Yvonne Lin

· Assistant Dean for Academic Affairs; Associate Professor

University of Washington · Pharmacology

Active 1997–2026

h-index37

Citations6.3k

Papers8918 last 5y

Funding$6.6M

Academic metrics are sourced from OpenAlex and public funding records; values may differ from Google Scholar.

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About

Dr. Yvonne Lin is an Assistant Dean for Academic Affairs and an Associate Professor in the Department of Pharmaceutics at the University of Washington School of Pharmacy. She holds a BA in Biophysics from the University of California at Berkeley and a PhD in Pharmaceutical Sciences from the University of Washington. Her research interests include natural product-drug interactions, regulation of drug metabolizing enzymes in children and pregnant women, and the use of metabolomics to discover endogenous biomarkers of drug metabolism and transport. Dr. Lin completed a postdoctoral fellowship at St. Jude Children’s Research Hospital. She is actively involved in teaching courses such as PHARBE 506, PHARBE 510, PCEUT 507, and PCEUT 537, and accepts students into her lab for research.

Research topics

Internal medicine
Biochemistry
Medicine
Urology
Computational biology
Bioinformatics
Genetics
Endocrinology
Chemistry
Environmental chemistry

Selected publications

Differences in 25-Hydroxyvitamin D Clearance by eGFR and Race: A Pharmacokinetic Study
Journal of the American Society of Nephrology · 2020 · 24 citations
BACKGROUND: Conversion of 25-hydroxyvitamin D (25[OH]D) to the active form of vitamin D occurs primarily in the kidney. Observational studies suggest 25(OH)D clearance from the circulation differs by kidney function and race. However, these potential variations have not been tested using gold-standard methods. METHODS: supplementation. RESULTS: supplementation did not differ. CONCLUSIONS: Using direct pharmacokinetic measurements, we show that 25(OH)D clearance is reduced in CKD and may differ b…
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Development and Application of a Multidimensional Database for the Detection of Quaternary Ammonium Compounds and Their Phase I Hepatic Metabolites in Humans
Environmental Science & Technology · 2024 · 21 citations
), and MS/MS spectra for 19 parent QACs and 81 QAC metabolites. Using this database, we confidently identified 13 parent QACs and 35 metabolites in de-identified human fecal samples. This is the first study to integrate in vitro metabolite biosynthesis with LC-IM-MS/MS for the simultaneous monitoring of parent QACs and their metabolites in humans.
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Sources of Interindividual Variability
Methods in molecular biology · 2021 · 16 citations
1st authorCorresponding
Publisher DOI
The Impact of Proximal Roux‐en‐Y Gastric Bypass Surgery on Acetaminophen Absorption and Metabolism
Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy · 2020-01-21 · 15 citations
articleSenior authorCorresponding
BACKGROUND: Roux-en-Y gastric bypass (RYGBS), a surgery that creates a smaller stomach pouch and reduces the length of small intestine, is one of the most common medical interventions for the treatment of obesity. AIM: The aim of this study was to determine how RYGBS affects the absorption and metabolism of acetaminophen. MATERIALS AND METHODS: Ten morbidly obese patients received 1.5 g of liquid acetaminophen (APAP) orally on three separate pharmacokinetic study days (i.e., pre-RYGBS baseline a…
Publisher DOI
Validation of the 24,25-dihydroxyvitamin D3 to 25-hydroxyvitamin D3 ratio as a biomarker of 25-hydroxyvitamin D3 clearance
The Journal of Steroid Biochemistry and Molecular Biology · 2021-12-22 · 14 citations
articleOpen access
Publisher OA PDF DOI

Recent grants

NIH Grant R01HD058556
NIH · $2.7M · 2016
Building Research across Interdisciplinary Gaps (BRIDG) T90/R90 Training Program
NIH · $3.9M · 2015–2025

Frequent coauthors

Kenneth E. Thummel
University of Washington
43 shared
Erin G. Schuetz
28 shared
Mary F. Paine
Washington State University Spokane
25 shared
Scott J. Brantley
16 shared
Swati Nagar
Temple University
16 shared
Aneesh A. Argikar
Syneos Health (United States)
16 shared
Jatinder K. Lamba
Florida College
15 shared
Danny D. Shen
University of Washington
15 shared

Education

B.A., Biophysics
University of California at Berkeley
Ph.D., Pharmaceutical Sciences
University of Washington

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