Jonathan Drake

About

Jonathan Drake is an Assistant Professor of Neurology and a Clinician Educator at Brown University. He holds a medical degree from New York Medical College obtained in 2013, a Master of Science from the University of Massachusetts, Boston, earned in 2009, a Master of Arts from Boston University School of Medicine in 2007, and a Bachelor of Science from the University of Massachusetts, Amherst, completed in 1993. His professional role involves both clinical practice and educational responsibilities within the Department of Neurology at Brown University.

Research topics

• Medicine
• Internal medicine
• Psychology
• Oncology
• Neuroscience

Selected publications

• Peripheral Markers of Vascular Endothelial Dysfunction Show Independent but Additive Relationships with Brain-Based Biomarkers in Association with Functional Impairment in Alzheimer’s Disease

  Journal of Alzheimer s Disease · 2021-03-12 · 41 citations

  articleOpen access1st authorCorresponding

  BACKGROUND: Cerebrovascular dysfunction confers risk for functional decline in Alzheimer's disease (AD), yet the clinical interplay of these two pathogenic processes is not well understood. OBJECTIVE: We utilized Alzheimer's Disease Neuroimaging Initiative (ADNI) data to examine associations between peripherally derived soluble cell adhesion molecules (CAMs) and clinical diagnostic indicators of AD. METHODS: Using generalized linear regression models, we examined cross-sectional relationships of…

  PublisherOA PDFDOI

• Novel blood test for early biomarkers of preeclampsia and Alzheimer’s disease

  Scientific Reports · 2021-08-05 · 40 citations

  articleOpen access

  A non-invasive and sensitive blood test has long been a goal for early stage disease diagnosis and treatment for Alzheimer's disease (AD) and other proteinopathy diseases. We previously reported that preeclampsia (PE), a severe pregnancy complication, is another proteinopathy disorder with impaired autophagy. We hypothesized that induced autophagy deficiency would promote accumulation of pathologic protein aggregates. Here, we describe a novel, sensitive assay that detects serum protein aggregat…

  PublisherOA PDFDOI

• A blood biomarker test for brain amyloid impacts the clinical evaluation of cognitive impairment

  Annals of Clinical and Translational Neurology · 2023-08-07 · 33 citations

  articleOpen access

  OBJECTIVE: The objective of this study was to examine clinicians' patient selection and result interpretation of a clinically validated mass spectrometry test measuring amyloid beta and ApoE blood biomarkers combined with patient age (PrecivityAD® blood test) in symptomatic patients evaluated for Alzheimer's disease (AD) or other causes of cognitive decline. METHODS: The Quality Improvement and Clinical Utility PrecivityAD Clinician Survey (QUIP I, ClinicalTrials.gov Identifier: NCT05477056) was…

  PublisherOA PDFDOI

• Common biomarkers of physiologic stress and associations with delirium in patients with intracerebral hemorrhage

  Journal of Critical Care · 2021-03-23 · 21 citations

  articleOpen access
  PublisherOA PDFDOI

• A Pilot Study of the Fluctuating Mental Status Evaluation: A Novel Delirium Screening Tool for Neurocritical Care Patients

  Neurocritical Care · 2022-10-14 · 13 citations

  articleOpen access
  PublisherOA PDFDOI

Frequent coauthors

• Brian R. Ott

  Brown University

  123 shared

• Lori A. Daiello

  Brown University

  121 shared

• Akiva Mintz

  109 shared

• Bryan M. Spann

  San Francisco VA Medical Center

  105 shared

• Marwan N. Sabbagh

  98 shared

• Andrew J. Saykin

  Indiana University

  95 shared

• Kwangsik Nho

  Indiana University School of Medicine

  83 shared

• John C. Morris

  Washington University in St. Louis

  78 shared

Education

• M.D.

  New York Medical College

  2013

• M.S.

  University of Massachusetts, Boston

  2009

• M.A.

  Boston University School of Medicine

  2007

• B.S.

  University of Massachusetts, Amherst

  1993

Similar researchers at Brown University

• Karen Furieh-148
• Rena Wingh-146
• Lawrence Priceh-132