Jun (Jay) Zhu

About

Jun (Jay) Zhu, Ph.D., is a Professor of Microbiology at the University of Pennsylvania's Perelman School of Medicine. His research focuses on bacterial pathogenesis, particularly how pathogenic bacteria sense and respond to their environment. His laboratory studies Vibrio cholerae, the causative agent of cholera, to understand the chemical signals it receives during infection and how these signals influence gene expression and virulence. Zhu's work has identified host-produced small molecules that trigger virulence programs in V. cholerae and has explored the role of quorum sensing in regulating virulence and biofilm formation. Additionally, his research investigates how V. cholerae responds to oxidative and nitrosative stresses during infection. His team employs genetic screens, biochemical techniques, animal models, and deep sequencing to probe these mechanisms. Zhu has also extended his expertise to study Clostridium difficile, aiming to shed light on its pathogenesis and identify potential treatment strategies. His contributions advance understanding of host-pathogen interactions and bacterial adaptation during infection.

Research topics

• Medicine
• Nursing
• Environmental health
• Internal medicine
• Finance
• Business
• Physical therapy
• Family medicine
• Economics
• Marketing

Selected publications

• Spending and quality after three years of Medicare’s bundled payments for medical conditions: quasi-experimental difference-in-differences study

  BMJ · 2020 · 45 citations

  OBJECTIVE: To evaluate whether longer term participation in the bundled payments for care initiative (BPCI) for medical conditions in the United States, which held hospitals financially accountable for all spending during an episode of care from hospital admission to 90 days after discharge, was associated with changes in spending, mortality, or health service use. DESIGN: Quasi-experimental difference-in-differences analysis. SETTING: US hospitals participating in bundled payments for acute myo…

  DOI

• Effect of Gamification, Financial Incentives, or Both to Increase Physical Activity Among Patients at High Risk of Cardiovascular Events: The BE ACTIVE Randomized Controlled Trial

  Circulation · 2024-04-07 · 39 citations

  articleOpen access

  BACKGROUND: Physical activity is associated with a lower risk of major adverse cardiovascular events, but few individuals achieve guideline-recommended levels of physical activity. Strategies informed by behavioral economics increase physical activity, but their longer-term effectiveness is uncertain. We sought to determine the effect of behaviorally designed gamification, loss-framed financial incentives, or their combination on physical activity compared with attention control over 12-month in…

  PublisherOA PDFDOI

• Effect of Patient Financial Incentives on Statin Adherence and Lipid Control

  JAMA Network Open · 2020 · 35 citations

  Importance: Financial incentives can improve medication adherence and cardiovascular disease risk, but the optimal design to promote sustained adherence after incentives are discontinued is unknown. Objective: To determine whether 6-month interventions involving different financial incentives to encourage statin adherence reduce low-density lipoprotein cholesterol (LDL-C) levels from baseline to 12 months. Design, Setting, and Participants: This 4-group, randomized clinical trial was conducted f…

  PublisherOA PDFDOI

• Qualitative Exploration of Barriers to Statin Adherence and Lipid Control

  JAMA Network Open · 2021 · 22 citations

  Importance: Financial incentives may improve health by rewarding patients for focusing on present actions-such as medication regimen adherence-that provide longer-term health benefits. Objective: To identify barriers to improving statin therapy adherence and control of cholesterol levels with financial incentives and insights for the design of future interventions. Design, Setting, and Participants: This qualitative study involved retrospective interviews with participants in a preplanned second…

  PublisherOA PDFDOI

• A randomized controlled trial of gamification, financial incentives, or both to increase physical activity among patients with elevated risk for cardiovascular disease: rationale and design of the be active study

  American Heart Journal · 2023-03-02 · 21 citations

  articleOpen access
  PublisherOA PDFDOI

Frequent coauthors

• Kevin G. Volpp

  University of Pennsylvania

  260 shared

• David A. Asch

  95 shared

• Judy A. Shea

  92 shared

• Amol S. Navathe

  University of Pennsylvania

  72 shared

• Robert Galvin

  69 shared

• Annice Kim

  Southern Federal University

  66 shared

• Jeanette M. Renaud

  Laboratoire Dr Renaud

  64 shared

• Angela Towers

  Manchester Metropolitan University

  64 shared

Education

• B.S., Microbiology

  Wuhan University

  1991

• Ph.D., Microbiology

  Cornell University

  1999

Similar researchers at University of Pennsylvania

• John Q. Trojanowskih-296
• Craig B. Thompsonh-277
• Daniel J Raderh-236