D.S. Fahmeed Hyder

About

D.S. Fahmeed Hyder is a Professor of Biomedical Engineering at Yale University, with additional appointments in Radiology & Biomedical Imaging. His research focuses on developing quantitative and translational imaging technologies, primarily based on magnetic resonance methods, to visualize molecular processes of function and dysfunction at the laminar level. A primary interest in his laboratory is to develop functional imaging techniques that relate neural activity to underlying laminar structure in health and disease. He is also actively involved in molecular imaging with magnetic resonance technologies, connecting disciplines from chemistry and physics to material science and physiology. Hyder's work addresses the societal burden of misdiagnosed brain disorders and diseases by leading breakthroughs in imaging technologies that enhance understanding of brain function and pathology.

Research topics

• Medicine
• Artificial Intelligence
• Computer Science
• Chemistry
• Biology
• Machine Learning
• Neuroscience
• Internal medicine
• Nuclear magnetic resonance
• Materials science

Selected publications

• Simultaneous cortex-wide fluorescence Ca2+ imaging and whole-brain fMRI

  Nature Methods · 2020 · 179 citations

  DOI

• Manganese Ferrite Nanoparticles (MnFe2O4): Size Dependence for Hyperthermia and Negative/Positive Contrast Enhancement in MRI

  Nanomaterials · 2020 · 161 citations

  nanoparticles in MRI and hyperthermia studies for biomedical research.

  DOI

• A consensus protocol for functional connectivity analysis in the rat brain

  Nature Neuroscience · 2023 · 123 citations

  Task-free functional connectivity in animal models provides an experimental framework to examine connectivity phenomena under controlled conditions and allows for comparisons with data modalities collected under invasive or terminal procedures. Currently, animal acquisitions are performed with varying protocols and analyses that hamper result comparison and integration. Here we introduce StandardRat, a consensus rat functional magnetic resonance imaging acquisition protocol tested across 20 cent…

  DOI

• Renal plasticity revealed through reversal of polycystic kidney disease in mice

  Nature Genetics · 2021 · 118 citations

  DOI

• Cysteine depletion triggers adipose tissue thermogenesis and weight loss

  Nature Metabolism · 2025-06-03 · 33 citations

  articleOpen access
  PublisherOA PDFDOI

Recent grants

• Development of Ultra-High Resolution in Vivo NMR Methods for Functional Molecular Physiology Studies in Mouse Brain

  NSF · $475k · 2001–2005

• NIH Grant R01DC003710

  NIH · $2.7M · 2008

• Assessing the Relationship between Cortical Oxidative Metabolism and Working Memory Deficits Under NMDA Receptor Blockade

  NIH · $404k · 2017–2019

Frequent coauthors

• Douglas L. Rothman

  Resonance Research (United States)

  263 shared

• Péter Hermán

  Yale University

  221 shared

• Basavaraju G. Sanganahalli

  Yale University

  187 shared

• Daniel Coman

  Yale University

  173 shared

• Hal Blumenfeld

  Yale University

  119 shared

• Robert G. Shulman

  Yale University

  83 shared

• Kevin L. Behar

  Yale University

  83 shared

• Ikuhiro Kida

  57 shared

Education

• Ph.D., Chemistry

  Yale University

  1995

Awards & honors

• Pilot Award, Yale-UCL Medical Technologies Collaborative: Im…
• Pilot Award, Juvenile Diabetes Research Foundation (2008)
• Niels Lassen Award, International Society for Cerebral Blood…
• 21st Century Science Initiative Grant: James S. McDonnell Fo…
• Melvin H. Knisely Award, International Society on Oxygen Tra…

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