Anna Wald
University of Washington · Epidemiology
Active 1965–2025
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About
Anna Wald is a Professor in the Department of Epidemiology at the University of Washington, with additional appointments in Medicine - Allergy and Infectious Diseases, and Laboratory Medicine and Pathology. Her research centers on the epidemiology and natural history of chronic viral infections in both immunocompetent and immunocompromised hosts. She is actively involved in clinical trials of antiviral therapeutics and prophylactic and therapeutic vaccines for viral pathogens. Her ongoing studies also address the interaction between sexually transmitted infections and the microbiome. Dr. Wald's work contributes to understanding viral infections and developing interventions to prevent and treat these diseases.
Research topics
- Medicine
- Immunology
- Environmental health
- Internal medicine
- Biology
- Genetics
- Obstetrics
- Gynecology
- Virology
- Computational biology
Selected publications
Rapid decline in vaccine-boosted neutralizing antibodies against SARS-CoV-2 Omicron variant
Cell Reports Medicine · 2022-06-20 · 167 citations
articleOpen accessThe Omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) exhibits reduced susceptibility to vaccine-induced neutralizing antibodies, requiring a boost to generate protective immunity. We assess the magnitude and short-term durability of neutralizing antibodies after homologous and heterologous boosting with mRNA and Ad26.COV2.S vaccines. All prime-boost combinations substantially increase the neutralization titers to Omicron, although the boosted titers decline rapidly…
Annals of Internal Medicine · 2020-12-07 · 93 citations
articleOpen accessBACKGROUND: Effective prevention against coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is currently limited to nonpharmaceutical strategies. Laboratory and observational data suggested that hydroxychloroquine had biological activity against SARS-CoV-2, potentially permitting its use for prevention. OBJECTIVE: To test hydroxychloroquine as postexposure prophylaxis for SARS-CoV-2 infection. DESIGN: Household-randomized, double-blind, c…
Frontiers in Public Health · 2020 · 46 citations
Upon baseline evaluation of a cohort of low risk AGYW, we found high numbers of STIs, especially CT, which is not routinely screened for in Kenyan settings. Interventions to address STIs and unintended pregnancy should target girls pre-sexual debut, including those who do not self-identify as at risk.
Scientific Reports · 2021 · 33 citations
Rapid generation of diagnostics is paramount to understand epidemiology and to control the spread of emerging infectious diseases such as COVID-19. Computational methods to predict serodiagnostic epitopes that are specific for the pathogen could help accelerate the development of new diagnostics. A systematic survey of 27 SARS-CoV-2 proteins was conducted to assess whether existing B-cell epitope prediction methods, combined with comprehensive mining of sequence databases and structural data, co…
Nature Immunology · 2023-12-06 · 31 citations
articleOpen access
Recent grants
NIH · $64.0M · 2019
NIH · $5.1M · 2016
NIH · $29.9M · 2020
Frequent coauthors
- 978 shared
Lawrence Corey
Fred Hutch Cancer Center
- 507 shared
Amalia Magaret
University of Washington
- 412 shared
David M. Koelle
University of Washington
- 392 shared
Christine Johnston
Fred Hutch Cancer Center
- 278 shared
Stacy Selke
University of Washington
- 241 shared
Meei‐Li Huang
- 196 shared
Keith R. Jerome
University of Washington
- 190 shared
Corey Casper
Fred Hutch Cancer Center
Labs
Department of EpidemiologyPI
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