Edward Giovannucci

About

Edward Giovannucci is an Associate Professor in the Department of Medicine and a Professor of Nutrition and Epidemiology at Harvard T.H. Chan School of Public Health. He is affiliated with the Division of Nutrition at Harvard Medical School and is involved in research related to nutrition, epidemiology, and disease prevention. His work encompasses a broad range of topics including obesity, diabetes, cardiovascular health, cancer, microbiome, metabolism, and lifestyle medicine. Dr. Giovannucci's research focuses on understanding the role of nutrition and lifestyle factors in the development and prevention of chronic diseases, contributing to the advancement of clinical and public health strategies.

Research topics

• Internal medicine
• Medicine
• Oncology
• Biology
• Gastroenterology
• Physical therapy
• Gynecology
• Demography
• Genetics
• Physiology

Selected publications

• Global Burden of 5 Major Types of Gastrointestinal Cancer

  Gastroenterology · 2020 · 1936 citations

  DOI

• Physical activity and risks of breast and colorectal cancer: a Mendelian randomisation analysis

  Nature Communications · 2020 · 688 citations

  ) breast cancer and for colon cancer. Our results support a potentially causal relationship between higher physical activity levels and lower risks of breast cancer and colorectal cancer. Based on these data, the promotion of physical activity is probably an effective strategy in the primary prevention of these commonly diagnosed cancers.

  DOI

• Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction

  Nature Genetics · 2021 · 489 citations

  Prostate cancer is a highly heritable disease with large disparities in incidence rates across ancestry populations. We conducted a multiancestry meta-analysis of prostate cancer genome-wide association studies (107,247 cases and 127,006 controls) and identified 86 new genetic risk variants independently associated with prostate cancer risk, bringing the total to 269 known risk variants. The top genetic risk score (GRS) decile was associated with odds ratios that ranged from 5.06 (95% confidence…

  DOI

• Intermittent Fasting and Obesity-Related Health Outcomes

  JAMA Network Open · 2021 · 267 citations

  Importance: Several meta-analyses of randomized clinical trials (RCTs) have demonstrated the many health benefits of intermittent fasting (IF). However, there has been little synthesis of the strength and quality of this evidence in aggregate to date. Objective: To grade the evidence from published meta-analyses of RCTs that assessed the associations of IF (zero-calorie alternate-day fasting, modified alternate-day fasting, the 5:2 diet, and time-restricted eating) with obesity-related health ou…

  DOI

• Role of Diet in Colorectal Cancer Incidence

  JAMA Network Open · 2021 · 256 citations

  Importance: Several meta-analyses have summarized evidence for the association between dietary factors and the incidence of colorectal cancer (CRC). However, to date, there has been little synthesis of the strength, precision, and quality of this evidence in aggregate. Objective: To grade the evidence from published meta-analyses of prospective observational studies that assessed the association of dietary patterns, specific foods, food groups, beverages (including alcohol), macronutrients, and…

  DOI

Recent grants

• NIH Grant U19CA055075

  NIH · $16.9M · 2013

• NIH Grant R01CA133891

  NIH · $3.3M · 2015

• NIH Grant P01CA055075

  NIH · $73.6M · 2012

Frequent coauthors

• Charles S. Fuchs

  3402 shared

• Andrew T. Chan

  Brigham and Women's Hospital

  2933 shared

• Shuji Ogino

  Harvard University

  2448 shared

• Meir J. Stampfer

  The Technological College of Beer Sheva

  1788 shared

• Walter C. Willett

  Brigham and Women's Hospital

  1552 shared

• Kana Wu

  1289 shared

• Mingyang Song

  Massachusetts General Hospital

  1213 shared

• Jeffrey A. Meyerhardt

  1119 shared

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