David Kimelman
· Professor EmeritusVerifiedUniversity of Washington · Biology
Active 1976–2024
Research topics
- Evolutionary biology
- Genetics
- Cell biology
- Biology
Selected publications
A single-cell time-lapse of mouse prenatal development from gastrula to birth
Nature · 2024 · 165 citations
- Biology
- Genetics
- Evolutionary biology
from earlier timepoints, to construct a rooted tree of cell-type relationships that spans the entirety of prenatal development, from zygote to birth. Throughout this tree, we systematically nominate genes encoding transcription factors and other proteins as candidate drivers of the in vivo differentiation of hundreds of cell types. Remarkably, the most marked temporal shifts in cell states are observed within one hour of birth and presumably underlie the massive physiological adaptations that must accompany the successful transition of a mammalian fetus to life outside the womb.
Recent grants
Regulation of Zebrafish Germ Layer Patterning
NSF · $360k · 2003–2008
NIH · $2.4M · 2006
Maternal Regulation of Zebrafish Germ Layer Patterning
NSF · $320k · 2000–2003
NIH · $4.0M · 2008–2021
NIH · $4.4M · 2011
Frequent coauthors
- 19 shared
Jay Shendure
Howard Hughes Medical Institute
- 16 shared
Randall T. Moon
- 13 shared
Benjamin L. Martin
Stony Brook University
- 12 shared
Brian A. Rowning
Lawrence Berkeley National Laboratory
- 12 shared
Cole Trapnell
Brotman Baty Institute
- 12 shared
Cynthia Yost
Fred Hutch Cancer Center
- 12 shared
Carolyn A. Larabell
University of California, San Francisco
- 11 shared
Wenqing Xu
State Key Laboratory of Synthetic Chemistry
Education
- 1985
PhD, Biochemistry and Molecular Biology
Harvard University
- 1979
BS, Chemistry
Stanford University
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