Genetic drivers of heterogeneity in type 2 diabetes pathophysiology

Nature · 2024 · 480 citations

• Biology
• Genetics
• Evolutionary biology

in a further 279,552 individuals of diverse ancestry, including 30,288 cases of T2D, and test their association with T2D-related vascular outcomes. Cluster-specific partitioned polygenic scores are associated with coronary artery disease, peripheral artery disease and end-stage diabetic nephropathy across ancestry groups, highlighting the importance of obesity-related processes in the development of vascular outcomes. Our findings show the value of integrating multi-ancestry genome-wide association study data with single-cell epigenomics to disentangle the aetiological heterogeneity that drives the development and progression of T2D. This might offer a route to optimize global access to genetically informed diabetes care.

A multiancestry genome-wide association study of unexplained chronic ALT elevation as a proxy for nonalcoholic fatty liver disease with histological and radiological validation

Nature Genetics · 2022 · 188 citations

• Biology
• Internal medicine
• Genetics

Large-scale genome-wide association study of coronary artery disease in genetically diverse populations

Nature Medicine · 2022 · 338 citations

• Biology
• Genetics
• Bioinformatics

Discovery of 318 new risk loci for type 2 diabetes and related vascular outcomes among 1.4 million participants in a multi-ancestry meta-analysis

Nature Genetics · 2020 · 787 citations

• Biology
• Genetics
• Bioinformatics