Felipe Carvalho da Silva

About

Felipe Carvalho da Silva is an Assistant Professor and Extension Beef Specialist at North Carolina State University within the College of Agriculture and Life Sciences, Department of Animal Science. His long-term research goal is to improve reproductive efficiency in cattle operations by studying fetal-maternal interactions during early gestation, aiming to decrease early pregnancy loss, conserve natural resources, and enhance the economic viability of the US cattle industry. His current research focuses on the effects of dietary fatty acids and choline on embryonic elongation and maternal recognition of pregnancy. In addition to his research, he provides extension support to beef producers and extension personnel in North Carolina regarding reproductive management in beef operations. Dr. Silva holds a Ph.D. in Reproductive Biology from the University of Florida, an M.S. in Reproductive Physiology from North Dakota State University, and a B.Vet.Med in Veterinary Medicine from Sao Paulo State University – Jaboticabal. His areas of expertise include uterine biology, pregnancy, reproductive physiology, and beef cattle production.

Research topics

• Artificial Intelligence
• Computer Science
• Biology
• Biochemical engineering
• Genetics
• Physics
• Engineering
• Medicine
• Virology
• Computational biology

Selected publications

• On the interactions of the receptor-binding domain of SARS-CoV-1 and SARS-CoV-2 spike proteins with monoclonal antibodies and the receptor ACE2

  Virus Research · 2020 · 61 citations

  Senior authorCorresponding
  DOI

• Both Charge-Regulation and Charge-Patch Distribution Can Drive Adsorption on the Wrong Side of the Isoelectric Point

  Journal of the American Chemical Society · 2022-01-20 · 57 citations

  article

  The mechanism of protein-polyelectrolyte complexation on the wrong side of the isoelectric point has long puzzled researchers. Two alternative explanations have been proposed in the literature: (a) the charge-patch (CP) mechanism, based on the inhomogeneous distribution of charges on the protein, and (b) the charge-regulation (CR) mechanism, based on the variable charge of weak acid and base groups, which may invert the protein charge in the presence of another highly charged object. To discern…

  PublisherDOI

• Electrostatic Features for the Receptor Binding Domain of SARS-COV-2 Wildtype and Its Variants. Compass to the Severity of the Future Variants with the Charge-Rule

  The Journal of Physical Chemistry B · 2022-09-06 · 37 citations

  article1st authorCorresponding

  Electrostatic intermolecular interactions are important in many aspects of biology. We have studied the main electrostatic features involved in the interaction of the receptor-binding domain (RBD) of the SARS-CoV-2 spike protein with the human receptor Angiotensin-converting enzyme 2 (ACE2). As the principal computational tool, we have used the FORTE approach, capable to model proton fluctuations and computing free energies for a very large number of protein–protein systems under different physi…

  PublisherDOI

• VLP-Based COVID-19 Vaccines: An Adaptable Technology against the Threat of New Variants

  Vaccines · 2021-11-30 · 37 citations

  reviewOpen access

  Virus-like particles (VLPs) are a versatile, safe, and highly immunogenic vaccine platform. Recently, there are developmental vaccines targeting SARS-CoV-2, the causative agent of COVID-19. The COVID-19 pandemic affected humanity worldwide, bringing out incomputable human and financial losses. The race for better, more efficacious vaccines is happening almost simultaneously as the virus increasingly produces variants of concern (VOCs). The VOCs Alpha, Beta, Gamma, and Delta share common mutation…

  PublisherOA PDFDOI

• Up State of the SARS-COV-2 Spike Homotrimer Favors an Increased Virulence for New Variants

  Frontiers in Medical Technology · 2021-06-30 · 28 citations

  articleOpen accessSenior authorCorresponding

  The COVID-19 pandemic has spread worldwide. However, as soon as the first vaccines-the only scientifically verified and efficient therapeutic option thus far-were released, mutations combined into variants of SARS-CoV-2 that are more transmissible and virulent emerged, raising doubts about their efficiency. This study aims to explain possible molecular mechanisms responsible for the increased transmissibility and the increased rate of hospitalizations related to the new variants. A combination o…

  PublisherOA PDFDOI

Frequent coauthors

• Samuela Pasquali

  Université Paris Cité

  120 shared

• Philippe Derreumaux

  Institut Universitaire de France

  120 shared

• Aatto Laaksonen

  113 shared

• Catherine Etchebest

  Inserm

  86 shared

• Carolina Corrêa Giron

  Universidade de São Paulo

  60 shared

• Sergio Alejandro Poveda Cuevas

  Goethe University Frankfurt

  46 shared

• Fabio Sterpone

  Centre National de la Recherche Scientifique

  35 shared

• Bo Jönsson

  Lund University

  13 shared

Education

• Docent (Livre-docente), Biomolecular Sciences - School of Pharmaceutical Sciences at Ribeirão Preto

  Universidade de São Paulo

  2008

• Ph.D. in Theoretical Chemistry, Theoretical Chemistry

  Lunds Universitet

  2000

Similar researchers at North Carolina State University

• Sung Woo Kimh-89
• Jack Odleh-51
• Matt Pooreh-28