Federico Zuckermann

About

Dr. Federico Zuckermann is a Professor of Immunology in the Department of Pathobiology at the College of Veterinary Medicine, University of Illinois. He earned a DVM equivalent degree with honors from the Universidad Nacional Autonoma de Mexico (UNAM) and a PhD in Immunology from the University of Texas Southwestern Medical Center. His research focuses on understanding the innate and adaptive immune responses of swine to viruses, particularly porcine reproductive and respiratory syndrome virus and influenza A virus of swine. He investigates mechanisms used by viral pathogens to evade immune responses and applies this knowledge to develop effective vaccines. Dr. Zuckermann has contributed significantly to the field through his work on porcine macrophage biology and the role of the intestinal microbiome in activating innate immune defenses of swine. He is the inventor of multiple patents related to vaccine technology and has authored over 85 scientific publications. In 2010, he founded Aptimmune Biologics to commercialize vaccine technologies developed in his laboratory, including a novel porcine alveolar macrophage cell line and a PRRS virus vaccine strain. Dr. Zuckermann has served as past-President of the American Association of Veterinary Immunologists and has received over three million dollars in research funding.

Research topics

• Biology
• Virology
• Genetics
• Immunology
• Microbiology
• Internal medicine
• Medicine

Selected publications

• Innate and adaptive immunity against Porcine Reproductive and Respiratory Syndrome Virus

  Veterinary Immunology and Immunopathology · 2015-07-18 · 203 citations

  reviewSenior author
  PublisherDOI

• North American Porcine Reproductive and Respiratory Syndrome Viruses Inhibit Type I Interferon Production by Plasmacytoid Dendritic Cells

  Journal of Virology · 2010-12-30 · 88 citations

  articleOpen accessSenior authorCorresponding

  Although enveloped viruses typically trigger the prodigious secretion of alpha interferon (IFN-α) by plasmacytoid dendritic cells (pDC), porcine pDC remain quiescent when exposed to porcine reproductive and respiratory syndrome virus (PRRSV). This inactivity is likely due to virus-mediated interference since the typical IFN-α response by either purified or nonsorted porcine pDC to transmissible gastroenteritis virus (TGEV) or the Toll-like receptor 9 agonist, oligodeoxynucleotide (ODN) D19, was…

  PublisherOA PDFDOI

• Identification of immunodominant T-cell epitopes present in glycoprotein 5 of the North American genotype of porcine reproductive and respiratory syndrome virus

  Vaccine · 2008-07-01 · 73 citations

  articleSenior authorCorresponding
  PublisherDOI

• Development of an 8-plex Luminex assay to detect swine cytokines for vaccine development: Assessment of immunity after porcine reproductive and respiratory syndrome virus (PRRSV) vaccination

  Vaccine · 2010-05-19 · 62 citations

  article
  PublisherDOI

• Lactobacillus rhamnosus HN001 Attenuates Allergy Development in a Pig Model

  PLoS ONE · 2011-02-28 · 59 citations

  articleOpen accessSenior author

  BACKGROUND: Probiotics have been studied as immunomodulatory agents of allergy. Several human probiotic trials tracking the development of eczema and other forms of allergy have yielded inconsistent results. A recent infant study demonstrated that pre and postnatal Lactobacillus rhamnosus HN001 (HN001) supplementation decreased the prevalence of eczema and IgE associated eczema. However, the influence of HN001 on the incidence of wheeze, asthma, and/or other allergic manifestations has yet to be…

  PublisherOA PDFDOI

Frequent coauthors

• Robert J. Husmann

  University of Illinois Urbana-Champaign

  43 shared

• Ronald M. Weigel

  29 shared

• Lawrence D. Firkins

  29 shared

• William M. Schnitzlein

  27 shared

• Richard E. Isaacson

  Cornell University

  26 shared

• Joseph A. DiPietro

  University of Southern Indiana

  25 shared

• Joan K. Lunney

  Agricultural Research Service

  24 shared

• Armin Saalmüller

  University of Veterinary Medicine Vienna

  19 shared

Labs

• Histology LaboratoryPI

  The Comparative Biosciences Histology Laboratory is a departmental laboratory that provides histologic technical services and support for teaching and research projects.

Education

• PhD, Graduate Program in Immunology

  The University of Texas Southwestern Medical Center Medical School

  1986

• DVM, College of Veterinary Medicine

  Universidad Nacional Autónoma de México Instituto de Biología

  1979

Awards & honors

• Past-President of the American Association of Veterinary Imm…
• Inventor of nine patents

Similar researchers at University of Illinois Urbana-Champaign

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• Weiping Zhangh-50