Jashvant Unadkat

About

Jashvant (Jash) Unadkat, Ph.D., is a Professor of Pharmaceutics at the School of Pharmacy, University of Washington, Seattle. He received his Bachelor of Pharmacy from the University of London in 1977, his Ph.D. from the University of Manchester in 1982, and completed postdoctoral training at the University of California at San Francisco from 1982 to 1985. Dr. Unadkat studies the mechanisms of transport and metabolism of drugs, including during pregnancy, with a focus on blood-brain and blood-CSF barriers, central nervous system, drug transporters, pharmacokinetics-pharmacodynamics, and maternal-fetal pharmacology. He has published more than 270 peer-reviewed research papers and is a fellow of AAAS, AAPS, and JSSX. He is the founding co-chair of the focus group of AAPS on Drug Transport and Uptake and has received notable awards such as the AAPS Research Achievement Award in 2012 and the ISSX Research Achievement Award in 2023. Dr. Unadkat created and led the UW Research Affiliates Program on Transporters (UWRAPT) for ten years and currently co-leads the UW Transporter Elucidation Center, funded by NICHD, to identify and characterize novel transporters in the placenta and developing intestine. His research emphasizes mechanisms of drug transport and metabolism, including maternal-fetal pharmacology.

Research topics

• Pharmacology
• Chemistry
• Biology
• Stereochemistry
• Intensive care medicine
• Medicine
• Biochemistry

Selected publications

• Applications, Challenges, and Outlook for PBPK Modeling and Simulation: A Regulatory, Industrial and Academic Perspective

  Pharmaceutical Research · 2022 · 133 citations

  DOI

• Predicting the Potential for Cannabinoids to Precipitate Pharmacokinetic Drug Interactions via Reversible Inhibition or Inactivation of Major Cytochromes P450

  Drug Metabolism and Disposition · 2020 · 85 citations

  Senior authorCorresponding
  DOI

• Dysregulation of Human Hepatic Drug Transporters by Proinflammatory Cytokines

  Journal of Pharmacology and Experimental Therapeutics · 2024-08-05 · 15 citations

  articleOpen accessSenior author
  PublisherOA PDFDOI

• The effect of pregnancy-related hormones on hepatic transporters: studies with premenopausal human hepatocytes

  Frontiers in Pharmacology · 2024-08-07 · 8 citations

  articleOpen accessSenior author

  Introduction Pregnancy results in significant changes in drug pharmacokinetics (PK). While previous studies have elucidated the impact of pregnancy-related hormones (PRH) on mRNA or protein expression and activity of major hepatic metabolizing enzymes, their effect on hepatic drug transporters remains largely unexplored. Therefore, we investigated the effect of a cocktail of PRH on the mRNA expression and activity of hepatic transporters. Methods Plated human hepatocytes (PHH) from 3 premenopaus…

  PublisherOA PDFDOI

• Quantification and prediction of human fetal (-)-Δ9-tetrahydrocannabinol/(±)-11-OH-Δ9-tetrahydrocannabinol exposure during pregnancy to inform fetal cannabis toxicity

  Nature Communications · 2025-01-18 · 7 citations

  articleOpen accessSenior author

  Prenatal cannabis use is associated with neurodevelopmental deficits, likely due to exposure to the psychoactive cannabinoid, (-)-Δ9-tetrahydrocannabinol, and its active metabolite, (±)-11-OH-Δ9-tetrahydrocannabinol. To determine causality, preclinical studies mimicking human fetal cannabinoid exposure must be conducted. Here we show cannabinoid concentrations across gestation in maternal plasma and paired fetal tissues in trimester 1 and 2 and maternal plasma and fetal umbilical venous plasma i…

  PublisherOA PDFDOI

Recent grants

• A Systems Pharmacology approach to predict the effects of pregnancy and infectious diseases on transporter-mediated drug disposition

  NIH · $2.1M · 2021–2027

• NIH Grant RC1NS068904

  NIH · $1000k · 2012

• NIH Grant R33AG031485

  NIH · $950k · 2013

Frequent coauthors

• Cornelis E. C. A. Hop

  345 shared

• Laurent Salphati

  330 shared

• Yurong Lai

  Gilead Sciences (United States)

  311 shared

• Xiaoyan Chu

  Merck & Co., Inc., Rahway, NJ, USA (United States)

  287 shared

• Bhagwat Prasad

  Washington State University Spokane

  277 shared

• Guangqing Xiao

  Traditional Chinese Medicine Hospital of Kunshan

  230 shared

• Anita Mathias

  228 shared

• Mingxiang Liao

  Jazz Pharmaceuticals (United States)

  227 shared

Labs

• Plein Center for AgingPI

Education

• Ph.D.

  University of Manchester

• Other

  University of London

Awards & honors

• AAPS Research Achievement Award (2012)
• ISSX Research Achievement Award (2023)

Similar researchers at University of Washington

• Rodney JY Hoh-43
• Yvonne Linh-37
• Samuel Arnoldh-23