JoAnn E Manson

About

JoAnn E Manson, MD, MPH, DrPH, is a Professor of Medicine and the Michael and Lee Bell Professor of Women’s Health at Harvard Medical School. She also serves as a Professor in the Department of Epidemiology at Harvard T.H. Chan School of Public Health and is the Chief of the Division of Preventive Medicine at Brigham and Women's Hospital. Dr. Manson is a physician epidemiologist and endocrinologist whose primary research interests include randomized clinical prevention trials of nutritional and lifestyle factors related to heart disease, diabetes, and other age-related disorders, as well as the role of endogenous and exogenous estrogens as determinants of chronic disease. She has contributed significantly to the field through her leadership in numerous research studies, including the Women’s Health Initiative Clinical Center in Boston, the cardiovascular component of the Nurses’ Health Study, the VITamin D and OmegA-3 TriaL (VITAL), the COcoa Supplement and Multivitamin Outcomes Study (COSMOS), and the VItamin D for COVID-19 (VIVID) trial. Dr. Manson has published more than 1,200 articles, authored or edited several books and textbooks, and serves as Editor-in-Chief of Contemporary Clinical Trials. She has received numerous honors, including awards from the American Heart Association, election to the Institute of Medicine of the National Academies, membership in the Association of American Physicians, and fellowship in AAAS. She is recognized as one of the most highly cited…

Research topics

• Medicine
• Internal medicine
• Biology
• Genetics
• Demography
• Environmental health
• Gerontology
• Physical therapy
• Cardiology
• Obstetrics

Selected publications

• Inherited causes of clonal haematopoiesis in 97,691 whole genomes

  Nature · 2020 · 726 citations

  DOI

• Association of Menopausal Hormone Therapy With Breast Cancer Incidence and Mortality During Long-term Follow-up of the Women’s Health Initiative Randomized Clinical Trials

  JAMA · 2020 · 407 citations

  Importance: The influence of menopausal hormone therapy on breast cancer remains unsettled with discordant findings from observational studies and randomized clinical trials. Objective: To assess the association of prior randomized use of estrogen plus progestin or prior randomized use of estrogen alone with breast cancer incidence and mortality in the Women's Health Initiative clinical trials. Design, Setting, and Participants: Long-term follow-up of 2 placebo-controlled randomized clinical tri…

  PublisherOA PDFDOI

• The Mediterranean diet, plasma metabolome, and cardiovascular disease risk

  European Heart Journal · 2020 · 356 citations

  Abstract Aims To investigate whether metabolic signature composed of multiple plasma metabolites can be used to characterize adherence and metabolic response to the Mediterranean diet and whether such a metabolic signature is associated with cardiovascular disease (CVD) risk. Methods and results Our primary study cohort included 1859 participants from the Spanish PREDIMED trial, and validation cohorts included 6868 participants from the US Nurses’ Health Studies I and II, and Health Professional…

  DOI

• Assessing the contribution of rare variants to complex trait heritability from whole-genome sequence data

  Nature Genetics · 2022 · 354 citations

  DOI

• Life expectancy associated with different ages at diagnosis of type 2 diabetes in high-income countries: 23 million person-years of observation

  The Lancet Diabetes & Endocrinology · 2023 · 202 citations

  BACKGROUND: The prevalence of type 2 diabetes is increasing rapidly, particularly among younger age groups. Estimates suggest that people with diabetes die, on average, 6 years earlier than people without diabetes. We aimed to provide reliable estimates of the associations between age at diagnosis of diabetes and all-cause mortality, cause-specific mortality, and reductions in life expectancy. METHODS: For this observational study, we conducted a combined analysis of individual-participant data…

  DOI

Recent grants

• NIH Grant N01WH032109

  NIH · $11.1M · 2005

• NIH Grant R01DK058845

  NIH · $7.8M · 2016

• NIH Grant R01DK046519

  NIH · $694k · 2000

Frequent coauthors

• Rowan T. Chlebowski

  IST Research

  7067 shared

• Garnet L. Anderson

  6275 shared

• Ross L. Prentice

  5558 shared

• Andrea Z. LaCroix

  University of California, San Diego

  5553 shared

• Mara Z. Vitolins

  Wake Forest University

  5541 shared

• Lewis H. Kuller

  University of Pittsburgh

  5538 shared

• Sylvia Wassertheil‐Smoller

  5531 shared

• Judith Hsia

  University of Colorado Anschutz Medical Campus

  5351 shared

Education

• Ph.D., Nutrition

  Harvard University

  1980

• M.S., Nutrition

  University of Massachusetts

  1976

• B.S., Nutrition

  University of Massachusetts

  1973

Awards & honors

• American Heart Association’s (AHA) Population Research Prize
• AHA’s Distinguished Scientist Award
• AHA’s Research Achievement Award
• election to the Institute of Medicine of the National Academ…
• membership in the Association of American Physicians (AAP)

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• Edward Giovannuccih-267
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