-ablation recurrence were AEs determinants. These findings will help determine ablation indications and post-ablation management.

  DOI

• Novel Diagnostic Observations of Nodoventricular/Nodofascicular Pathway-Related Orthodromic Reciprocating Tachycardia Differentiating From Atrioventricular Nodal Re-Entrant Tachycardia

  JACC. Clinical electrophysiology · 2020 · 46 citations

  1st authorCorresponding
  • Computer Science
  • Cardiology
  • Medicine
  DOI

• Impact of the Fibrosis-4 Index on Risk Stratification of Cardiovascular Events and Mortality in Patients with Atrial Fibrillation: Findings from a Japanese Multicenter Registry

  Journal of Clinical Medicine · 2020 · 44 citations

  • Medicine
  • Internal medicine
  • Cardiology

  BACKGROUND: Liver diseases drive the development and progression of atrial fibrillation (AF). The Fibrosis-4 (FIB4) index is a non-invasive scoring method for detecting liver fibrosis, but the prognostic impact of using it for AF patients is still unknown. Herein, we evaluated using the FIB4 index as a risk assessment tool for cardiovascular events and mortality in patients with AF. METHODS: = 1023). RESULTS: < 0.001). CONCLUSIONS: The FIB4 index is independently associated with risks of cardiovascular events and all-cause mortality in AF patients.

  DOI

Frequent coauthors

• Yasuo Okumura

  Nihon University

  253 shared

• Toshiko Nakai

  Nihon University

  136 shared

• Kimie Ohkubo

  Nihon University

  122 shared

• Ichiro Watanabe

  122 shared

• Sayaka Kurokawa

  107 shared

• Yuji Wakamatsu

  Nihon University

  107 shared

• Ryuta Watanabe

  Nihon University

  106 shared

• Kazumasa Sonoda

  Tokyo Rinkai Hospital

  105 shared

Labs

• Nagashima LabPI

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