Huiman Xie Barnhart
· James B. Duke Distinguished Professor of Biostatistics & BioinformaticsDuke University · Biostatistics and Bioinformatics
Active 1993–2026
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About
Huiman Xie Barnhart is the James B. Duke Distinguished Professor of Biostatistics & Bioinformatics at Duke University. He also serves as a Professor of Biostatistics & Bioinformatics, the Associate Chair for Faculty Mentorship and Development, and is a member of the Duke Clinical Research Institute. His academic and professional roles are based at Duke's Department of Biostatistics and Bioinformatics, located at 2424 Erwin Road, Durham, NC. His research focuses on biostatistics and bioinformatics, contributing to the advancement of these fields through his leadership and scholarly work.
Research topics
- Medicine
- Chemistry
- Internal medicine
- Traditional medicine
- Intensive care medicine
- Food science
- Gastroenterology
Selected publications
A revised electronic version of RUCAM for the diagnosis of DILI
Hepatology · 2022 · 114 citations
Background and Aims: Roussel Uclaf Causality Assessment Method (RUCAM) for DILI has been hindered by subjectivity and poor reliability. We sought to improve the RUCAM using data from the Drug-Induced Liver Injury Network (DILIN) and the Spanish DILI Registry, published literature, and it- erative computer modeling. Approach and Results: RUCAM criteria were updated, clarified, and com- puterized. We removed criteria 3 (risk factors) for lack of added value and cri- teria 4 because we felt it more…
HLA‐B*35:01 and Green Tea–Induced Liver Injury
Hepatology · 2020 · 92 citations
Background and Aims Herbal supplements, and particularly multi‐ingredient products, have become increasingly common causes of acute liver injury. Green tea is a frequent component in implicated products, but its role in liver injury is controversial. The aim of this study was to better characterize the clinical features, outcomes, and pathogenesis of green tea‐associated liver injury. Approach and Results Among 1,414 patients enrolled in the U.S. Drug‐Induced Liver Injury Network who underwent f…
Incidence of Idiosyncratic Drug-Induced Liver Injury Caused by Prescription Drugs
Drug Safety · 2024-09-24 · 9 citations
articleOpen accessRefinement of Hy Law Using the Drug-Induced Liver Injury Network Database
The American Journal of Gastroenterology · 2024-10-18 · 7 citations
articleOpen accessINTRODUCTION: Hyman Zimmerman observed that hepatocellular (HC) drug-induced liver injury (DILI) with jaundice had a mortality rate of ≥ 10% (Hy Law). Hy Law does not specify the timing of liver tests nor the definition of HC DILI versus cholestatic or mixed (C/M) DILI. We aimed to assess the validity of Hy Law in the prospective DILI Network (DILIN) cohort. METHODS: Drugs with ≥10 confirmed DILI cases with jaundice were analyzed. Four permutations of Hy Law were applied: R ≥ 5 using initial (1)…
The American Journal of Gastroenterology · 2025-04-10 · 6 citations
articleOpen accessINTRODUCTION: Fluoroquinolones (FQ) have a favorable safety profile, but the risk of drug-induced liver injury (DILI) is well described. The aim of this study was to identify clinical features and HLA genetic variants associated with FQ-DILI in a large national registry. METHODS: Analysis of FQ-DILI cases enrolled in DILI Network between 2004 and 2022. HLA class I and II alleles were sequenced by the Illumina MiSeq platform. RESULTS: Sixty-one cases (32 ciprofloxacin, 22 levofloxacin, 7 moxiflox…
Recent grants
NIH · $485k · 2012
Drug Induced Liver Injury Network Data Coordinating Center
NIH · $23.8M · 2003–2028
NIH · $541k · 2003
Frequent coauthors
- 335 shared
Evan R. Myers
Duke University
- 314 shared
Nicholas A. Cataldo
- 311 shared
Peter G. McGovern
- 310 shared
Sandra Ann Carson
Yale University
- 309 shared
William D. Schlaff
Thomas Jefferson University
- 308 shared
Michael P. Steinkampf
- 308 shared
Michael P. Diamond
- 308 shared
John E. Nestler
European Gravitational Observatory
Education
- 1992
PhD, Statistics
University of Pittsburgh
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