Anthony Blikslager

About

Anthony Blikslager is a faculty member at the College of Veterinary Medicine at NC State University. The page text does not provide specific details about his research focus, background, or key contributions. Therefore, no detailed biography information is available from the provided content.

Research topics

• Internal medicine
• Medicine
• Biology
• Cell biology
• Sociology
• Immunology
• Surgery
• Chemistry
• Biochemistry
• Gastroenterology

Selected publications

• The Integral Role of Tight Junction Proteins in the Repair of Injured Intestinal Epithelium

  International Journal of Molecular Sciences · 2020 · 233 citations

  Senior authorCorresponding

  The intestinal epithelial monolayer forms a transcellular and paracellular barrier that separates luminal contents from the interstitium. The paracellular barrier consists of a highly organized complex of intercellular junctions that is primarily regulated by apical tight junction proteins and tight junction-associated proteins. This homeostatic barrier can be lost through a multitude of injurious events that cause the disruption of the tight junction complex. Acute repair after injury leading t…

  DOI

• Probiotics, Prebiotics and Epithelial Tight Junctions: A Promising Approach to Modulate Intestinal Barrier Function

  International Journal of Molecular Sciences · 2021 · 220 citations

  Disruptions in the intestinal epithelial barrier can result in devastating consequences and a multitude of disease syndromes, particularly among preterm neonates. The association between barrier dysfunction and intestinal dysbiosis suggests that the intestinal barrier function is interactive with specific gut commensals and pathogenic microbes. In vitro and in vivo studies demonstrate that probiotic supplementation promotes significant upregulation and relocalization of interepithelial tight jun…

  PublisherOA PDFDOI

• The Regulation of Intestinal Mucosal Barrier by Myosin Light Chain Kinase/Rho Kinases

  International Journal of Molecular Sciences · 2020 · 128 citations

  Senior authorCorresponding

  The intestinal epithelial apical junctional complex, which includes tight and adherens junctions, contributes to the intestinal barrier function via their role in regulating paracellular permeability. Myosin light chain II (MLC-2), has been shown to be a critical regulatory protein in altering paracellular permeability during gastrointestinal disorders. Previous studies have demonstrated that phosphorylation of MLC-2 is a biochemical marker for perijunctional actomyosin ring contraction, which i…

  PublisherOA PDFDOI

• Porcine Models of the Intestinal Microbiota: The Translational Key to Understanding How Gut Commensals Contribute to Gastrointestinal Disease

  Frontiers in Veterinary Science · 2022 · 49 citations

  In the United States, gastrointestinal disorders account for in excess of $130 billion in healthcare expenditures and 22 million hospitalizations annually. Many of these disorders, including necrotizing enterocolitis of infants, obesity, diarrhea, and inflammatory bowel disease, are associated with disturbances in the gastrointestinal microbial composition and metabolic activity. To further elucidate the pathogenesis of these disease syndromes as well as uncover novel therapies and preventative…

  PublisherOA PDFDOI

• Non‐steroidal anti‐inflammatory drugs in equine orthopaedics

  Equine Veterinary Journal · 2022 · 18 citations

  Senior authorCorresponding

  Orthopaedic disorders are commonly encountered in equine veterinary medicine, and non-steroidal anti-inflammatory drugs (NSAIDs) play an important role in the management of many equine orthopaedic disorders. There are multiple NSAIDs available for use in horses, including both non-selective and selective NSAIDS, and the body of literature evaluating the efficacy of these medications, their effects on normal and inflamed musculoskeletal tissues, and their side effects is broad. This review aims t…

  PublisherOA PDFDOI

Recent grants

• NIH Grant R29DK053284

  NIH · $515k · 2003

• Pilot and Feasibility Program

  NIH · $11.4M · 1996–2030

• NIH Grant F32DK009400

  NIH · $105k

Frequent coauthors

• Amanda L. Ziegler

  North Carolina State University

  48 shared

• Robert A. Argenzio

  University of California, Davis

  41 shared

• Dianne Little

  Purdue University West Lafayette

  37 shared

• Callie Fogle

  North Carolina State University

  36 shared

• Jack Odle

  North Carolina State University

  35 shared

• Liara M. Gonzalez

  North Carolina State University

  34 shared

• Mathew P. Gerard

  North Carolina State University

  34 shared

• Alison J. Morton

  33 shared

Labs

• K9/Feline Oncology Diagnostic LabPI

Education

• Ph.D., Comparative Medicine

  North Carolina State University

  2003

• M.S., Comparative Medicine

  North Carolina State University

  1999

• B.S., Animal Science

  University of Georgia

  1997

Awards & honors

• AVMA Clinical Research Award (2020)
• Alumni Distinguished Professor
• Ned E. Huffman Leadership Award from NC State University (20…
• Applied Equine Research Award from the World Equestrian Vete…
• Pfizer Award for Excellence in Research from NC State Univer…

Similar researchers at North Carolina State University

• Edward Breitschwerdth-100
• B. Duncan X. Lascellesh-67
• Craig Harmsh-54