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George L Anesi

George L Anesi

· MD MSCE FCCM ATSF

University of Pennsylvania · Rehabilitation Medicine

Active 2010–2026

h-index25
Citations2.0k
Papers9672 last 5y
Funding$837k1 active

Academic metrics are sourced from OpenAlex and public funding records; values may differ from Google Scholar.

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About

George L Anesi, MD, MSCE, FCCM, ATSF, is an Assistant Professor of Medicine in the Division of Pulmonary, Allergy, and Critical Care at the Hospital of the University of Pennsylvania. His clinical expertise includes critical care, sepsis, acute respiratory failure, influenza, COVID-19, respiratory viruses, and emerging/high-consequence pathogens. He also has expertise in hospital operations, preparedness and response, hospital capacity strain, global health, and clinical epidemiology. His research focuses on hospital preparedness and the evaluation of critical care and acute care resources during times of system strain, including situations of dynamic strain such as demand variation, seasonal trends, epidemics, and disasters, as well as fixed strain in resource-limited settings domestically and globally.

Research topics

  • Medicine
  • Internal medicine
  • Virology
  • Gastroenterology
  • Emergency medicine
  • Cardiology
  • Demography

Selected publications

  • COVID-19 and cardiac arrhythmias

    Heart Rhythm · 2020 · 417 citations

    DOI

  • Locally Informed Simulation to Predict Hospital Capacity Needs During the COVID-19 Pandemic

    Annals of Internal Medicine · 2020-04-07 · 319 citations

    article

    BACKGROUND: The coronavirus disease 2019 (COVID-19) pandemic challenges hospital leaders to make time-sensitive, critical decisions about clinical operations and resource allocations. OBJECTIVE: To estimate the timing of surges in clinical demand and the best- and worst-case scenarios of local COVID-19-induced strain on hospital capacity, and thus inform clinical operations and staffing demands and identify when hospital capacity would be saturated. DESIGN: Monte Carlo simulation instantiation o…

    PublisherDOI

  • Characteristics, Outcomes, and Trends of Patients With COVID-19–Related Critical Illness at a Learning Health System in the United States

    Annals of Internal Medicine · 2021-01-18 · 122 citations

    articleOpen access1st author

    BACKGROUND: The coronavirus disease 2019 (COVID-19) pandemic continues to surge in the United States and globally. OBJECTIVE: To describe the epidemiology of COVID-19-related critical illness, including trends in outcomes and care delivery. DESIGN: Single-health system, multihospital retrospective cohort study. SETTING: 5 hospitals within the University of Pennsylvania Health System. PATIENTS: Adults with COVID-19-related critical illness who were admitted to an intensive care unit (ICU) with ac…

    PublisherOA PDFDOI

  • A Multicenter Evaluation of the Seraph 100 Microbind Affinity Blood Filter for the Treatment of Severe COVID-19

    Critical Care Explorations · 2022 · 38 citations

    The Seraph100 Microbind Affinity Blood Filter (Seraph 100) (ExThera Medical, Martinez, CA) is an extracorporeal therapy that can remove pathogens from blood, including severe acute respiratory syndrome coronavirus 2. The aim of this study was to evaluate safety and efficacy of Seraph 100 treatment for COVID-19. DESIGN: Retrospective cohort study. SETTING: Nine participating ICUs. PATIENTS: = 53). INTERVENTION: Treatment with Seraph 100. MEASUREMENTS AND MAIN RESULTS: = 0.001), a difference that…

    DOI

  • Impact of COVID-19 on inpatient clinical emergencies: A single-center experience

    Resuscitation Plus · 2021 · 8 citations

    AIM: Determine changes in rapid response team (RRT) activations and describe institutional adaptations made during a surge in hospitalizations for coronavirus disease 2019 (COVID-19). METHODS: Using prospectively collected data, we compared characteristics of RRT calls at our academic hospital from March 7 through May 31, 2020 (COVID-19 era) versus those from January 1 through March 6, 2020 (pre-COVID-19 era). We used negative binomial regression to test differences in RRT activation rates norma…

    PublisherDOI

Recent grants

Frequent coauthors

Awards & honors

  • Senior Fellow, Leonard Davis Institute of Health Economics (…
  • Faculty Fellow, Center for Clinical Epidemiology and Biostat…
  • Senior Fellow, Center for Public Health Initiatives (CPHI)

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