Allison Elizabeth Ashley-Koch

About

Allison Elizabeth Ashley-Koch is a Professor in Medicine, Molecular Genetics and Microbiology, and Biostatistics and Bioinformatics at Duke University. She is a faculty member of the Duke Institute for Brain Sciences and the Duke Molecular Physiology Institute. Her research focuses on biostatistics, bioinformatics, and genetics, contributing to the understanding of complex biological systems and diseases. She is associated with the Duke Center for Statistical Genetics and Genomics, engaging in research that advances the fields of genomics and biomedical informatics.

Selected publications

• Genetic diversity fuels gene discovery for tobacco and alcohol use

  Nature · 2022 · 504 citations

  . Here we leveraged global genetic diversity across 3.4 million individuals from four major clines of global ancestry (approximately 21% non-European) to power the discovery and fine-mapping of genomic loci associated with tobacco and alcohol use, to inform function of these loci via ancestry-aware transcriptome-wide association studies, and to evaluate the genetic architecture and predictive power of polygenic risk within and across populations. We found that increases in sample size and geneti…

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• Polygenic and developmental profiles of autism differ by age at diagnosis

  Nature · 2025-10-01 · 24 citations

  articleOpen access

  Abstract Although autism has historically been conceptualized as a condition that emerges in early childhood 1,2 , many autistic people are diagnosed later in life 3–5 . It is unknown whether earlier- and later-diagnosed autism have different developmental trajectories and genetic profiles. Using longitudinal data from four independent birth cohorts, we demonstrate that two different socioemotional and behavioural trajectories are associated with age at diagnosis. In independent cohorts of autis…

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• Accelerated Epigenetic Aging and Prospective Morbidity and Mortality Among U.S. Veterans

  The Journals of Gerontology Series A · 2025-04-22 · 9 citations

  articleOpen access

  BACKGROUND: Epigenetic aging measures have promise as surrogate health outcomes in randomized control trials and observational cohort studies. The value of these measures, however, will reflect the extent to which they are associated with prospective health outcomes in real-world medical settings. METHODS: Using data from 2 216 post-9/11 veterans from the VISN 6 MIRECC's Post-Deployment Mental Health Study, we examined whether accelerated epigenetic aging, assessed by DunedinPACE, was associated…

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• A statistical framework for multi-trait rare variant analysis in large-scale whole-genome sequencing studies

  Nature Computational Science · 2025-02-07 · 9 citations

  articleOpen access
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• Sickle cell disease is associated with early-onset clonal hematopoiesis involving DNA damage response pathway mutations

  Blood · 2025-11-03 · 4 citations

  articleOpen access

  Abstract Background: Individuals with sickle cell disease (SCD) face an elevated risk of myeloid leukemias. Recently, myelodysplastic syndrome and acute myeloid leukemia have emerged as complications of curative SCD therapies, including gene therapy and allogeneic hematopoietic cell transplantation (HCT). Leukemias arising in SCD have been reported to harbor somatic TP53 mutations, and post-HCT TP53-mutant leukemias have been traced to low-level TP53 clones detectable pre-HCT. These findings sug…

  PublisherOA PDFDOI

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