Cynthia Jan Coffman
· Professor of Biostatistics & BioinformaticsDuke University · Biostatistics and Bioinformatics
Active 1983–2026
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About
Professor Cynthia Jan Coffman is associated with the Duke Center for Combinatorial Gene Regulation, which is an NIH Center of Excellence in Genomic Science. The center aims to make combinatorial studies of the function of regulatory elements and noncoding variants routine. Its goal is to develop the first systematic and comprehensive framework for determining the effects of combinations of regulatory elements on gene expression and downstream phenotypes. This work is expected to transform human disease studies by prioritizing thousands of genes for targeted study and drug design, and to advance the prediction of the pathogenicity of noncoding variants that have not been observed, which is crucial for whole genome sequencing studies of both rare and common diseases.
Research topics
- Medicine
- Psychology
- Internal medicine
- Political Science
- Computer Science
- Environmental health
- Clinical psychology
- Intensive care medicine
- Law
- Endocrinology
Selected publications
JAMA · 2021 · 131 citations
This JAMA Guide to Statistics and Methods describes how intention-to-treat, per-protocol, and as-treated approaches to analysis differ with regard to the patient population and treatment assignments and their implications for interpretation of treatment effects in clinical trials.
Stepped Exercise Program for Patients With Knee Osteoarthritis
Annals of Internal Medicine · 2020 · 86 citations
Senior authorCorrespondingBACKGROUND: Evidence-based models are needed to deliver exercise-related services for knee osteoarthritis efficiently and according to patient needs OBJECTIVE: To examine a stepped exercise program for patients with knee osteoarthritis (STEP-KOA). DESIGN: Randomized controlled trial. (ClinicalTrials.gov: NCT02653768). SETTING: 2 U.S. Department of Veterans Affairs sites. PARTICIPANTS: 345 patients (mean age, 60 years; 15% female; 67% people of color) with symptomatic knee osteoarthritis. INTERVE…
The Science of Diabetes Self-Management and Care · 2021 · 9 citations
PURPOSE: The purpose of this project was to identify additional facets of diabetes distress (DD) in veterans that may be present due to the veteran's military-related experience. METHODS: The study team completed cognitive interviews with veterans with type 2 diabetes mellitus (T2DM) to examine how they answered the Diabetes Distress Scale (DD Scale), a tool that assesses DD. The DD Scale was used because of its strong associations with self-management challenges, physician-related distress, and…
Osteoarthritis and Cartilage Open · 2025-01-23 · 5 citations
articleOpen accessObjective: Variability exists in the degree of improvement patients experience following exercise-based interventions (EBIs) for knee osteoarthritis (KOA), but understanding of this heterogeneity is limited. Using a machine learning approach, this study leveraged data from two randomized controlled trials (RCTs) to identify patient characteristics contributing to differential treatment effects. Design: The RCTs enrolled n = 621 patients and evaluated three EBIs (group-based physical therapy (P…
Health Services Research · 2024-08-13 · 5 citations
articleOpen accessOBJECTIVE: To assess the effects of an evidence-based family caregiver training program (implementation of Helping Invested Families Improve Veteran Experiences Study [iHI-FIVES]) in the Veterans Affairs healthcare system on Veteran days not at home and family caregiver well-being. DATA SOURCES AND STUDY SETTING: Participants included Veterans referred to home- and community-based services with an identified caregiver across 8 medical centers and confirmed family caregivers of eligible Veterans.…
Frequent coauthors
- 320 shared
Kelli D. Allen
- 219 shared
Eugene Ž. Oddone
Durham VA Health Care System
- 203 shared
Hayden B. Bosworth
- 203 shared
Susan N. Hastings
Durham VA Health Care System
- 188 shared
William S. Yancy
Duke University
- 161 shared
Corrine I. Voils
William S. Middleton Memorial Veterans Hospital
- 157 shared
Courtney H. Van Houtven
Duke University
- 147 shared
David Edelman
Duke University
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