Jack Odle

About

Dr. Jack Odle has spent his career in agri-medical research, exploring nutritional and metabolic interventions to improve the health of domestic animals and humans. He has worked over 30 years to develop and utilize the young pig as a pediatric nutrition and metabolism model. The piglet research model developed in his laboratories is considered the premier model for pediatric pre-clinical research. His basic science research on piglets can apply broadly to all mammalian neonates. Specific elements of his research have investigated the developmental regulation of lipid metabolism and nutritional variables impacting the intestinal health of the neonate. He serves as Editor-in-chief of the journal Current Developments in Nutrition, published by the American Society for Nutrition.

Research topics

• Biology
• Medicine
• Internal medicine
• Microbiology
• Biochemistry
• Immunology
• Cell biology
• Genetics
• Chemistry
• Physiology

Selected publications

• Probiotics, Prebiotics and Epithelial Tight Junctions: A Promising Approach to Modulate Intestinal Barrier Function

  International Journal of Molecular Sciences · 2021 · 220 citations

  Disruptions in the intestinal epithelial barrier can result in devastating consequences and a multitude of disease syndromes, particularly among preterm neonates. The association between barrier dysfunction and intestinal dysbiosis suggests that the intestinal barrier function is interactive with specific gut commensals and pathogenic microbes. In vitro and in vivo studies demonstrate that probiotic supplementation promotes significant upregulation and relocalization of interepithelial tight jun…

  PublisherOA PDFDOI

• The health benefits of selenium in food animals: a review

  Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology · 2022 · 109 citations

  Selenium is an essential trace mineral important for the maintenance of homeostasis in animals and humans. It evinces a strong antioxidant, anti-inflammatory and potential antimicrobial capacity. Selenium biological function is primarily achieved by its presence in selenoproteins as a form of selenocysteine. Selenium deficiency may result in an array of health disorders, affecting many organs and systems; to prevent this, dietary supplementation, mainly in the forms of organic (i.e., selenomethi…

  PublisherOA PDFDOI

• Gut microbiome contributions to altered metabolism in a pig model of undernutrition

  Proceedings of the National Academy of Sciences · 2021 · 29 citations

  The concept that gut microbiome-expressed functions regulate ponderal growth has important implications for infant and child health, as well as animal health. Using an intergenerational pig model of diet restriction (DR) that produces reduced weight gain, we developed a feature-selection algorithm to identify representative characteristics distinguishing DR fecal microbiomes from those of full-fed (FF) pigs as both groups consumed a common sequence of diets during their growth cycle. Gnotobiotic…

  DOI

• Dietary Zn proteinate with moderate chelation strength alleviates heat stress-induced intestinal barrier function damage by promoting expression of tight junction proteins via the A20/NF-κB p65/MMP-2 pathway in the jejunum of broilers

  Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology · 2024-09-01 · 15 citations

  articleOpen access

  BACKGROUND: The aim of this study was to determine whether and how Zn proteinate with moderate chelation strength (Zn-Prot M) can alleviate heat stress (HS)-induced intestinal barrier function damage of broilers. A completely randomized design was used for comparatively testing the effects of Zn proteinate on HS and non-HS broilers. Under high temperature (HT), a 1 (Control, HT-CON) + 2 (Zn source) × 2 (added Zn level) factorial arrangement of treatments was used. The 2 added Zn sources were Zn-…

  PublisherOA PDFDOI

• Gruel Creep Feeding Accelerates Growth and Alters Intestinal Health of Young Pigs

  Animals · 2022 · 13 citations

  Senior authorCorresponding

  To combat the stress of weaning, we utilized novel gruel creep feeders to supplement suckling pigs with divergent soluble (n = 6 litters) versus insoluble (n = 6) diets compared with un-supplemented controls (n = 6). Post-weaning, pigs were fed a common phase 1 diet. Average daily weight gains of pigs fed soluble and insoluble creep diets were 53% and 17% greater than control pigs, respectively (p < 0.01). Creep intake was higher (82%) for pigs fed the soluble diet, and the accompanying weight i…

  PublisherOA PDFDOI

Recent grants

• Post-natal development of enteric glial cell-epithelial interactions in repair of ischemic-injured intestine

  NIH · $1.8M · 2019–2025

Frequent coauthors

• Xi Lin

  108 shared

• Sheila K. Jacobi

  The Ohio State University

  40 shared

• Anthony T. Blikslager

  North Carolina State University

  35 shared

• R. T. Zijlstra

  University of Alberta

  25 shared

• R. J. Harrell

  Institute for Bioscience and Biotechnology Research

  23 shared

• Amanda L. Ziegler

  North Carolina State University

  23 shared

• Yongwen Zhu

  South China Agricultural University

  21 shared

• Sharon M. Donovan

  University of Illinois Urbana-Champaign

  20 shared

Education

• PhD, Nutrition

  University of Wisconsin Madison

  1989

• MS, Meat and Animal Science

  University of Wisconsin Madison

  1985

• BS, Animal Science

  Purdue University

  1982

Awards & honors

• William Neal Reynolds Distinguished Professor

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