Junhyong Kim

About

Professor Junhyong Kim is the Chair and Patricia M. Williams Professor in the Department of Biology at the University of Pennsylvania. He is also the Co-Director of the Penn Program in Single Cell Biology. His research focuses on the evolutionary and molecular biology of the cell, contributing to understanding cellular processes at a molecular level. Dr. Kim's laboratory is located in Lynch Laboratory, where he leads a team that includes senior scientists, research staff, postdoctoral fellows, graduate students, visiting scholars, and affiliates. His work involves both wet lab and dry lab spaces, supporting a broad range of research activities in cellular and molecular biology.

Research topics

• Computational biology
• Biology
• Cell biology
• Bioinformatics
• Data Mining
• Computer Science
• Genetics
• Artificial Intelligence
• Data science
• Anatomy

Selected publications

• The Human Tumor Atlas Network: Charting Tumor Transitions across Space and Time at Single-Cell Resolution

  Cell · 2020 · 581 citations

  Crucial transitions in cancer-including tumor initiation, local expansion, metastasis, and therapeutic resistance-involve complex interactions between cells within the dynamic tumor ecosystem. Transformative single-cell genomics technologies and spatial multiplex in situ methods now provide an opportunity to interrogate this complexity at unprecedented resolution. The Human Tumor Atlas Network (HTAN), part of the National Cancer Institute (NCI) Cancer Moonshot Initiative, will establish a clinic…

  DOI

• Multi-omics integration in the age of million single-cell data

  Nature Reviews Nephrology · 2021 · 255 citations

  Senior authorCorresponding
  DOI

• Single cell regulatory landscape of the mouse kidney highlights cellular differentiation programs and disease targets

  Nature Communications · 2021 · 220 citations

  Determining the epigenetic program that generates unique cell types in the kidney is critical for understanding cell-type heterogeneity during tissue homeostasis and injury response. Here, we profile open chromatin and gene expression in developing and adult mouse kidneys at single cell resolution. We show critical reliance of gene expression on distal regulatory elements (enhancers). We reveal key cell type-specific transcription factors and major gene-regulatory circuits for kidney cells. Dyna…

  DOI

• Advances and prospects for the Human BioMolecular Atlas Program (HuBMAP)

  Nature Cell Biology · 2023 · 170 citations

  PublisherOA PDFDOI

• Tumour-derived small extracellular vesicles act as a barrier to therapeutic nanoparticle delivery

  Nature Materials · 2024-09-02 · 53 citations

  articleOpen access
  PublisherOA PDFDOI

Recent grants

• AToL: Collaborative Research: A Phylogenomic Toolbox for Assembling the Tree of Life

  NSF · $538k · 2003–2009

• NIH Grant U01MH09895304

  NIH · $2.3M · 2016

• Center for Sub-Cellular Genomics

  NIH · $9.0M · 2018–2024

Frequent coauthors

• James Eberwine

  University of Pennsylvania

  57 shared

• Stephen Fisher

  38 shared

• Hannah Dueck

  National Cancer Institute

  28 shared

• Jennifer Spaethling

  Translational Therapeutics (United States)

  21 shared

• Robert R. Sokal

  20 shared

• David Issadore

  University of Pennsylvania

  20 shared

• Jai‐Yoon Sul

  Translational Therapeutics (United States)

  19 shared

• Young-Ji Na

  19 shared

Labs

• Kim LabPI

  Evolutionary and Molecular Biology of the Cell

Education

• Ph.D., Biology

  University of California, San Diego

  2000

• B.S., Biology

  University of California, San Diego

  1995

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